Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats

Abstract The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells. The development and progression of diabetes generate a mild cognitive impai...

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Autores principales:	Marzia Soligo, Sonia Piccinin, Virginia Protto, Francesca Gelfo, Maria Egle De Stefano, Fulvio Florenzano, Erica Berretta, Laura Petrosini, Robert Nisticò, Luigi Manni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7ac817b23ce4e5da5be57d43e6f9e1b
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spelling	oai:doaj.org-article:b7ac817b23ce4e5da5be57d43e6f9e1b2021-12-02T16:06:16ZRecovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats10.1038/s41598-017-08556-z2045-2322https://doaj.org/article/b7ac817b23ce4e5da5be57d43e6f9e1b2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08556-zhttps://doaj.org/toc/2045-2322Abstract The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells. The development and progression of diabetes generate a mild cognitive impairment reducing the functions of the septo-hippocampal cholinergic circuitry, depressing neural plasticity and inducing proNGF accumulation in the brain. Here we demonstrate, in a rat model of early type-1 diabetes, that a physical therapy, the electroacupuncture, counteracts the diabetes-induced deleterious effects on hippocampal physiology by ameliorating hippocampal-related memory functions; recovering the impaired long-term potentiation at the dentate gyrus (DG-LTP) and the lowered expression of the vesicular glutamate transporter 1; normalizing the activity-dependent release of proNGF in diabetic rat hippocampus. Electroacupuncture exerted its therapeutic effects by regulating the expression and activity of M1- and M2-acetylcholine muscarinic receptors subtypes in the dentate gyrus of hippocampus. Our results suggest that a physical therapy based on repetitive sensory stimulation could promote hippocampal neural activity, neuronal metabolism and functions, and conceivably improve the diabetes-induced cognitive impairment. Our data can support the setup of therapeutic protocols based on a better integration between physical therapies and pharmacology for the cure of diabetes-associated neurodegeneration and possibly for Alzheimer’s disease.Marzia SoligoSonia PiccininVirginia ProttoFrancesca GelfoMaria Egle De StefanoFulvio FlorenzanoErica BerrettaLaura PetrosiniRobert NisticòLuigi ManniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marzia Soligo Sonia Piccinin Virginia Protto Francesca Gelfo Maria Egle De Stefano Fulvio Florenzano Erica Berretta Laura Petrosini Robert Nisticò Luigi Manni Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats
description	Abstract The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells. The development and progression of diabetes generate a mild cognitive impairment reducing the functions of the septo-hippocampal cholinergic circuitry, depressing neural plasticity and inducing proNGF accumulation in the brain. Here we demonstrate, in a rat model of early type-1 diabetes, that a physical therapy, the electroacupuncture, counteracts the diabetes-induced deleterious effects on hippocampal physiology by ameliorating hippocampal-related memory functions; recovering the impaired long-term potentiation at the dentate gyrus (DG-LTP) and the lowered expression of the vesicular glutamate transporter 1; normalizing the activity-dependent release of proNGF in diabetic rat hippocampus. Electroacupuncture exerted its therapeutic effects by regulating the expression and activity of M1- and M2-acetylcholine muscarinic receptors subtypes in the dentate gyrus of hippocampus. Our results suggest that a physical therapy based on repetitive sensory stimulation could promote hippocampal neural activity, neuronal metabolism and functions, and conceivably improve the diabetes-induced cognitive impairment. Our data can support the setup of therapeutic protocols based on a better integration between physical therapies and pharmacology for the cure of diabetes-associated neurodegeneration and possibly for Alzheimer’s disease.
format	article
author	Marzia Soligo Sonia Piccinin Virginia Protto Francesca Gelfo Maria Egle De Stefano Fulvio Florenzano Erica Berretta Laura Petrosini Robert Nisticò Luigi Manni
author_facet	Marzia Soligo Sonia Piccinin Virginia Protto Francesca Gelfo Maria Egle De Stefano Fulvio Florenzano Erica Berretta Laura Petrosini Robert Nisticò Luigi Manni
author_sort	Marzia Soligo
title	Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats
title_short	Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats
title_full	Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats
title_fullStr	Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats
title_full_unstemmed	Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats
title_sort	recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b7ac817b23ce4e5da5be57d43e6f9e1b
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_version_	1718385048920522752

Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats

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