Implication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure

Alphaviruses are enveloped RNA viruses that contain several human pathogens. Here, the authors use block-based reconstruction method and provide a 3.5 Å cryo-EM structure of sindbis virus that identifies a conserved hydrophobic pocket near the viral membrane that is stabilized by an unknown pocket f...

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Autores principales:	Lihong Chen, Ming Wang, Dongjie Zhu, Zhenzhao Sun, Jun Ma, Jinglin Wang, Lingfei Kong, Shida Wang, Zaisi Liu, Lili Wei, Yuwen He, Jingfei Wang, Xinzheng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7ce35978c4040f9bd16bfeabee93ecf
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spelling	oai:doaj.org-article:b7ce35978c4040f9bd16bfeabee93ecf2021-12-02T15:34:41ZImplication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure10.1038/s41467-018-07704-x2041-1723https://doaj.org/article/b7ce35978c4040f9bd16bfeabee93ecf2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07704-xhttps://doaj.org/toc/2041-1723Alphaviruses are enveloped RNA viruses that contain several human pathogens. Here, the authors use block-based reconstruction method and provide a 3.5 Å cryo-EM structure of sindbis virus that identifies a conserved hydrophobic pocket near the viral membrane that is stabilized by an unknown pocket factor.Lihong ChenMing WangDongjie ZhuZhenzhao SunJun MaJinglin WangLingfei KongShida WangZaisi LiuLili WeiYuwen HeJingfei WangXinzheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lihong Chen Ming Wang Dongjie Zhu Zhenzhao Sun Jun Ma Jinglin Wang Lingfei Kong Shida Wang Zaisi Liu Lili Wei Yuwen He Jingfei Wang Xinzheng Zhang Implication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure
description	Alphaviruses are enveloped RNA viruses that contain several human pathogens. Here, the authors use block-based reconstruction method and provide a 3.5 Å cryo-EM structure of sindbis virus that identifies a conserved hydrophobic pocket near the viral membrane that is stabilized by an unknown pocket factor.
format	article
author	Lihong Chen Ming Wang Dongjie Zhu Zhenzhao Sun Jun Ma Jinglin Wang Lingfei Kong Shida Wang Zaisi Liu Lili Wei Yuwen He Jingfei Wang Xinzheng Zhang
author_facet	Lihong Chen Ming Wang Dongjie Zhu Zhenzhao Sun Jun Ma Jinglin Wang Lingfei Kong Shida Wang Zaisi Liu Lili Wei Yuwen He Jingfei Wang Xinzheng Zhang
author_sort	Lihong Chen
title	Implication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure
title_short	Implication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure
title_full	Implication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure
title_fullStr	Implication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure
title_full_unstemmed	Implication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure
title_sort	implication for alphavirus host-cell entry and assembly indicated by a 3.5å resolution cryo-em structure
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b7ce35978c4040f9bd16bfeabee93ecf
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_version_	1718386801582800896

Implication for alphavirus host-cell entry and assembly indicated by a 3.5Å resolution cryo-EM structure

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