Identification of a novel snoRNA expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on RNA sequencing dataset

Since multiple studies have reported that small nucleolar RNAs (snoRNAs) can be serve as prognostic biomarkers for cancers, however, the prognostic values of snoRNAs in lung adenocarcinoma (LUAD) remain unclear. Therefore, the main work of this study is to identify the prognostic snoRNAs of LUAD and...

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Auteurs principaux:	Linbo Zhang, Mei Xin, Peng Wang
Format:	article
Langue:	EN
Publié:	AIMS Press 2021
Sujets:	rna sequencing snorna lung adenocarcinoma overall survival the cancer genome atlas Biotechnology TP248.13-248.65 Mathematics QA1-939
Accès en ligne:	https://doaj.org/article/b7b1f5d87d7f48fd9f6e60167dfb5ecb
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spelling	oai:doaj.org-article:b7b1f5d87d7f48fd9f6e60167dfb5ecb2021-11-23T02:50:25ZIdentification of a novel snoRNA expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on RNA sequencing dataset10.3934/mbe.20213891551-0018https://doaj.org/article/b7b1f5d87d7f48fd9f6e60167dfb5ecb2021-09-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021389?viewType=HTMLhttps://doaj.org/toc/1551-0018Since multiple studies have reported that small nucleolar RNAs (snoRNAs) can be serve as prognostic biomarkers for cancers, however, the prognostic values of snoRNAs in lung adenocarcinoma (LUAD) remain unclear. Therefore, the main work of this study is to identify the prognostic snoRNAs of LUAD and conduct a comprehensive analysis. The Cancer Genome Atlas LUAD cohort whole-genome RNA-sequencing dataset is included in this study, prognostic analysis and multiple bioinformatics approaches are used for comprehensive analysis and identification of prognostic snoRNAs. There were seven LUAD prognostic snoRNAs were screened in current study. We also constructed a novel expression signature containing five LUAD prognostic snoRNAs (snoU109, SNORA5A, SNORA70, SNORD104 and U3). Survival analysis of this expression signature reveals that LUAD patients with high risk score was significantly related to an unfavourable overall survival (adjusted P = 0.01, adjusted hazard ratio = 1.476, 95% confidence interval = 1.096-1.987). Functional analysis indicated that LUAD patients with different risk score phenotypes had significant differences in cell cycle, apoptosis, integrin, transforming growth factor beta, ErbB, nuclear factor kappa B, mitogen-activated protein kinase, phosphatidylinositol-3-kinase and toll like receptor signaling pathway. Immune microenvironment analysis also indicated that there were significant differences in immune microenvironment scores among LUAD patients with different risk score. In conclusion, this study identified an novel expression signature containing five LUAD prognostic snoRNAs, which may be serve as an independent prognostic indicator for LUAD patients.Linbo ZhangMei Xin Peng Wang AIMS Pressarticlerna sequencingsnornalung adenocarcinomaoverall survivalthe cancer genome atlasBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 6, Pp 7837-7860 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rna sequencing snorna lung adenocarcinoma overall survival the cancer genome atlas Biotechnology TP248.13-248.65 Mathematics QA1-939
spellingShingle	rna sequencing snorna lung adenocarcinoma overall survival the cancer genome atlas Biotechnology TP248.13-248.65 Mathematics QA1-939 Linbo Zhang Mei Xin Peng Wang Identification of a novel snoRNA expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on RNA sequencing dataset
description	Since multiple studies have reported that small nucleolar RNAs (snoRNAs) can be serve as prognostic biomarkers for cancers, however, the prognostic values of snoRNAs in lung adenocarcinoma (LUAD) remain unclear. Therefore, the main work of this study is to identify the prognostic snoRNAs of LUAD and conduct a comprehensive analysis. The Cancer Genome Atlas LUAD cohort whole-genome RNA-sequencing dataset is included in this study, prognostic analysis and multiple bioinformatics approaches are used for comprehensive analysis and identification of prognostic snoRNAs. There were seven LUAD prognostic snoRNAs were screened in current study. We also constructed a novel expression signature containing five LUAD prognostic snoRNAs (snoU109, SNORA5A, SNORA70, SNORD104 and U3). Survival analysis of this expression signature reveals that LUAD patients with high risk score was significantly related to an unfavourable overall survival (adjusted P = 0.01, adjusted hazard ratio = 1.476, 95% confidence interval = 1.096-1.987). Functional analysis indicated that LUAD patients with different risk score phenotypes had significant differences in cell cycle, apoptosis, integrin, transforming growth factor beta, ErbB, nuclear factor kappa B, mitogen-activated protein kinase, phosphatidylinositol-3-kinase and toll like receptor signaling pathway. Immune microenvironment analysis also indicated that there were significant differences in immune microenvironment scores among LUAD patients with different risk score. In conclusion, this study identified an novel expression signature containing five LUAD prognostic snoRNAs, which may be serve as an independent prognostic indicator for LUAD patients.
format	article
author	Linbo Zhang Mei Xin Peng Wang
author_facet	Linbo Zhang Mei Xin Peng Wang
author_sort	Linbo Zhang
title	Identification of a novel snoRNA expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on RNA sequencing dataset
title_short	Identification of a novel snoRNA expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on RNA sequencing dataset
title_full	Identification of a novel snoRNA expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on RNA sequencing dataset
title_fullStr	Identification of a novel snoRNA expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on RNA sequencing dataset
title_full_unstemmed	Identification of a novel snoRNA expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on RNA sequencing dataset
title_sort	identification of a novel snorna expression signature associated with overall survival in patients with lung adenocarcinoma: a comprehensive analysis based on rna sequencing dataset
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/b7b1f5d87d7f48fd9f6e60167dfb5ecb
work_keys_str_mv	AT linbozhang identificationofanovelsnornaexpressionsignatureassociatedwithoverallsurvivalinpatientswithlungadenocarcinomaacomprehensiveanalysisbasedonrnasequencingdataset AT meixin identificationofanovelsnornaexpressionsignatureassociatedwithoverallsurvivalinpatientswithlungadenocarcinomaacomprehensiveanalysisbasedonrnasequencingdataset AT pengwang identificationofanovelsnornaexpressionsignatureassociatedwithoverallsurvivalinpatientswithlungadenocarcinomaacomprehensiveanalysisbasedonrnasequencingdataset
_version_	1718417397500608512

Identification of a novel snoRNA expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on RNA sequencing dataset

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