Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line

“Protein relocalisation plays a major role in the innate immune response but remains incompletely characterised. Here, the authors combine temporal proteomics with LOPIT, a spatial proteomic workflow, in a fully Bayesian framework to elucidate spatiotemporal proteomic changes during the LPS-induced...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Claire M. Mulvey, Lisa M. Breckels, Oliver M. Crook, David J. Sanders, Andre L. R. Ribeiro, Aikaterini Geladaki, Andy Christoforou, Nina Kočevar Britovšek, Tracey Hurrell, Michael J. Deery, Laurent Gatto, Andrew M. Smith, Kathryn S. Lilley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7981d765ae3484fb2248a1903f40b99
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b7981d765ae3484fb2248a1903f40b99
record_format	dspace
spelling	oai:doaj.org-article:b7981d765ae3484fb2248a1903f40b992021-12-02T17:37:13ZSpatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line10.1038/s41467-021-26000-92041-1723https://doaj.org/article/b7981d765ae3484fb2248a1903f40b992021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26000-9https://doaj.org/toc/2041-1723“Protein relocalisation plays a major role in the innate immune response but remains incompletely characterised. Here, the authors combine temporal proteomics with LOPIT, a spatial proteomic workflow, in a fully Bayesian framework to elucidate spatiotemporal proteomic changes during the LPS-induced immune response in THP-1 cells.Claire M. MulveyLisa M. BreckelsOliver M. CrookDavid J. SandersAndre L. R. RibeiroAikaterini GeladakiAndy ChristoforouNina Kočevar BritovšekTracey HurrellMichael J. DeeryLaurent GattoAndrew M. SmithKathryn S. LilleyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claire M. Mulvey Lisa M. Breckels Oliver M. Crook David J. Sanders Andre L. R. Ribeiro Aikaterini Geladaki Andy Christoforou Nina Kočevar Britovšek Tracey Hurrell Michael J. Deery Laurent Gatto Andrew M. Smith Kathryn S. Lilley Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line
description	“Protein relocalisation plays a major role in the innate immune response but remains incompletely characterised. Here, the authors combine temporal proteomics with LOPIT, a spatial proteomic workflow, in a fully Bayesian framework to elucidate spatiotemporal proteomic changes during the LPS-induced immune response in THP-1 cells.
format	article
author	Claire M. Mulvey Lisa M. Breckels Oliver M. Crook David J. Sanders Andre L. R. Ribeiro Aikaterini Geladaki Andy Christoforou Nina Kočevar Britovšek Tracey Hurrell Michael J. Deery Laurent Gatto Andrew M. Smith Kathryn S. Lilley
author_facet	Claire M. Mulvey Lisa M. Breckels Oliver M. Crook David J. Sanders Andre L. R. Ribeiro Aikaterini Geladaki Andy Christoforou Nina Kočevar Britovšek Tracey Hurrell Michael J. Deery Laurent Gatto Andrew M. Smith Kathryn S. Lilley
author_sort	Claire M. Mulvey
title	Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line
title_short	Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line
title_full	Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line
title_fullStr	Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line
title_full_unstemmed	Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line
title_sort	spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the thp-1 human leukaemia cell line
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b7981d765ae3484fb2248a1903f40b99
work_keys_str_mv	AT clairemmulvey spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT lisambreckels spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT olivermcrook spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT davidjsanders spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT andrelrribeiro spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT aikaterinigeladaki spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT andychristoforou spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT ninakocevarbritovsek spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT traceyhurrell spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT michaeljdeery spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT laurentgatto spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT andrewmsmith spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline AT kathrynslilley spatiotemporalproteomicprofilingoftheproinflammatoryresponsetolipopolysaccharideinthethp1humanleukaemiacellline
_version_	1718379905312358400

Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line

Ejemplares similares