Texture Analysis of Sequential Images of T2-weighted Imaging and Diffusion-weighted Imaging for Predicting the Efficacy of Chemoradiotherapy in Cervical Squamous Cell Carcinoma

Objective To investigate the correlation of the texture parameters of T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) with the efficacy of chemoradiotherapy in cervical squamous cell carcinoma. Methods Patients with squamous cell carcinoma of the cervix that underwent chemoradioth...

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Autores principales:	SU Baiyan, QI Yafei, GUAN Hui, HE Yonglan, XUE Huadan, JIN Zhengyu
Formato:	article
Lenguaje:	ZH
Publicado:	Editorial Office of Medical Journal of Peking Union Medical College Hospital 2021
Materias:	cervical carcinoma image texture analysis t2-weighted imaging diffusion-weighted imaging chemoradiotherapy Medicine R
Acceso en línea:	https://doaj.org/article/b799204d1a2e4397851060660987de19
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spelling	oai:doaj.org-article:b799204d1a2e4397851060660987de192021-12-01T01:44:13ZTexture Analysis of Sequential Images of T2-weighted Imaging and Diffusion-weighted Imaging for Predicting the Efficacy of Chemoradiotherapy in Cervical Squamous Cell Carcinoma1674-908110.12290/xhyxzz.2021-0380https://doaj.org/article/b799204d1a2e4397851060660987de192021-10-01T00:00:00Zhttps://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2021-0380https://doaj.org/toc/1674-9081Objective To investigate the correlation of the texture parameters of T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) with the efficacy of chemoradiotherapy in cervical squamous cell carcinoma. Methods Patients with squamous cell carcinoma of the cervix that underwent chemoradiotherapy from February 2015 to January 2016 in Peking Union Medical College Hospital were included retrospectively, and were divided into the disease-progressive group and the disease-stable group according to their prognosis. Texture analysis of baseline T2WI and DWI images before chemoradiotherapy was carried out with Texrad software, and the texture parameters of spatial scale filter (SSF) with radius values of 2, 4 and 6 were obtained. The differences of texture parameters between the two groups were compared, and the correlation between the texture parameters and the curative of chemoradiotherapy in patients with cervical squamous cell carcinoma was analyzed by multivariate Cox regression. Receiver operating characteristic (ROC) curve was used to analyze the performance of texture parameters in predicting disease progression after chemoradiotherapy in patients with cervical squamous cell carcinoma. Results A total of 121 patients with squamous cell carcinoma of the cervix that met the inclusion and exclusion criteria were enrolled in this study. There were 46 cases in the disease-progressive group and 75 cases in the disease-stable group. In T2WI sequential images, there were significant differences in the texture parameters of means (SSF2, SSF4, SSF6), skewness (SSF2, SSF4), and entropy (SSF4, SSF6) between disease-progressive group and disease-stable group (all P < 0.05). In DWI sequential images, there were significant differences in the texture parameters of means (SSF2, SSF4, SSF6), skewness (SSF4, SSF6), and kurtosis (SSF2, SSF4) between the two groups (all P < 0.05). Multivariate Cox regression analysis showed that the texture parameter of means (SSF2, SSF4, SSF6) of T2WI and the texture parameters of means (SSF2, SSF6), entropy (SSF2, SSF4, SSF6) and skewness (SSF4, SSF6) of DWI were correlated with the efficacy of chemoradiotherapy in patients with cervical squamous cell carcinoma (P < 0.05). The Results of ROC analysis showed that the texture parameter of means (T2WI-SSF2, T2WI-SSF4, T2WI-SSF6, DWI-SSF2, DWI-SSF6) and skewness (DWI-SSF6) could predict the progression of cervical squamous cell carcinoma after chemoradiotherapy in patients with cervical squamous cell carcinoma. The area under the curve (AUC) was 0.625-0.746. Among them, the mean of T2WI-SSF4 was the most effective (AUC: 0.746), followed by the mean of T2WI-SSF2 (AUC: 0.725) and the mean of T2WI-SSF6 (AUC: 0.703). Conclusions The texture parameters of baseline T2WI and DWI sequences were correlated with the curative effect of chemoradiotherapy in patients with cervical squamous cell carcinoma. The parameters of means and skewness can predict the progression of cervical squamous carcinoma after chemoradiotherapy, and the mean has a higher predictive power.SU BaiyanQI YafeiGUAN HuiHE YonglanXUE HuadanJIN ZhengyuEditorial Office of Medical Journal of Peking Union Medical College Hospitalarticlecervical carcinomaimage texture analysist2-weighted imagingdiffusion-weighted imagingchemoradiotherapyMedicineRZHXiehe Yixue Zazhi, Vol 12, Iss 5, Pp 713-720 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	cervical carcinoma image texture analysis t2-weighted imaging diffusion-weighted imaging chemoradiotherapy Medicine R
spellingShingle	cervical carcinoma image texture analysis t2-weighted imaging diffusion-weighted imaging chemoradiotherapy Medicine R SU Baiyan QI Yafei GUAN Hui HE Yonglan XUE Huadan JIN Zhengyu Texture Analysis of Sequential Images of T2-weighted Imaging and Diffusion-weighted Imaging for Predicting the Efficacy of Chemoradiotherapy in Cervical Squamous Cell Carcinoma
