Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?

Animal model studies and first clinical trials have demonstrated the safety and efficacy of the mesenchymal stem cells’ (MSCs) transplantation in stroke. Intra-arterial (IA) administration looks especially promising, since it provides targeted cell delivery to the ischemic brain, is highly effective...

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Autores principales:	Konstantin N. Yarygin, Daria D. Namestnikova, Kirill K. Sukhinich, Ilya L. Gubskiy, Alexander G. Majouga, Irina V. Kholodenko
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mesenchymal stem cells cell therapy stroke blood–brain barrier neurovascular unit stroke models Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b7afa2ef486749e995d051deb9667305
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spelling	oai:doaj.org-article:b7afa2ef486749e995d051deb96673052021-11-25T17:10:14ZCell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?10.3390/cells101129972073-4409https://doaj.org/article/b7afa2ef486749e995d051deb96673052021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2997https://doaj.org/toc/2073-4409Animal model studies and first clinical trials have demonstrated the safety and efficacy of the mesenchymal stem cells’ (MSCs) transplantation in stroke. Intra-arterial (IA) administration looks especially promising, since it provides targeted cell delivery to the ischemic brain, is highly effective, and can be safe as long as the infusion is conducted appropriately. However, wider clinical application of the IA MSCs transplantation will only be possible after a better understanding of the mechanism of their therapeutic action is achieved. On the way to achieve this goal, the study of transplanted cells’ fate and their interactions with the blood–brain barrier (BBB) structures could be one of the key factors. In this review, we analyze the available data concerning one of the most important aspects of the transplanted MSCs’ action—the ability of cells to cross the blood–brain barrier (BBB) in vitro and in vivo after IA administration into animals with experimental stroke. The collected data show that some of the transplanted MSCs temporarily attach to the walls of the cerebral vessels and then return to the bloodstream or penetrate the BBB and either undergo homing in the perivascular space or penetrate deeper into the parenchyma. Transmigration across the BBB is not necessary for the induction of therapeutic effects, which can be incited through a paracrine mechanism even by cells located inside the blood vessels.Konstantin N. YaryginDaria D. NamestnikovaKirill K. SukhinichIlya L. GubskiyAlexander G. MajougaIrina V. KholodenkoMDPI AGarticlemesenchymal stem cellscell therapystrokeblood–brain barrierneurovascular unitstroke modelsBiology (General)QH301-705.5ENCells, Vol 10, Iss 2997, p 2997 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesenchymal stem cells cell therapy stroke blood–brain barrier neurovascular unit stroke models Biology (General) QH301-705.5
spellingShingle	mesenchymal stem cells cell therapy stroke blood–brain barrier neurovascular unit stroke models Biology (General) QH301-705.5 Konstantin N. Yarygin Daria D. Namestnikova Kirill K. Sukhinich Ilya L. Gubskiy Alexander G. Majouga Irina V. Kholodenko Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?
description	Animal model studies and first clinical trials have demonstrated the safety and efficacy of the mesenchymal stem cells’ (MSCs) transplantation in stroke. Intra-arterial (IA) administration looks especially promising, since it provides targeted cell delivery to the ischemic brain, is highly effective, and can be safe as long as the infusion is conducted appropriately. However, wider clinical application of the IA MSCs transplantation will only be possible after a better understanding of the mechanism of their therapeutic action is achieved. On the way to achieve this goal, the study of transplanted cells’ fate and their interactions with the blood–brain barrier (BBB) structures could be one of the key factors. In this review, we analyze the available data concerning one of the most important aspects of the transplanted MSCs’ action—the ability of cells to cross the blood–brain barrier (BBB) in vitro and in vivo after IA administration into animals with experimental stroke. The collected data show that some of the transplanted MSCs temporarily attach to the walls of the cerebral vessels and then return to the bloodstream or penetrate the BBB and either undergo homing in the perivascular space or penetrate deeper into the parenchyma. Transmigration across the BBB is not necessary for the induction of therapeutic effects, which can be incited through a paracrine mechanism even by cells located inside the blood vessels.
format	article
author	Konstantin N. Yarygin Daria D. Namestnikova Kirill K. Sukhinich Ilya L. Gubskiy Alexander G. Majouga Irina V. Kholodenko
author_facet	Konstantin N. Yarygin Daria D. Namestnikova Kirill K. Sukhinich Ilya L. Gubskiy Alexander G. Majouga Irina V. Kholodenko
author_sort	Konstantin N. Yarygin
title	Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?
title_short	Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?
title_full	Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?
title_fullStr	Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?
title_full_unstemmed	Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?
title_sort	cell therapy of stroke: do the intra-arterially transplanted mesenchymal stem cells cross the blood–brain barrier?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b7afa2ef486749e995d051deb9667305
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Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood–Brain Barrier?

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