IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.

IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.

Overnutrition caused by overeating is associated with insulin and leptin resistance through IKKbeta activation and endoplasmic reticulum (ER) stress in the hypothalamus. Here we show that physical exercise suppresses hyperphagia and associated hypothalamic IKKbeta/NF-kappaB activation by a mechanism...

Full description

Saved in:
Bibliographic Details
Main Authors: Eduardo R Ropelle, Marcelo B Flores, Dennys E Cintra, Guilherme Z Rocha, José R Pauli, Joseane Morari, Claudio T de Souza, Juliana C Moraes, Patrícia O Prada, Dioze Guadagnini, Rodrigo M Marin, Alexandre G Oliveira, Taize M Augusto, Hernandes F Carvalho, Lício A Velloso, Mario J A Saad, José B C Carvalheira
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/b7aefd17028b4467b5236c482917b926
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/b7aefd17028b4467b5236c482917b926

Similar Items