Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission

Drp1 and Dnm2 have been implicated in mitochondrial fission events, although their specific activities in constriction and scission have been unclear. Here, the authors demonstrate that Drp1 is sufficient to constrict and sever mitochondrial and peroxisomal membranes in the absence of Dnm proteins.

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Autores principales:	Sukrut C. Kamerkar, Felix Kraus, Alice J. Sharpe, Thomas J. Pucadyil, Michael T. Ryan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7aa83849104458696ba607a842a6b41
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spelling	oai:doaj.org-article:b7aa83849104458696ba607a842a6b412021-12-02T16:49:50ZDynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission10.1038/s41467-018-07543-w2041-1723https://doaj.org/article/b7aa83849104458696ba607a842a6b412018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07543-whttps://doaj.org/toc/2041-1723Drp1 and Dnm2 have been implicated in mitochondrial fission events, although their specific activities in constriction and scission have been unclear. Here, the authors demonstrate that Drp1 is sufficient to constrict and sever mitochondrial and peroxisomal membranes in the absence of Dnm proteins.Sukrut C. KamerkarFelix KrausAlice J. SharpeThomas J. PucadyilMichael T. RyanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sukrut C. Kamerkar Felix Kraus Alice J. Sharpe Thomas J. Pucadyil Michael T. Ryan Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission
description	Drp1 and Dnm2 have been implicated in mitochondrial fission events, although their specific activities in constriction and scission have been unclear. Here, the authors demonstrate that Drp1 is sufficient to constrict and sever mitochondrial and peroxisomal membranes in the absence of Dnm proteins.
format	article
author	Sukrut C. Kamerkar Felix Kraus Alice J. Sharpe Thomas J. Pucadyil Michael T. Ryan
author_facet	Sukrut C. Kamerkar Felix Kraus Alice J. Sharpe Thomas J. Pucadyil Michael T. Ryan
author_sort	Sukrut C. Kamerkar
title	Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission
title_short	Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission
title_full	Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission
title_fullStr	Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission
title_full_unstemmed	Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission
title_sort	dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b7aa83849104458696ba607a842a6b41
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Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission

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