Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features

Research on racial and ethnic influence on breast cancer mortality is stymied by a lack of genomic studies in diverse populations. Here, the authors genomically interrogate 194 Nigerian breast cancers, unveiling molecular features that could explain the high mortality rate from breast cancer in an i...

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Autores principales:	Jason J. Pitt, Markus Riester, Yonglan Zheng, Toshio F. Yoshimatsu, Ayodele Sanni, Olayiwola Oluwasola, Artur Veloso, Emma Labrot, Shengfeng Wang, Abayomi Odetunde, Adeyinka Ademola, Babajide Okedere, Scott Mahan, Rebecca Leary, Maura Macomber, Mustapha Ajani, Ryan S. Johnson, Dominic Fitzgerald, A. Jason Grundstad, Jigyasa H. Tuteja, Galina Khramtsova, Jing Zhang, Elisabeth Sveen, Bryce Hwang, Wendy Clayton, Chibuzor Nkwodimmah, Bisola Famooto, Esther Obasi, Victor Aderoju, Mobolaji Oludara, Folusho Omodele, Odunayo Akinyele, Adewunmi Adeoye, Temidayo Ogundiran, Chinedum Babalola, Kenzie MacIsaac, Abiodun Popoola, Michael P. Morrissey, Lin S. Chen, Jiebiao Wang, Christopher O. Olopade, Adeyinka G. Falusi, Wendy Winckler, Kerstin Haase, Peter Van Loo, John Obafunwa, Dimitris Papoutsakis, Oladosu Ojengbede, Barbara Weber, Nasiru Ibrahim, Kevin P. White, Dezheng Huo, Olufunmilayo I. Olopade, Jordi Barretina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7a3f3164f4543798d357434bd2c072e
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spelling	oai:doaj.org-article:b7a3f3164f4543798d357434bd2c072e2021-12-02T15:34:50ZCharacterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features10.1038/s41467-018-06616-02041-1723https://doaj.org/article/b7a3f3164f4543798d357434bd2c072e2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06616-0https://doaj.org/toc/2041-1723Research on racial and ethnic influence on breast cancer mortality is stymied by a lack of genomic studies in diverse populations. Here, the authors genomically interrogate 194 Nigerian breast cancers, unveiling molecular features that could explain the high mortality rate from breast cancer in an indigenous African population.Jason J. PittMarkus RiesterYonglan ZhengToshio F. YoshimatsuAyodele SanniOlayiwola OluwasolaArtur VelosoEmma LabrotShengfeng WangAbayomi OdetundeAdeyinka AdemolaBabajide OkedereScott MahanRebecca LearyMaura MacomberMustapha AjaniRyan S. JohnsonDominic FitzgeraldA. Jason GrundstadJigyasa H. TutejaGalina KhramtsovaJing ZhangElisabeth SveenBryce HwangWendy ClaytonChibuzor NkwodimmahBisola FamootoEsther ObasiVictor AderojuMobolaji OludaraFolusho OmodeleOdunayo AkinyeleAdewunmi AdeoyeTemidayo OgundiranChinedum BabalolaKenzie MacIsaacAbiodun PopoolaMichael P. MorrisseyLin S. ChenJiebiao WangChristopher O. OlopadeAdeyinka G. FalusiWendy WincklerKerstin HaasePeter Van LooJohn ObafunwaDimitris PapoutsakisOladosu OjengbedeBarbara WeberNasiru IbrahimKevin P. WhiteDezheng HuoOlufunmilayo I. OlopadeJordi BarretinaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason J. Pitt Markus Riester Yonglan Zheng Toshio F. Yoshimatsu Ayodele Sanni Olayiwola Oluwasola Artur Veloso Emma Labrot Shengfeng Wang Abayomi Odetunde Adeyinka Ademola Babajide Okedere Scott Mahan Rebecca Leary Maura Macomber Mustapha Ajani Ryan S. Johnson Dominic Fitzgerald A. Jason Grundstad Jigyasa H. Tuteja Galina Khramtsova Jing Zhang