Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents

Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents

Sterylglucosidase 1 (Sgl1) is a virulence factor in Cryptococcus neoformans that modulates fungal pathogenesis and host response. Here, the authors characterize Sgl1 structurally, identify Sgl1 inhibitors, and demonstrate Sgl1 inhibition has efficacy in mouse models of infection.

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Autores principales: Nivea Pereira de Sa, Adam Taouil, Jinwoo Kim, Timothy Clement, Reece M. Hoffmann, John E. Burke, Robert C. Rizzo, Iwao Ojima, Maurizio Del Poeta, Michael V. Airola
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/b7ad82af9ed844d79dd8c233ece7e3ff
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