Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients

Abstract Many expect genome sequencing (GS) to become routine in patient care and preventive medicine, but uncertainties remain about its ability to motivate participants to improve health behaviors and the psychological impact of disclosing results. In a pilot trial with exploratory analyses, we ra...

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Autores principales:	Kurt D. Christensen, Erica F. Schonman, Jill O. Robinson, J. Scott Roberts, Pamela M. Diamond, Kaitlyn B. Lee, Robert C. Green, Amy L. McGuire
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/b79ae75876f14fea94621325471eb616
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spelling	oai:doaj.org-article:b79ae75876f14fea94621325471eb6162021-12-02T16:35:01ZBehavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients10.1038/s41525-021-00236-22056-7944https://doaj.org/article/b79ae75876f14fea94621325471eb6162021-08-01T00:00:00Zhttps://doi.org/10.1038/s41525-021-00236-2https://doaj.org/toc/2056-7944Abstract Many expect genome sequencing (GS) to become routine in patient care and preventive medicine, but uncertainties remain about its ability to motivate participants to improve health behaviors and the psychological impact of disclosing results. In a pilot trial with exploratory analyses, we randomized 100 apparently healthy, primary-care participants and 100 cardiology participants to receive a review of their family histories of disease, either alone or in addition to GS analyses. GS results included polygenic risk information for eight cardiometabolic conditions. Overall, no differences were observed between the percentage of participants in the GS and control arms, who reported changes to health behaviors such as diet and exercise at 6 months post disclosure (48% vs. 36%, respectively, p = 0.104). In the GS arm, however, the odds of reporting a behavior change increased by 52% per high-risk polygenic prediction (p = 0.032). Mean anxiety and depression scores for GS and control arms had confidence intervals within equivalence margins of ±1.5. Mediation analyses suggested an indirect impact of GS on health behaviors by causing positive psychological responses (p ≤ 0.001). Findings suggest that GS did not distress participants. Future research on GS in more diverse populations is needed to confirm that it does not raise risks for psychological harms and to confirm the ability of polygenic risk predictions to motivate preventive behaviors.Kurt D. ChristensenErica F. SchonmanJill O. RobinsonJ. Scott RobertsPamela M. DiamondKaitlyn B. LeeRobert C. GreenAmy L. McGuireNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 6, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Kurt D. Christensen Erica F. Schonman Jill O. Robinson J. Scott Roberts Pamela M. Diamond Kaitlyn B. Lee Robert C. Green Amy L. McGuire Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
description	Abstract Many expect genome sequencing (GS) to become routine in patient care and preventive medicine, but uncertainties remain about its ability to motivate participants to improve health behaviors and the psychological impact of disclosing results. In a pilot trial with exploratory analyses, we randomized 100 apparently healthy, primary-care participants and 100 cardiology participants to receive a review of their family histories of disease, either alone or in addition to GS analyses. GS results included polygenic risk information for eight cardiometabolic conditions. Overall, no differences were observed between the percentage of participants in the GS and control arms, who reported changes to health behaviors such as diet and exercise at 6 months post disclosure (48% vs. 36%, respectively, p = 0.104). In the GS arm, however, the odds of reporting a behavior change increased by 52% per high-risk polygenic prediction (p = 0.032). Mean anxiety and depression scores for GS and control arms had confidence intervals within equivalence margins of ±1.5. Mediation analyses suggested an indirect impact of GS on health behaviors by causing positive psychological responses (p ≤ 0.001). Findings suggest that GS did not distress participants. Future research on GS in more diverse populations is needed to confirm that it does not raise risks for psychological harms and to confirm the ability of polygenic risk predictions to motivate preventive behaviors.
format	article
author	Kurt D. Christensen Erica F. Schonman Jill O. Robinson J. Scott Roberts Pamela M. Diamond Kaitlyn B. Lee Robert C. Green Amy L. McGuire
author_facet	Kurt D. Christensen Erica F. Schonman Jill O. Robinson J. Scott Roberts Pamela M. Diamond Kaitlyn B. Lee Robert C. Green Amy L. McGuire
author_sort	Kurt D. Christensen
title	Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
title_short	Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
title_full	Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
title_fullStr	Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
title_full_unstemmed	Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
title_sort	behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b79ae75876f14fea94621325471eb616
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Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients

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