Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients

Abstract Many expect genome sequencing (GS) to become routine in patient care and preventive medicine, but uncertainties remain about its ability to motivate participants to improve health behaviors and the psychological impact of disclosing results. In a pilot trial with exploratory analyses, we ra...

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Autores principales: Kurt D. Christensen, Erica F. Schonman, Jill O. Robinson, J. Scott Roberts, Pamela M. Diamond, Kaitlyn B. Lee, Robert C. Green, Amy L. McGuire
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b79ae75876f14fea94621325471eb616
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spelling oai:doaj.org-article:b79ae75876f14fea94621325471eb6162021-12-02T16:35:01ZBehavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients10.1038/s41525-021-00236-22056-7944https://doaj.org/article/b79ae75876f14fea94621325471eb6162021-08-01T00:00:00Zhttps://doi.org/10.1038/s41525-021-00236-2https://doaj.org/toc/2056-7944Abstract Many expect genome sequencing (GS) to become routine in patient care and preventive medicine, but uncertainties remain about its ability to motivate participants to improve health behaviors and the psychological impact of disclosing results. In a pilot trial with exploratory analyses, we randomized 100 apparently healthy, primary-care participants and 100 cardiology participants to receive a review of their family histories of disease, either alone or in addition to GS analyses. GS results included polygenic risk information for eight cardiometabolic conditions. Overall, no differences were observed between the percentage of participants in the GS and control arms, who reported changes to health behaviors such as diet and exercise at 6 months post disclosure (48% vs. 36%, respectively, p = 0.104). In the GS arm, however, the odds of reporting a behavior change increased by 52% per high-risk polygenic prediction (p = 0.032). Mean anxiety and depression scores for GS and control arms had confidence intervals within equivalence margins of ±1.5. Mediation analyses suggested an indirect impact of GS on health behaviors by causing positive psychological responses (p ≤ 0.001). Findings suggest that GS did not distress participants. Future research on GS in more diverse populations is needed to confirm that it does not raise risks for psychological harms and to confirm the ability of polygenic risk predictions to motivate preventive behaviors.Kurt D. ChristensenErica F. SchonmanJill O. RobinsonJ. Scott RobertsPamela M. DiamondKaitlyn B. LeeRobert C. GreenAmy L. McGuireNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 6, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Genetics
QH426-470
spellingShingle Medicine
R
Genetics
QH426-470
Kurt D. Christensen
Erica F. Schonman
Jill O. Robinson
J. Scott Roberts
Pamela M. Diamond
Kaitlyn B. Lee
Robert C. Green
Amy L. McGuire
Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
description Abstract Many expect genome sequencing (GS) to become routine in patient care and preventive medicine, but uncertainties remain about its ability to motivate participants to improve health behaviors and the psychological impact of disclosing results. In a pilot trial with exploratory analyses, we randomized 100 apparently healthy, primary-care participants and 100 cardiology participants to receive a review of their family histories of disease, either alone or in addition to GS analyses. GS results included polygenic risk information for eight cardiometabolic conditions. Overall, no differences were observed between the percentage of participants in the GS and control arms, who reported changes to health behaviors such as diet and exercise at 6 months post disclosure (48% vs. 36%, respectively, p = 0.104). In the GS arm, however, the odds of reporting a behavior change increased by 52% per high-risk polygenic prediction (p = 0.032). Mean anxiety and depression scores for GS and control arms had confidence intervals within equivalence margins of ±1.5. Mediation analyses suggested an indirect impact of GS on health behaviors by causing positive psychological responses (p ≤ 0.001). Findings suggest that GS did not distress participants. Future research on GS in more diverse populations is needed to confirm that it does not raise risks for psychological harms and to confirm the ability of polygenic risk predictions to motivate preventive behaviors.
format article
author Kurt D. Christensen
Erica F. Schonman
Jill O. Robinson
J. Scott Roberts
Pamela M. Diamond
Kaitlyn B. Lee
Robert C. Green
Amy L. McGuire
author_facet Kurt D. Christensen
Erica F. Schonman
Jill O. Robinson
J. Scott Roberts
Pamela M. Diamond
Kaitlyn B. Lee
Robert C. Green
Amy L. McGuire
author_sort Kurt D. Christensen
title Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
title_short Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
title_full Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
title_fullStr Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
title_full_unstemmed Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
title_sort behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b79ae75876f14fea94621325471eb616
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