Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents

Sterylglucosidase 1 (Sgl1) is a virulence factor in Cryptococcus neoformans that modulates fungal pathogenesis and host response. Here, the authors characterize Sgl1 structurally, identify Sgl1 inhibitors, and demonstrate Sgl1 inhibition has efficacy in mouse models of infection.

Guardado en:

Detalles Bibliográficos
Autores principales:	Nivea Pereira de Sa, Adam Taouil, Jinwoo Kim, Timothy Clement, Reece M. Hoffmann, John E. Burke, Robert C. Rizzo, Iwao Ojima, Maurizio Del Poeta, Michael V. Airola
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7ad82af9ed844d79dd8c233ece7e3ff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b7ad82af9ed844d79dd8c233ece7e3ff
record_format	dspace
spelling	oai:doaj.org-article:b7ad82af9ed844d79dd8c233ece7e3ff2021-12-02T19:16:20ZStructure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents10.1038/s41467-021-26163-52041-1723https://doaj.org/article/b7ad82af9ed844d79dd8c233ece7e3ff2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26163-5https://doaj.org/toc/2041-1723Sterylglucosidase 1 (Sgl1) is a virulence factor in Cryptococcus neoformans that modulates fungal pathogenesis and host response. Here, the authors characterize Sgl1 structurally, identify Sgl1 inhibitors, and demonstrate Sgl1 inhibition has efficacy in mouse models of infection.Nivea Pereira de SaAdam TaouilJinwoo KimTimothy ClementReece M. HoffmannJohn E. BurkeRobert C. RizzoIwao OjimaMaurizio Del PoetaMichael V. AirolaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nivea Pereira de Sa Adam Taouil Jinwoo Kim Timothy Clement Reece M. Hoffmann John E. Burke Robert C. Rizzo Iwao Ojima Maurizio Del Poeta Michael V. Airola Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents
description	Sterylglucosidase 1 (Sgl1) is a virulence factor in Cryptococcus neoformans that modulates fungal pathogenesis and host response. Here, the authors characterize Sgl1 structurally, identify Sgl1 inhibitors, and demonstrate Sgl1 inhibition has efficacy in mouse models of infection.
format	article
author	Nivea Pereira de Sa Adam Taouil Jinwoo Kim Timothy Clement Reece M. Hoffmann John E. Burke Robert C. Rizzo Iwao Ojima Maurizio Del Poeta Michael V. Airola
author_facet	Nivea Pereira de Sa Adam Taouil Jinwoo Kim Timothy Clement Reece M. Hoffmann John E. Burke Robert C. Rizzo Iwao Ojima Maurizio Del Poeta Michael V. Airola
author_sort	Nivea Pereira de Sa
title	Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents
title_short	Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents
title_full	Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents
title_fullStr	Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents
title_full_unstemmed	Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents
title_sort	structure and inhibition of cryptococcus neoformans sterylglucosidase to develop antifungal agents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b7ad82af9ed844d79dd8c233ece7e3ff
work_keys_str_mv	AT niveapereiradesa structureandinhibitionofcryptococcusneoformanssterylglucosidasetodevelopantifungalagents AT adamtaouil structureandinhibitionofcryptococcusneoformanssterylglucosidasetodevelopantifungalagents AT jinwookim structureandinhibitionofcryptococcusneoformanssterylglucosidasetodevelopantifungalagents AT timothyclement structureandinhibitionofcryptococcusneoformanssterylglucosidasetodevelopantifungalagents AT reecemhoffmann structureandinhibitionofcryptococcusneoformanssterylglucosidasetodevelopantifungalagents AT johneburke structureandinhibitionofcryptococcusneoformanssterylglucosidasetodevelopantifungalagents AT robertcrizzo structureandinhibitionofcryptococcusneoformanssterylglucosidasetodevelopantifungalagents AT iwaoojima structureandinhibitionofcryptococcusneoformanssterylglucosidasetodevelopantifungalagents AT mauriziodelpoeta structureandinhibitionofcryptococcusneoformanssterylglucosidasetodevelopantifungalagents AT michaelvairola structureandinhibitionofcryptococcusneoformanssterylglucosidasetodevelopantifungalagents
_version_	1718376992754106368

Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents

Ejemplares similares