Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery

Jae-Young Lee,1 Jung Sun Kim,2 Hyun-Jong Cho,3 Dae-Duk Kim1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea; 2Division of Health Sciences, Dongseo University, Busan, Republic of Korea; 3College of Pharmacy, Kangwon Nationa...

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Autores principales:	Lee JY, Kim JS, Cho HJ, Kim DD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b7b5f693c6c044129cd1f95ef0453aeb
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spelling	oai:doaj.org-article:b7b5f693c6c044129cd1f95ef0453aeb2021-12-02T00:10:20ZPoly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery1178-2013https://doaj.org/article/b7b5f693c6c044129cd1f95ef0453aeb2014-06-01T00:00:00Zhttp://www.dovepress.com/polystyrene-b-polydl-lactide-copolymer-based-nanoparticles-for-antican-a17091https://doaj.org/toc/1178-2013 Jae-Young Lee,1 Jung Sun Kim,2 Hyun-Jong Cho,3 Dae-Duk Kim1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea; 2Division of Health Sciences, Dongseo University, Busan, Republic of Korea; 3College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea Abstract: Poly(styrene)-b-poly(DL-lactide) (PS-PDLLA) copolymer-based nanoparticles (NPs) of a narrow size distribution, negative zeta potential, and spherical shape were fabricated for the delivery of docetaxel (DCT). The particle size was consistently maintained in serum for 24 hours and a sustained drug release pattern was observed for 10 days in the tested formulations. The cytotoxicity of the developed blank NPs was negligible in prostate cancer (PC-3) cells. Cellular uptake and distribution of the constructed NPs containing a hydrophobic fluorescent dye was monitored by confocal laser scanning microscopy (CLSM) for 24 hours. Anti-tumor efficacy of the PS-PDLLA/DCT NPs in PC-3 cells was significantly more potent than that of the group treated with commercially available DCT, Taxotere® (P<0.05). Blood biochemistry tests showed that no serious toxicity was observed with the blank NPs in the liver and kidney. In a pharmacokinetic study of DCT in rats, in vivo clearance of PS-PDLLA/DCT NPs decreased while the half-life in blood increased compared to the Taxotere-treated group (P<0.05). The PS-PDLLA NPs are expected to be a biocompatible and efficient nano-delivery system for anticancer drugs. Keywords: docetaxel, prolonged blood circulation, prostate cancerLee JYKim JSCho HJKim DDDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2803-2813 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lee JY Kim JS Cho HJ Kim DD Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery
description	Jae-Young Lee,1 Jung Sun Kim,2 Hyun-Jong Cho,3 Dae-Duk Kim1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea; 2Division of Health Sciences, Dongseo University, Busan, Republic of Korea; 3College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea Abstract: Poly(styrene)-b-poly(DL-lactide) (PS-PDLLA) copolymer-based nanoparticles (NPs) of a narrow size distribution, negative zeta potential, and spherical shape were fabricated for the delivery of docetaxel (DCT). The particle size was consistently maintained in serum for 24 hours and a sustained drug release pattern was observed for 10 days in the tested formulations. The cytotoxicity of the developed blank NPs was negligible in prostate cancer (PC-3) cells. Cellular uptake and distribution of the constructed NPs containing a hydrophobic fluorescent dye was monitored by confocal laser scanning microscopy (CLSM) for 24 hours. Anti-tumor efficacy of the PS-PDLLA/DCT NPs in PC-3 cells was significantly more potent than that of the group treated with commercially available DCT, Taxotere® (P<0.05). Blood biochemistry tests showed that no serious toxicity was observed with the blank NPs in the liver and kidney. In a pharmacokinetic study of DCT in rats, in vivo clearance of PS-PDLLA/DCT NPs decreased while the half-life in blood increased compared to the Taxotere-treated group (P<0.05). The PS-PDLLA NPs are expected to be a biocompatible and efficient nano-delivery system for anticancer drugs. Keywords: docetaxel, prolonged blood circulation, prostate cancer
format	article
author	Lee JY Kim JS Cho HJ Kim DD
author_facet	Lee JY Kim JS Cho HJ Kim DD
author_sort	Lee JY
title	Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery
title_short	Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery
title_full	Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery
title_fullStr	Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery
title_full_unstemmed	Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery
title_sort	poly(styrene)-b-poly(dl-lactide) copolymer-based nanoparticles for anticancer drug delivery
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b7b5f693c6c044129cd1f95ef0453aeb
work_keys_str_mv	AT leejy polystyrenebpolydllactidecopolymerbasednanoparticlesforanticancerdrugdelivery AT kimjs polystyrenebpolydllactidecopolymerbasednanoparticlesforanticancerdrugdelivery AT chohj polystyrenebpolydllactidecopolymerbasednanoparticlesforanticancerdrugdelivery AT kimdd polystyrenebpolydllactidecopolymerbasednanoparticlesforanticancerdrugdelivery
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Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for anticancer drug delivery

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