Circulating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.

<h4>Background</h4>Obstructive sleep apnea (OSA) patients are at increased risk of cardiovascular disease (CVD). Cell adhesion molecules (CAM) are increased in OSA and CAM are also implicated in the development of CVD.<h4>Research question</h4>Do CAM (ICAM-1, VCAM-1 and E-sel...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bernardo U Peres, A J Hirsch Allen, Patrick Daniele, Karin H Humphries, Carolyn Taylor, Ismail Laher, Fernanda Almeida, Rachel Jen, Andrew J Sandford, Stephan F van Eeden, Najib T Ayas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7a702fe1bcf44c6b8da2205459e5afd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b7a702fe1bcf44c6b8da2205459e5afd
record_format	dspace
spelling	oai:doaj.org-article:b7a702fe1bcf44c6b8da2205459e5afd2021-12-02T20:08:49ZCirculating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.1932-620310.1371/journal.pone.0255306https://doaj.org/article/b7a702fe1bcf44c6b8da2205459e5afd2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255306https://doaj.org/toc/1932-6203<h4>Background</h4>Obstructive sleep apnea (OSA) patients are at increased risk of cardiovascular disease (CVD). Cell adhesion molecules (CAM) are increased in OSA and CAM are also implicated in the development of CVD.<h4>Research question</h4>Do CAM (ICAM-1, VCAM-1 and E-selectin) have prognostic value in identifying risk of cardiovascular events in OSA?<h4>Study design and methods</h4>Patients with suspected OSA referred for a polysomnogram provided a fasting blood sample. Plasma levels of ICAM-1, VCAM-1 and E-selectin were determined by multiplex Luminex Assay (Milliporesigma ON, Canada). Cardiovascular events were determined by deterministic linkage to provincial health databases.<h4>Results</h4>418 patients were included in the analysis. Mostly male (68.2%), mean age of 50.7 yrs, median AHI 16.5 events/hour, and mean BMI of 31.7 kg/m2. 36 cardiovascular events occurred in 8-yrs of follow up. Higher levels of ICAM-1 were associated with developing CVD (HR = 3.65 95% CI 1.40-9.53, 2nd and 3rd tertiles vs. 1st tertile), including in patients with OSA (HR = 3.1 95% CI 1.16-8.25). E-selectin was significantly associated with cardiovascular events in patients with moderate to severe OSA (HR = 3.31 95% CI 0.94-11.72, 2nd and 3rd tertiles vs. 1st tertile) but not in patients without moderate to severe OSA (HR = 0.67 95% CI 0.19-2.38), p-value for interaction = 0.07.<h4>Interpretation</h4>In a suspected OSA cohort, patients with higher levels of ICAM-1 (>816 ng/ml) were significantly more likely to experience a cardiovascular event within 8 years after PSG. In moderate to severe OSA patients, a higher E-selectin (>36.4 ng/ml) was significantly associated with cardiovascular events.Bernardo U PeresA J Hirsch AllenPatrick DanieleKarin H HumphriesCarolyn TaylorIsmail LaherFernanda AlmeidaRachel JenAndrew J SandfordStephan F van EedenNajib T AyasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255306 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bernardo U Peres A J Hirsch Allen Patrick Daniele Karin H Humphries Carolyn Taylor Ismail Laher Fernanda Almeida Rachel Jen Andrew J Sandford Stephan F van Eeden Najib T Ayas Circulating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.
description	<h4>Background</h4>Obstructive sleep apnea (OSA) patients are at increased risk of cardiovascular disease (CVD). Cell adhesion molecules (CAM) are increased in OSA and CAM are also implicated in the development of CVD.<h4>Research question</h4>Do CAM (ICAM-1, VCAM-1 and E-selectin) have prognostic value in identifying risk of cardiovascular events in OSA?<h4>Study design and methods</h4>Patients with suspected OSA referred for a polysomnogram provided a fasting blood sample. Plasma levels of ICAM-1, VCAM-1 and E-selectin were determined by multiplex Luminex Assay (Milliporesigma ON, Canada). Cardiovascular events were determined by deterministic linkage to provincial health databases.<h4>Results</h4>418 patients were included in the analysis. Mostly male (68.2%), mean age of 50.7 yrs, median AHI 16.5 events/hour, and mean BMI of 31.7 kg/m2. 36 cardiovascular events occurred in 8-yrs of follow up. Higher levels of ICAM-1 were associated with developing CVD (HR = 3.65 95% CI 1.40-9.53, 2nd and 3rd tertiles vs. 1st tertile), including in patients with OSA (HR = 3.1 95% CI 1.16-8.25). E-selectin was significantly associated with cardiovascular events in patients with moderate to severe OSA (HR = 3.31 95% CI 0.94-11.72, 2nd and 3rd tertiles vs. 1st tertile) but not in patients without moderate to severe OSA (HR = 0.67 95% CI 0.19-2.38), p-value for interaction = 0.07.<h4>Interpretation</h4>In a suspected OSA cohort, patients with higher levels of ICAM-1 (>816 ng/ml) were significantly more likely to experience a cardiovascular event within 8 years after PSG. In moderate to severe OSA patients, a higher E-selectin (>36.4 ng/ml) was significantly associated with cardiovascular events.
format	article
author	Bernardo U Peres A J Hirsch Allen Patrick Daniele Karin H Humphries Carolyn Taylor Ismail Laher Fernanda Almeida Rachel Jen Andrew J Sandford Stephan F van Eeden Najib T Ayas
author_facet	Bernardo U Peres A J Hirsch Allen Patrick Daniele Karin H Humphries Carolyn Taylor Ismail Laher Fernanda Almeida Rachel Jen Andrew J Sandford Stephan F van Eeden Najib T Ayas
author_sort	Bernardo U Peres
title	Circulating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.
title_short	Circulating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.
title_full	Circulating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.
title_fullStr	Circulating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.
title_full_unstemmed	Circulating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.
title_sort	circulating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b7a702fe1bcf44c6b8da2205459e5afd
work_keys_str_mv	AT bernardouperes circulatinglevelsofcelladhesionmoleculesandriskofcardiovasculareventsinobstructivesleepapnea AT ajhirschallen circulatinglevelsofcelladhesionmoleculesandriskofcardiovasculareventsinobstructivesleepapnea AT patrickdaniele circulatinglevelsofcelladhesionmoleculesandriskofcardiovasculareventsinobstructivesleepapnea AT karinhhumphries circulatinglevelsofcelladhesionmoleculesandriskofcardiovasculareventsinobstructivesleepapnea AT carolyntaylor circulatinglevelsofcelladhesionmoleculesandriskofcardiovasculareventsinobstructivesleepapnea AT ismaillaher circulatinglevelsofcelladhesionmoleculesandriskofcardiovasculareventsinobstructivesleepapnea AT fernandaalmeida circulatinglevelsofcelladhesionmoleculesandriskofcardiovasculareventsinobstructivesleepapnea AT racheljen circulatinglevelsofcelladhesionmoleculesandriskofcardiovasculareventsinobstructivesleepapnea AT andrewjsandford circulatinglevelsofcelladhesionmoleculesandriskofcardiovasculareventsinobstructivesleepapnea AT stephanfvaneeden circulatinglevelsofcelladhesionmoleculesandriskofcardiovasculareventsinobstructivesleepapnea AT najibtayas circulatinglevelsofcelladhesionmoleculesandriskofcardiovasculareventsinobstructivesleepapnea
_version_	1718375146848256000

Circulating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.

Ejemplares similares