Drug repurposing screens identify chemical entities for the development of COVID-19 interventions
Here, the authors perform repurposing screens of the ReFRAME drug library in two cell lines and identify inhibitors of SARS-CoV-2 infection. Antiviral activity of prodrug MK-4482 is confirmed in hamsters.
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Nature Portfolio
2021
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oai:doaj.org-article:b79629899ac84da0ab6e053c69619b492021-12-02T17:51:27ZDrug repurposing screens identify chemical entities for the development of COVID-19 interventions10.1038/s41467-021-23328-02041-1723https://doaj.org/article/b79629899ac84da0ab6e053c69619b492021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23328-0https://doaj.org/toc/2041-1723Here, the authors perform repurposing screens of the ReFRAME drug library in two cell lines and identify inhibitors of SARS-CoV-2 infection. Antiviral activity of prodrug MK-4482 is confirmed in hamsters.Malina A. BakowskiNathan BeutlerKaren C. WolffMelanie G. KirkpatrickEmily ChenTu-Trinh H. NguyenLaura RivaNamir ShaabaniMara ParrenJames RickettsAnil K. GuptaKastin PanPeiting KuoMacKenzie FullerElijah GarciaJohn R. TeijaroLinlin YangDebashis SahooVictor ChiEdward HuangNatalia VargasAmanda J. RobertsSoumita DasPradipta GhoshAshley K. WoodsSean B. JosephMitchell V. HullPeter G. SchultzDennis R. BurtonArnab K. ChatterjeeCase W. McNamaraThomas F. RogersNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Malina A. Bakowski Nathan Beutler Karen C. Wolff Melanie G. Kirkpatrick Emily Chen Tu-Trinh H. Nguyen Laura Riva Namir Shaabani Mara Parren James Ricketts Anil K. Gupta Kastin Pan Peiting Kuo MacKenzie Fuller Elijah Garcia John R. Teijaro Linlin Yang Debashis Sahoo Victor Chi Edward Huang Natalia Vargas Amanda J. Roberts Soumita Das Pradipta Ghosh Ashley K. Woods Sean B. Joseph Mitchell V. Hull Peter G. Schultz Dennis R. Burton Arnab K. Chatterjee Case W. McNamara Thomas F. Rogers Drug repurposing screens identify chemical entities for the development of COVID-19 interventions |
| description |
Here, the authors perform repurposing screens of the ReFRAME drug library in two cell lines and identify inhibitors of SARS-CoV-2 infection. Antiviral activity of prodrug MK-4482 is confirmed in hamsters. |
| format |
article |
| author |
Malina A. Bakowski Nathan Beutler Karen C. Wolff Melanie G. Kirkpatrick Emily Chen Tu-Trinh H. Nguyen Laura Riva Namir Shaabani Mara Parren James Ricketts Anil K. Gupta Kastin Pan Peiting Kuo MacKenzie Fuller Elijah Garcia John R. Teijaro Linlin Yang Debashis Sahoo Victor Chi Edward Huang Natalia Vargas Amanda J. Roberts Soumita Das Pradipta Ghosh Ashley K. Woods Sean B. Joseph Mitchell V. Hull Peter G. Schultz Dennis R. Burton Arnab K. Chatterjee Case W. McNamara Thomas F. Rogers |
| author_facet |
Malina A. Bakowski Nathan Beutler Karen C. Wolff Melanie G. Kirkpatrick Emily Chen Tu-Trinh H. Nguyen Laura Riva Namir Shaabani Mara Parren James Ricketts Anil K. Gupta Kastin Pan Peiting Kuo MacKenzie Fuller Elijah Garcia John R. Teijaro Linlin Yang Debashis Sahoo Victor Chi Edward Huang Natalia Vargas Amanda J. Roberts Soumita Das Pradipta Ghosh Ashley K. Woods Sean B. Joseph Mitchell V. Hull Peter G. Schultz Dennis R. Burton Arnab K. Chatterjee Case W. McNamara Thomas F. Rogers |
| author_sort |
Malina A. Bakowski |
| title |
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions |
| title_short |
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions |
| title_full |
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions |
| title_fullStr |
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions |
| title_full_unstemmed |
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions |
| title_sort |
drug repurposing screens identify chemical entities for the development of covid-19 interventions |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b79629899ac84da0ab6e053c69619b49 |
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