SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

Mutant SARS-CoV-2 strains such as B.1.1.7 and B.1.351 have been termed variants of concerns (VoC) due to their enhanced virulence. Here the authors show, using K18-hACE2 transgenic mouse models, that these two VoCs are also more pathogenic in mice, and induce immunity and pathology distinct from tho...

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Autores principales:	Peter Radvak, Hyung-Joon Kwon, Martina Kosikova, Uriel Ortega-Rodriguez, Ruoxuan Xiang, Je-Nie Phue, Rong-Fong Shen, James Rozzelle, Neeraj Kapoor, Taylor Rabara, Jeff Fairman, Hang Xie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b798cec113434016bcaf2b4323e29ab0
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spelling	oai:doaj.org-article:b798cec113434016bcaf2b4323e29ab02021-11-14T12:34:34ZSARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains10.1038/s41467-021-26803-w2041-1723https://doaj.org/article/b798cec113434016bcaf2b4323e29ab02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26803-whttps://doaj.org/toc/2041-1723Mutant SARS-CoV-2 strains such as B.1.1.7 and B.1.351 have been termed variants of concerns (VoC) due to their enhanced virulence. Here the authors show, using K18-hACE2 transgenic mouse models, that these two VoCs are also more pathogenic in mice, and induce immunity and pathology distinct from those from the earlier variants.Peter RadvakHyung-Joon KwonMartina KosikovaUriel Ortega-RodriguezRuoxuan XiangJe-Nie PhueRong-Fong ShenJames RozzelleNeeraj KapoorTaylor RabaraJeff FairmanHang XieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter Radvak Hyung-Joon Kwon Martina Kosikova Uriel Ortega-Rodriguez Ruoxuan Xiang Je-Nie Phue Rong-Fong Shen James Rozzelle Neeraj Kapoor Taylor Rabara Jeff Fairman Hang Xie SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains
description	Mutant SARS-CoV-2 strains such as B.1.1.7 and B.1.351 have been termed variants of concerns (VoC) due to their enhanced virulence. Here the authors show, using K18-hACE2 transgenic mouse models, that these two VoCs are also more pathogenic in mice, and induce immunity and pathology distinct from those from the earlier variants.
format	article
author	Peter Radvak Hyung-Joon Kwon Martina Kosikova Uriel Ortega-Rodriguez Ruoxuan Xiang Je-Nie Phue Rong-Fong Shen James Rozzelle Neeraj Kapoor Taylor Rabara Jeff Fairman Hang Xie
author_facet	Peter Radvak Hyung-Joon Kwon Martina Kosikova Uriel Ortega-Rodriguez Ruoxuan Xiang Je-Nie Phue Rong-Fong Shen James Rozzelle Neeraj Kapoor Taylor Rabara Jeff Fairman Hang Xie
author_sort	Peter Radvak
title	SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains
title_short	SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains
title_full	SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains
title_fullStr	SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains
title_full_unstemmed	SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains
title_sort	sars-cov-2 b.1.1.7 (alpha) and b.1.351 (beta) variants induce pathogenic patterns in k18-hace2 transgenic mice distinct from early strains
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b798cec113434016bcaf2b4323e29ab0
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SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

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