Elisabeth Sveen Bryce Hwang Wendy Clayton Chibuzor Nkwodimmah Bisola Famooto Esther Obasi Victor Aderoju Mobolaji Oludara Folusho Omodele Odunayo Akinyele Adewunmi Adeoye Temidayo Ogundiran Chinedum Babalola Kenzie MacIsaac Abiodun Popoola Michael P. Morrissey Lin S. Chen Jiebiao Wang Christopher O. Olopade Adeyinka G. Falusi Wendy Winckler Kerstin Haase Peter Van Loo John Obafunwa Dimitris Papoutsakis Oladosu Ojengbede Barbara Weber Nasiru Ibrahim Kevin P. White Dezheng Huo Olufunmilayo I. Olopade Jordi Barretina Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features
description	Research on racial and ethnic influence on breast cancer mortality is stymied by a lack of genomic studies in diverse populations. Here, the authors genomically interrogate 194 Nigerian breast cancers, unveiling molecular features that could explain the high mortality rate from breast cancer in an indigenous African population.
format	article
author	Jason J. Pitt Markus Riester Yonglan Zheng Toshio F. Yoshimatsu Ayodele Sanni Olayiwola Oluwasola Artur Veloso Emma Labrot Shengfeng Wang Abayomi Odetunde Adeyinka Ademola Babajide Okedere Scott Mahan Rebecca Leary Maura Macomber Mustapha Ajani Ryan S. Johnson Dominic Fitzgerald A. Jason Grundstad Jigyasa H. Tuteja Galina Khramtsova Jing Zhang Elisabeth Sveen Bryce Hwang Wendy Clayton Chibuzor Nkwodimmah Bisola Famooto Esther Obasi Victor Aderoju Mobolaji Oludara Folusho Omodele Odunayo Akinyele Adewunmi Adeoye Temidayo Ogundiran Chinedum Babalola Kenzie MacIsaac Abiodun Popoola Michael P. Morrissey Lin S. Chen Jiebiao Wang Christopher O. Olopade Adeyinka G. Falusi Wendy Winckler Kerstin Haase Peter Van Loo John Obafunwa Dimitris Papoutsakis Oladosu Ojengbede Barbara Weber Nasiru Ibrahim Kevin P. White Dezheng Huo Olufunmilayo I. Olopade Jordi Barretina
author_facet	Jason J. Pitt Markus Riester Yonglan Zheng Toshio F. Yoshimatsu Ayodele Sanni Olayiwola Oluwasola Artur Veloso Emma Labrot Shengfeng Wang Abayomi Odetunde Adeyinka Ademola Babajide Okedere Scott Mahan Rebecca Leary Maura Macomber Mustapha Ajani Ryan S. Johnson Dominic Fitzgerald A. Jason Grundstad Jigyasa H. Tuteja Galina Khramtsova Jing Zhang Elisabeth Sveen Bryce Hwang Wendy Clayton Chibuzor Nkwodimmah Bisola Famooto Esther Obasi Victor Aderoju Mobolaji Oludara Folusho Omodele Odunayo Akinyele Adewunmi Adeoye Temidayo Ogundiran Chinedum Babalola Kenzie MacIsaac Abiodun Popoola Michael P. Morrissey Lin S. Chen Jiebiao Wang Christopher O. Olopade Adeyinka G. Falusi Wendy Winckler Kerstin Haase Peter Van Loo John Obafunwa Dimitris Papoutsakis Oladosu Ojengbede Barbara Weber Nasiru Ibrahim Kevin P. White Dezheng Huo Olufunmilayo I. Olopade Jordi Barretina
author_sort	Jason J. Pitt
title	Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features
title_short	Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features
title_full	Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features
title_fullStr	Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features
title_full_unstemmed	Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features
title_sort	characterization of nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b7a3f3164f4543798d357434bd2c072e
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Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features

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