The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

Metabolites have been reported not only to support the highly-demanding energetic needs of cancer cells but also as signalling regulators. Here, the authors show that the activity of the folate cycle enzyme MTHFD2 stimulates PD-L1 expression impairing T cell-mediated cytotoxicity and promoting tumou...

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Autores principales:	Man Shang, Huijie Yang, Ran Yang, Tao Chen, Yuan Fu, Yeyi Li, Xianlong Fang, Kangjian Zhang, Jianju Zhang, Hui Li, Xueping Cao, Jinfa Gu, Jianwen Xiao, Qi Zhang, Xinyuan Liu, Qiujing Yu, Ting Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7caa2a1cda04d89abb70680d3147f73
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spelling	oai:doaj.org-article:b7caa2a1cda04d89abb70680d3147f732021-12-02T14:25:31ZThe folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation10.1038/s41467-021-22173-52041-1723https://doaj.org/article/b7caa2a1cda04d89abb70680d3147f732021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22173-5https://doaj.org/toc/2041-1723Metabolites have been reported not only to support the highly-demanding energetic needs of cancer cells but also as signalling regulators. Here, the authors show that the activity of the folate cycle enzyme MTHFD2 stimulates PD-L1 expression impairing T cell-mediated cytotoxicity and promoting tumourigenesis.Man ShangHuijie YangRan YangTao ChenYuan FuYeyi LiXianlong FangKangjian ZhangJianju ZhangHui LiXueping CaoJinfa GuJianwen XiaoQi ZhangXinyuan LiuQiujing YuTing WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Man Shang Huijie Yang Ran Yang Tao Chen Yuan Fu Yeyi Li Xianlong Fang Kangjian Zhang Jianju Zhang Hui Li Xueping Cao Jinfa Gu Jianwen Xiao Qi Zhang Xinyuan Liu Qiujing Yu Ting Wang The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
description	Metabolites have been reported not only to support the highly-demanding energetic needs of cancer cells but also as signalling regulators. Here, the authors show that the activity of the folate cycle enzyme MTHFD2 stimulates PD-L1 expression impairing T cell-mediated cytotoxicity and promoting tumourigenesis.
format	article
author	Man Shang Huijie Yang Ran Yang Tao Chen Yuan Fu Yeyi Li Xianlong Fang Kangjian Zhang Jianju Zhang Hui Li Xueping Cao Jinfa Gu Jianwen Xiao Qi Zhang Xinyuan Liu Qiujing Yu Ting Wang
author_facet	Man Shang Huijie Yang Ran Yang Tao Chen Yuan Fu Yeyi Li Xianlong Fang Kangjian Zhang Jianju Zhang Hui Li Xueping Cao Jinfa Gu Jianwen Xiao Qi Zhang Xinyuan Liu Qiujing Yu Ting Wang
author_sort	Man Shang
title	The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
title_short	The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
title_full	The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
title_fullStr	The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
title_full_unstemmed	The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
title_sort	folate cycle enzyme mthfd2 induces cancer immune evasion through pd-l1 up-regulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b7caa2a1cda04d89abb70680d3147f73
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The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

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