Locus specific epigenetic modalities of random allelic expression imbalance

Some autosomal genes are expressed in a random monoallelic manner, but its extent and mechanisms have remained unclear. Here the authors show robust monoallelic expression in cell lines and mice, where the silent allele can be reexpressed using epidrugs. Further, they find these genes display variou...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lucile Marion-Poll, Benjamin Forêt, Dina Zielinski, Florian Massip, Mikael Attia, Ava C. Carter, Laurène Syx, Howard Y. Chang, Anne-Valerie Gendrel, Edith Heard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b793b4a1019a4a6fa1acd10a7e4751c8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b793b4a1019a4a6fa1acd10a7e4751c8
record_format	dspace
spelling	oai:doaj.org-article:b793b4a1019a4a6fa1acd10a7e4751c82021-12-02T14:54:28ZLocus specific epigenetic modalities of random allelic expression imbalance10.1038/s41467-021-25630-32041-1723https://doaj.org/article/b793b4a1019a4a6fa1acd10a7e4751c82021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25630-3https://doaj.org/toc/2041-1723Some autosomal genes are expressed in a random monoallelic manner, but its extent and mechanisms have remained unclear. Here the authors show robust monoallelic expression in cell lines and mice, where the silent allele can be reexpressed using epidrugs. Further, they find these genes display various modalities of allelic expression with different degrees of allelic imbalance.Lucile Marion-PollBenjamin ForêtDina ZielinskiFlorian MassipMikael AttiaAva C. CarterLaurène SyxHoward Y. ChangAnne-Valerie GendrelEdith HeardNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucile Marion-Poll Benjamin Forêt Dina Zielinski Florian Massip Mikael Attia Ava C. Carter Laurène Syx Howard Y. Chang Anne-Valerie Gendrel Edith Heard Locus specific epigenetic modalities of random allelic expression imbalance
description	Some autosomal genes are expressed in a random monoallelic manner, but its extent and mechanisms have remained unclear. Here the authors show robust monoallelic expression in cell lines and mice, where the silent allele can be reexpressed using epidrugs. Further, they find these genes display various modalities of allelic expression with different degrees of allelic imbalance.
format	article
author	Lucile Marion-Poll Benjamin Forêt Dina Zielinski Florian Massip Mikael Attia Ava C. Carter Laurène Syx Howard Y. Chang Anne-Valerie Gendrel Edith Heard
author_facet	Lucile Marion-Poll Benjamin Forêt Dina Zielinski Florian Massip Mikael Attia Ava C. Carter Laurène Syx Howard Y. Chang Anne-Valerie Gendrel Edith Heard
author_sort	Lucile Marion-Poll
title	Locus specific epigenetic modalities of random allelic expression imbalance
title_short	Locus specific epigenetic modalities of random allelic expression imbalance
title_full	Locus specific epigenetic modalities of random allelic expression imbalance
title_fullStr	Locus specific epigenetic modalities of random allelic expression imbalance
title_full_unstemmed	Locus specific epigenetic modalities of random allelic expression imbalance
title_sort	locus specific epigenetic modalities of random allelic expression imbalance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b793b4a1019a4a6fa1acd10a7e4751c8
work_keys_str_mv	AT lucilemarionpoll locusspecificepigeneticmodalitiesofrandomallelicexpressionimbalance AT benjaminforet locusspecificepigeneticmodalitiesofrandomallelicexpressionimbalance AT dinazielinski locusspecificepigeneticmodalitiesofrandomallelicexpressionimbalance AT florianmassip locusspecificepigeneticmodalitiesofrandomallelicexpressionimbalance AT mikaelattia locusspecificepigeneticmodalitiesofrandomallelicexpressionimbalance AT avaccarter locusspecificepigeneticmodalitiesofrandomallelicexpressionimbalance AT laurenesyx locusspecificepigeneticmodalitiesofrandomallelicexpressionimbalance AT howardychang locusspecificepigeneticmodalitiesofrandomallelicexpressionimbalance AT annevaleriegendrel locusspecificepigeneticmodalitiesofrandomallelicexpressionimbalance AT edithheard locusspecificepigeneticmodalitiesofrandomallelicexpressionimbalance
_version_	1718389407354978304

Locus specific epigenetic modalities of random allelic expression imbalance

Ejemplares similares