IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.

Overnutrition caused by overeating is associated with insulin and leptin resistance through IKKbeta activation and endoplasmic reticulum (ER) stress in the hypothalamus. Here we show that physical exercise suppresses hyperphagia and associated hypothalamic IKKbeta/NF-kappaB activation by a mechanism...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eduardo R Ropelle, Marcelo B Flores, Dennys E Cintra, Guilherme Z Rocha, José R Pauli, Joseane Morari, Claudio T de Souza, Juliana C Moraes, Patrícia O Prada, Dioze Guadagnini, Rodrigo M Marin, Alexandre G Oliveira, Taize M Augusto, Hernandes F Carvalho, Lício A Velloso, Mario J A Saad, José B C Carvalheira
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b7aefd17028b4467b5236c482917b926
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b7aefd17028b4467b5236c482917b926
record_format	dspace
spelling	oai:doaj.org-article:b7aefd17028b4467b5236c482917b9262021-11-18T05:34:53ZIL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.1544-91731545-788510.1371/journal.pbio.1000465https://doaj.org/article/b7aefd17028b4467b5236c482917b9262010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808781/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Overnutrition caused by overeating is associated with insulin and leptin resistance through IKKbeta activation and endoplasmic reticulum (ER) stress in the hypothalamus. Here we show that physical exercise suppresses hyperphagia and associated hypothalamic IKKbeta/NF-kappaB activation by a mechanism dependent upon the pro-inflammatory cytokine interleukin (IL)-6. The disruption of hypothalamic-specific IL-6 action blocked the beneficial effects of exercise on the re-balance of food intake and insulin and leptin resistance. This molecular mechanism, mediated by physical activity, involves the anti-inflammatory protein IL-10, a core inhibitor of IKKbeta/NF-kappaB signaling and ER stress. We report that exercise and recombinant IL-6 requires IL-10 expression to suppress hyperphagia-related obesity. Moreover, in contrast to control mice, exercise failed to reverse the pharmacological activation of IKKbeta and ER stress in C3H/HeJ mice deficient in hypothalamic IL-6 and IL-10 signaling. Hence, inflammatory signaling in the hypothalamus links beneficial physiological effects of exercise to the central action of insulin and leptin.Eduardo R RopelleMarcelo B FloresDennys E CintraGuilherme Z RochaJosé R PauliJoseane MorariClaudio T de SouzaJuliana C MoraesPatrícia O PradaDioze GuadagniniRodrigo M MarinAlexandre G OliveiraTaize M AugustoHernandes F CarvalhoLício A VellosoMario J A SaadJosé B C CarvalheiraPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 8, Iss 8 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Eduardo R Ropelle Marcelo B Flores Dennys E Cintra Guilherme Z Rocha José R Pauli Joseane Morari Claudio T de Souza Juliana C Moraes Patrícia O Prada Dioze Guadagnini Rodrigo M Marin Alexandre G Oliveira Taize M Augusto Hernandes F Carvalho Lício A Velloso Mario J A Saad José B C Carvalheira IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.
description	Overnutrition caused by overeating is associated with insulin and leptin resistance through IKKbeta activation and endoplasmic reticulum (ER) stress in the hypothalamus. Here we show that physical exercise suppresses hyperphagia and associated hypothalamic IKKbeta/NF-kappaB activation by a mechanism dependent upon the pro-inflammatory cytokine interleukin (IL)-6. The disruption of hypothalamic-specific IL-6 action blocked the beneficial effects of exercise on the re-balance of food intake and insulin and leptin resistance. This molecular mechanism, mediated by physical activity, involves the anti-inflammatory protein IL-10, a core inhibitor of IKKbeta/NF-kappaB signaling and ER stress. We report that exercise and recombinant IL-6 requires IL-10 expression to suppress hyperphagia-related obesity. Moreover, in contrast to control mice, exercise failed to reverse the pharmacological activation of IKKbeta and ER stress in C3H/HeJ mice deficient in hypothalamic IL-6 and IL-10 signaling. Hence, inflammatory signaling in the hypothalamus links beneficial physiological effects of exercise to the central action of insulin and leptin.
format	article
author	Eduardo R Ropelle Marcelo B Flores Dennys E Cintra Guilherme Z Rocha José R Pauli Joseane Morari Claudio T de Souza Juliana C Moraes Patrícia O Prada Dioze Guadagnini Rodrigo M Marin Alexandre G Oliveira Taize M Augusto Hernandes F Carvalho Lício A Velloso Mario J A Saad José B C Carvalheira
author_facet	Eduardo R Ropelle Marcelo B Flores Dennys E Cintra Guilherme Z Rocha José R Pauli Joseane Morari Claudio T de Souza Juliana C Moraes Patrícia O Prada Dioze Guadagnini Rodrigo M Marin Alexandre G Oliveira Taize M Augusto Hernandes F Carvalho Lício A Velloso Mario J A Saad José B C Carvalheira
author_sort	Eduardo R Ropelle
title	IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.
title_short	IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.
title_full	IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.
title_fullStr	IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.
title_full_unstemmed	IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.
title_sort	il-6 and il-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through ikkbeta and er stress inhibition.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/b7aefd17028b4467b5236c482917b926
work_keys_str_mv	AT eduardorropelle il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT marcelobflores il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT dennysecintra il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT guilhermezrocha il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT joserpauli il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT joseanemorari il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT claudiotdesouza il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT julianacmoraes il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT patriciaoprada il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT diozeguadagnini il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT rodrigommarin il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT alexandregoliveira il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT taizemaugusto il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT hernandesfcarvalho il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT licioavelloso il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT mariojasaad il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition AT josebccarvalheira il6andil10antiinflammatoryactivitylinksexercisetohypothalamicinsulinandleptinsensitivitythroughikkbetaanderstressinhibition
_version_	1718424934843154432

IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.

Ejemplares similares