Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors
Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder.
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2019
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oai:doaj.org-article:b7ca995a09f14264a865413198bdb8892021-12-02T15:35:08ZAttenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors10.1038/s41467-019-11876-52041-1723https://doaj.org/article/b7ca995a09f14264a865413198bdb8892019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11876-5https://doaj.org/toc/2041-1723Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder.Nataliya GorinskiMonika BijataSonal PrasadAlexander WirthDalia Abdel GalilAndre ZeugDaria BazovkinaElena KondaurovaElizabeth KulikovaTatiana IlchibaevaMonika Zareba-KoziolFrancesco PapaleoDiego ScheggiaGaga KochlamazashviliAlexander DityatevIan SmythAdam KrzystyniakJakub WlodarczykDiethelm W. RichterTatyana StrekalovaStephan SigristClaudia BangLisa HobußJan FiedlerThomas ThumVladimir S. NaumenkoGhanshyam PandeyEvgeni PonimaskinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Nataliya Gorinski Monika Bijata Sonal Prasad Alexander Wirth Dalia Abdel Galil Andre Zeug Daria Bazovkina Elena Kondaurova Elizabeth Kulikova Tatiana Ilchibaeva Monika Zareba-Koziol Francesco Papaleo Diego Scheggia Gaga Kochlamazashvili Alexander Dityatev Ian Smyth Adam Krzystyniak Jakub Wlodarczyk Diethelm W. Richter Tatyana Strekalova Stephan Sigrist Claudia Bang Lisa Hobuß Jan Fiedler Thomas Thum Vladimir S. Naumenko Ghanshyam Pandey Evgeni Ponimaskin Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
| description |
Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder. |
| format |
article |
| author |
Nataliya Gorinski Monika Bijata Sonal Prasad Alexander Wirth Dalia Abdel Galil Andre Zeug Daria Bazovkina Elena Kondaurova Elizabeth Kulikova Tatiana Ilchibaeva Monika Zareba-Koziol Francesco Papaleo Diego Scheggia Gaga Kochlamazashvili Alexander Dityatev Ian Smyth Adam Krzystyniak Jakub Wlodarczyk Diethelm W. Richter Tatyana Strekalova Stephan Sigrist Claudia Bang Lisa Hobuß Jan Fiedler Thomas Thum Vladimir S. Naumenko Ghanshyam Pandey Evgeni Ponimaskin |
| author_facet |
Nataliya Gorinski Monika Bijata Sonal Prasad Alexander Wirth Dalia Abdel Galil Andre Zeug Daria Bazovkina Elena Kondaurova Elizabeth Kulikova Tatiana Ilchibaeva Monika Zareba-Koziol Francesco Papaleo Diego Scheggia Gaga Kochlamazashvili Alexander Dityatev Ian Smyth Adam Krzystyniak Jakub Wlodarczyk Diethelm W. Richter Tatyana Strekalova Stephan Sigrist Claudia Bang Lisa Hobuß Jan Fiedler Thomas Thum Vladimir S. Naumenko Ghanshyam Pandey Evgeni Ponimaskin |
| author_sort |
Nataliya Gorinski |
| title |
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
| title_short |
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
| title_full |
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
| title_fullStr |
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
| title_full_unstemmed |
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors |
| title_sort |
attenuated palmitoylation of serotonin receptor 5-ht1a affects receptor function and contributes to depression-like behaviors |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/b7ca995a09f14264a865413198bdb889 |
| work_keys_str_mv |
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