The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice

Yingjuan Xu,1 Zeman Fang,1 Cairu Wu,1 Haiyun Xu,1,2 Jiming Kong,3 Qingjun Huang,1 Handi Zhang1 1Shantou University Mental Health Center, Shantou, Guangdong, People’s Republic of China; 2Affiliated Kangning Hospital, School of Psychiatry, Wenzhou Medical University, Wenzhou, Zhejiang, Peopl...

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Autores principales:	Xu Y, Fang Z, Wu C, Xu H, Kong J, Huang Q, Zhang H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	social defeat stress adolescence myelin oligodendrocyte lineage cells interleulin-1β Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b795f86abc5447ffa37effbfd5080193
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spelling	oai:doaj.org-article:b795f86abc5447ffa37effbfd50801932021-12-02T12:08:48ZThe Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice1178-2021https://doaj.org/article/b795f86abc5447ffa37effbfd50801932020-05-01T00:00:00Zhttps://www.dovepress.com/the-long-term-effects-of-adolescent-social-defeat-stress-on-oligodendr-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yingjuan Xu,1 Zeman Fang,1 Cairu Wu,1 Haiyun Xu,1,2 Jiming Kong,3 Qingjun Huang,1 Handi Zhang1 1Shantou University Mental Health Center, Shantou, Guangdong, People’s Republic of China; 2Affiliated Kangning Hospital, School of Psychiatry, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, CanadaCorrespondence: Handi ZhangShantou University Mental Health Center, Shantou, Guangdong 515065, People’s Republic of ChinaTel +86-754-82902014Fax +86-754-82510525Email zhanghandi78@163.comObjective: Adverse childhood and adolescent experiences are associated with the emergences of psychopathology later in life and have negative consequences on white matter integrity. However, this adversity-induced white matter impairment remains not fully investigated.Methods: Adolescent Balb/c mice were subjected to intermittent social defeat stress once a day during postnatal days 25 to 40. Then, the subjects were allowed to recover for three weeks before sacrifice. At the end, oligodendrocyte (OL) lineage cells, cell proliferation, and microglia activation, as well as myelin basic protein (MBP) levels in frontal cortex and hippocampus were evaluated. The levels of interleukin (IL)-1β and IL-6 in the brain regions were assessed.Results: MBP protein level in frontal cortex, but not in the hippocampus of defeated mice, decreased significantly compared to controls. The numeral densities of mature OLs, oligodendrocyte progenitor cells, and proliferating cells in medial prefrontal cortex were comparable between the defeated mice and controls. The defeated mice, however, showed significantly higher IL-1β level, although IL-6 level and numeral density of microglia in frontal cortex did not change relative to controls.Conclusion: These results indicate that effects of intermittent social defeat stress on the white matter integrity and OL lineage cells in mouse brain are region- and developmental stage-specific. Upregulated IL-1β may contribute to this negative consequence though the underlying mechanism remains to be investigated.Keywords: social defeat stress, adolescence, myelin, oligodendrocyte lineage cells, interleukin-1βXu YFang ZWu CXu HKong JHuang QZhang HDove Medical Pressarticlesocial defeat stressadolescencemyelinoligodendrocyte lineage cellsinterleulin-1βNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1321-1330 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	social defeat stress adolescence myelin oligodendrocyte lineage cells interleulin-1β Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	social defeat stress adolescence myelin oligodendrocyte lineage cells interleulin-1β Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xu Y Fang Z Wu C Xu H Kong J Huang Q Zhang H The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice
description	Yingjuan Xu,1 Zeman Fang,1 Cairu Wu,1 Haiyun Xu,1,2 Jiming Kong,3 Qingjun Huang,1 Handi Zhang1 1Shantou University Mental Health Center, Shantou, Guangdong, People’s Republic of China; 2Affiliated Kangning Hospital, School of Psychiatry, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, CanadaCorrespondence: Handi ZhangShantou University Mental Health Center, Shantou, Guangdong 515065, People’s Republic of ChinaTel +86-754-82902014Fax +86-754-82510525Email zhanghandi78@163.comObjective: Adverse childhood and adolescent experiences are associated with the emergences of psychopathology later in life and have negative consequences on white matter integrity. However, this adversity-induced white matter impairment remains not fully investigated.Methods: Adolescent Balb/c mice were subjected to intermittent social defeat stress once a day during postnatal days 25 to 40. Then, the subjects were allowed to recover for three weeks before sacrifice. At the end, oligodendrocyte (OL) lineage cells, cell proliferation, and microglia activation, as well as myelin basic protein (MBP) levels in frontal cortex and hippocampus were evaluated. The levels of interleukin (IL)-1β and IL-6 in the brain regions were assessed.Results: MBP protein level in frontal cortex, but not in the hippocampus of defeated mice, decreased significantly compared to controls. The numeral densities of mature OLs, oligodendrocyte progenitor cells, and proliferating cells in medial prefrontal cortex were comparable between the defeated mice and controls. The defeated mice, however, showed significantly higher IL-1β level, although IL-6 level and numeral density of microglia in frontal cortex did not change relative to controls.Conclusion: These results indicate that effects of intermittent social defeat stress on the white matter integrity and OL lineage cells in mouse brain are region- and developmental stage-specific. Upregulated IL-1β may contribute to this negative consequence though the underlying mechanism remains to be investigated.Keywords: social defeat stress, adolescence, myelin, oligodendrocyte lineage cells, interleukin-1β
format	article
author	Xu Y Fang Z Wu C Xu H Kong J Huang Q Zhang H
author_facet	Xu Y Fang Z Wu C Xu H Kong J Huang Q Zhang H
author_sort	Xu Y
title	The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice
title_short	The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice
title_full	The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice
title_fullStr	The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice
title_full_unstemmed	The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice
title_sort	long-term effects of adolescent social defeat stress on oligodendrocyte lineage cells and neuroinflammatory mediators in mice
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b795f86abc5447ffa37effbfd5080193
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The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice

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