Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents

Abstract Little is known regarding the effects of environmental lead exposure on cardiovascular risk factors in the adolescent population. We studied 11,662 subjects included in the National Health and Nutrition Examination Survey (NHANES) 1999–2012. Blood lead levels were analysed for their associa...

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Autores principales:	Cheng Xu, Yaqin Shu, Zhi Fu, Yuanli Hu, Xuming Mo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7ba5e2749694a578b261c663088b3f4
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spelling	oai:doaj.org-article:b7ba5e2749694a578b261c663088b3f42021-12-02T16:08:23ZAssociations between lead concentrations and cardiovascular risk factors in U.S. adolescents10.1038/s41598-017-09701-42045-2322https://doaj.org/article/b7ba5e2749694a578b261c663088b3f42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09701-4https://doaj.org/toc/2045-2322Abstract Little is known regarding the effects of environmental lead exposure on cardiovascular risk factors in the adolescent population. We studied 11,662 subjects included in the National Health and Nutrition Examination Survey (NHANES) 1999–2012. Blood lead levels were analysed for their association with cardiovascular risk factors (CVRF). Regression coefficients (Beta) and 95% confidence intervals (CIs) of blood lead in association with CVRF (e.g., total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, fasting glucose, glycohemoglobin, fasting insulin, and blood pressure) were estimated using multivariate and generalized linear regression after adjusting for age, gender, ethnicity, serum cotinine, body mass index (BMI), physical activity, and household income. We identified a strong positive association between blood lead (coefficient = 0.022, 95% CI 0.003, 0.041; P = 0.022) and LDL-cholesterol in adolescents (age 12–19 years). However, no associations with other CVRFs were found in the overall population. In the generalized linear models, participants with the highest lead levels demonstrated a 1.87% (95% CI 0.73%, 3.02%) greater increase in serum LDL-cholesterol (p for trend = 0.031) when compared to participants with the lowest lead levels. These results provide epidemiological evidence that low levels of blood lead are positively associated with LDL-cholesterol in the adolescent population.Cheng XuYaqin ShuZhi FuYuanli HuXuming MoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cheng Xu Yaqin Shu Zhi Fu Yuanli Hu Xuming Mo Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents
description	Abstract Little is known regarding the effects of environmental lead exposure on cardiovascular risk factors in the adolescent population. We studied 11,662 subjects included in the National Health and Nutrition Examination Survey (NHANES) 1999–2012. Blood lead levels were analysed for their association with cardiovascular risk factors (CVRF). Regression coefficients (Beta) and 95% confidence intervals (CIs) of blood lead in association with CVRF (e.g., total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, fasting glucose, glycohemoglobin, fasting insulin, and blood pressure) were estimated using multivariate and generalized linear regression after adjusting for age, gender, ethnicity, serum cotinine, body mass index (BMI), physical activity, and household income. We identified a strong positive association between blood lead (coefficient = 0.022, 95% CI 0.003, 0.041; P = 0.022) and LDL-cholesterol in adolescents (age 12–19 years). However, no associations with other CVRFs were found in the overall population. In the generalized linear models, participants with the highest lead levels demonstrated a 1.87% (95% CI 0.73%, 3.02%) greater increase in serum LDL-cholesterol (p for trend = 0.031) when compared to participants with the lowest lead levels. These results provide epidemiological evidence that low levels of blood lead are positively associated with LDL-cholesterol in the adolescent population.
format	article
author	Cheng Xu Yaqin Shu Zhi Fu Yuanli Hu Xuming Mo
author_facet	Cheng Xu Yaqin Shu Zhi Fu Yuanli Hu Xuming Mo
author_sort	Cheng Xu
title	Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents
title_short	Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents
title_full	Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents
title_fullStr	Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents
title_full_unstemmed	Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents
title_sort	associations between lead concentrations and cardiovascular risk factors in u.s. adolescents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b7ba5e2749694a578b261c663088b3f4
work_keys_str_mv	AT chengxu associationsbetweenleadconcentrationsandcardiovascularriskfactorsinusadolescents AT yaqinshu associationsbetweenleadconcentrationsandcardiovascularriskfactorsinusadolescents AT zhifu associationsbetweenleadconcentrationsandcardiovascularriskfactorsinusadolescents AT yuanlihu associationsbetweenleadconcentrationsandcardiovascularriskfactorsinusadolescents AT xumingmo associationsbetweenleadconcentrationsandcardiovascularriskfactorsinusadolescents
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Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents

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