Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression

Macrophage activation is integral to innate immunity and inflammation, and involves transcriptome remodeling leading to the rapid upregulation of pro- and anti-inflammatory effector genes. Here the authors show that the negative elongation factor (NELF) complex controls the transcription of anti-inf...

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Autores principales:	Li Yu, Bin Zhang, Dinesh Deochand, Maria A. Sacta, Maddalena Coppo, Yingli Shang, Ziyi Guo, Xiaomin Zeng, David A. Rollins, Bowranigan Tharmalingam, Rong Li, Yurii Chinenov, Inez Rogatsky, Xiaoyu Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7a362703a864f72b486afd63dbb01f6
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spelling	oai:doaj.org-article:b7a362703a864f72b486afd63dbb01f62021-12-02T15:39:24ZNegative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression10.1038/s41467-020-16209-52041-1723https://doaj.org/article/b7a362703a864f72b486afd63dbb01f62020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16209-5https://doaj.org/toc/2041-1723Macrophage activation is integral to innate immunity and inflammation, and involves transcriptome remodeling leading to the rapid upregulation of pro- and anti-inflammatory effector genes. Here the authors show that the negative elongation factor (NELF) complex controls the transcription of anti-inflammatory genes through Pol II pause release.Li YuBin ZhangDinesh DeochandMaria A. SactaMaddalena CoppoYingli ShangZiyi GuoXiaomin ZengDavid A. RollinsBowranigan TharmalingamRong LiYurii ChinenovInez RogatskyXiaoyu HuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li Yu Bin Zhang Dinesh Deochand Maria A. Sacta Maddalena Coppo Yingli Shang Ziyi Guo Xiaomin Zeng David A. Rollins Bowranigan Tharmalingam Rong Li Yurii Chinenov Inez Rogatsky Xiaoyu Hu Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression
description	Macrophage activation is integral to innate immunity and inflammation, and involves transcriptome remodeling leading to the rapid upregulation of pro- and anti-inflammatory effector genes. Here the authors show that the negative elongation factor (NELF) complex controls the transcription of anti-inflammatory genes through Pol II pause release.
format	article
author	Li Yu Bin Zhang Dinesh Deochand Maria A. Sacta Maddalena Coppo Yingli Shang Ziyi Guo Xiaomin Zeng David A. Rollins Bowranigan Tharmalingam Rong Li Yurii Chinenov Inez Rogatsky Xiaoyu Hu
author_facet	Li Yu Bin Zhang Dinesh Deochand Maria A. Sacta Maddalena Coppo Yingli Shang Ziyi Guo Xiaomin Zeng David A. Rollins Bowranigan Tharmalingam Rong Li Yurii Chinenov Inez Rogatsky Xiaoyu Hu
author_sort	Li Yu
title	Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression
title_short	Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression
title_full	Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression
title_fullStr	Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression
title_full_unstemmed	Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression
title_sort	negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b7a362703a864f72b486afd63dbb01f6
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Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression

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