SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

Mutant SARS-CoV-2 strains such as B.1.1.7 and B.1.351 have been termed variants of concerns (VoC) due to their enhanced virulence. Here the authors show, using K18-hACE2 transgenic mouse models, that these two VoCs are also more pathogenic in mice, and induce immunity and pathology distinct from tho...

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Autores principales: Peter Radvak, Hyung-Joon Kwon, Martina Kosikova, Uriel Ortega-Rodriguez, Ruoxuan Xiang, Je-Nie Phue, Rong-Fong Shen, James Rozzelle, Neeraj Kapoor, Taylor Rabara, Jeff Fairman, Hang Xie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/b798cec113434016bcaf2b4323e29ab0
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