description	Objective To investigate the correlation of the texture parameters of T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) with the efficacy of chemoradiotherapy in cervical squamous cell carcinoma. Methods Patients with squamous cell carcinoma of the cervix that underwent chemoradiotherapy from February 2015 to January 2016 in Peking Union Medical College Hospital were included retrospectively, and were divided into the disease-progressive group and the disease-stable group according to their prognosis. Texture analysis of baseline T2WI and DWI images before chemoradiotherapy was carried out with Texrad software, and the texture parameters of spatial scale filter (SSF) with radius values of 2, 4 and 6 were obtained. The differences of texture parameters between the two groups were compared, and the correlation between the texture parameters and the curative of chemoradiotherapy in patients with cervical squamous cell carcinoma was analyzed by multivariate Cox regression. Receiver operating characteristic (ROC) curve was used to analyze the performance of texture parameters in predicting disease progression after chemoradiotherapy in patients with cervical squamous cell carcinoma. Results A total of 121 patients with squamous cell carcinoma of the cervix that met the inclusion and exclusion criteria were enrolled in this study. There were 46 cases in the disease-progressive group and 75 cases in the disease-stable group. In T2WI sequential images, there were significant differences in the texture parameters of means (SSF2, SSF4, SSF6), skewness (SSF2, SSF4), and entropy (SSF4, SSF6) between disease-progressive group and disease-stable group (all P < 0.05). In DWI sequential images, there were significant differences in the texture parameters of means (SSF2, SSF4, SSF6), skewness (SSF4, SSF6), and kurtosis (SSF2, SSF4) between the two groups (all P < 0.05). Multivariate Cox regression analysis showed that the texture parameter of means (SSF2, SSF4, SSF6) of T2WI and the texture parameters of means (SSF2, SSF6), entropy (SSF2, SSF4, SSF6) and skewness (SSF4, SSF6) of DWI were correlated with the efficacy of chemoradiotherapy in patients with cervical squamous cell carcinoma (P < 0.05). The Results of ROC analysis showed that the texture parameter of means (T2WI-SSF2, T2WI-SSF4, T2WI-SSF6, DWI-SSF2, DWI-SSF6) and skewness (DWI-SSF6) could predict the progression of cervical squamous cell carcinoma after chemoradiotherapy in patients with cervical squamous cell carcinoma. The area under the curve (AUC) was 0.625-0.746. Among them, the mean of T2WI-SSF4 was the most effective (AUC: 0.746), followed by the mean of T2WI-SSF2 (AUC: 0.725) and the mean of T2WI-SSF6 (AUC: 0.703). Conclusions The texture parameters of baseline T2WI and DWI sequences were correlated with the curative effect of chemoradiotherapy in patients with cervical squamous cell carcinoma. The parameters of means and skewness can predict the progression of cervical squamous carcinoma after chemoradiotherapy, and the mean has a higher predictive power.
format	article
author	SU Baiyan QI Yafei GUAN Hui HE Yonglan XUE Huadan JIN Zhengyu
author_facet	SU Baiyan QI Yafei GUAN Hui HE Yonglan XUE Huadan JIN Zhengyu
author_sort	SU Baiyan
title	Texture Analysis of Sequential Images of T2-weighted Imaging and Diffusion-weighted Imaging for Predicting the Efficacy of Chemoradiotherapy in Cervical Squamous Cell Carcinoma
title_short	Texture Analysis of Sequential Images of T2-weighted Imaging and Diffusion-weighted Imaging for Predicting the Efficacy of Chemoradiotherapy in Cervical Squamous Cell Carcinoma
title_full	Texture Analysis of Sequential Images of T2-weighted Imaging and Diffusion-weighted Imaging for Predicting the Efficacy of Chemoradiotherapy in Cervical Squamous Cell Carcinoma
title_fullStr	Texture Analysis of Sequential Images of T2-weighted Imaging and Diffusion-weighted Imaging for Predicting the Efficacy of Chemoradiotherapy in Cervical Squamous Cell Carcinoma
title_full_unstemmed	Texture Analysis of Sequential Images of T2-weighted Imaging and Diffusion-weighted Imaging for Predicting the Efficacy of Chemoradiotherapy in Cervical Squamous Cell Carcinoma
title_sort	texture analysis of sequential images of t2-weighted imaging and diffusion-weighted imaging for predicting the efficacy of chemoradiotherapy in cervical squamous cell carcinoma
publisher	Editorial Office of Medical Journal of Peking Union Medical College Hospital
publishDate	2021
url	https://doaj.org/article/b799204d1a2e4397851060660987de19
work_keys_str_mv	AT subaiyan textureanalysisofsequentialimagesoft2weightedimaginganddiffusionweightedimagingforpredictingtheefficacyofchemoradiotherapyincervicalsquamouscellcarcinoma AT qiyafei textureanalysisofsequentialimagesoft2weightedimaginganddiffusionweightedimagingforpredictingtheefficacyofchemoradiotherapyincervicalsquamouscellcarcinoma AT guanhui textureanalysisofsequentialimagesoft2weightedimaginganddiffusionweightedimagingforpredictingtheefficacyofchemoradiotherapyincervicalsquamouscellcarcinoma AT heyonglan textureanalysisofsequentialimagesoft2weightedimaginganddiffusionweightedimagingforpredictingtheefficacyofchemoradiotherapyincervicalsquamouscellcarcinoma AT xuehuadan textureanalysisofsequentialimagesoft2weightedimaginganddiffusionweightedimagingforpredictingtheefficacyofchemoradiotherapyincervicalsquamouscellcarcinoma AT jinzhengyu textureanalysisofsequentialimagesoft2weightedimaginganddiffusionweightedimagingforpredictingtheefficacyofchemoradiotherapyincervicalsquamouscellcarcinoma
_version_	1718405983676399616

Texture Analysis of Sequential Images of T2-weighted Imaging and Diffusion-weighted Imaging for Predicting the Efficacy of Chemoradiotherapy in Cervical Squamous Cell Carcinoma

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