Trans-tail regulation-mediated suppression of cryptic transcription

Cell biology: Interaction of DNA-winding proteins ensures correct gene expression Crosstalk between different DNA-winding proteins, or histones, is a mechanism of molecular fidelity that helps prevent the initiation of aberrant gene expression, which may contribute to cancer and neurodegenerative di...

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Autores principales:	Jungmin Choi, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/b7cf57632e8a48a381b88dd44b26e808
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spelling	oai:doaj.org-article:b7cf57632e8a48a381b88dd44b26e8082021-12-05T12:24:25ZTrans-tail regulation-mediated suppression of cryptic transcription10.1038/s12276-021-00711-x1226-36132092-6413https://doaj.org/article/b7cf57632e8a48a381b88dd44b26e8082021-11-01T00:00:00Zhttps://doi.org/10.1038/s12276-021-00711-xhttps://doaj.org/toc/1226-3613https://doaj.org/toc/2092-6413Cell biology: Interaction of DNA-winding proteins ensures correct gene expression Crosstalk between different DNA-winding proteins, or histones, is a mechanism of molecular fidelity that helps prevent the initiation of aberrant gene expression, which may contribute to cancer and neurodegenerative disease. A team from South Korea, led by Jungmin Choi from the Korea University College of Medicine in Seoul and Hong-Yeoul Ryu from Kyungpook National University in Daegu, review the ways in which different histone proteins chemically modify parts of each other’s structure to regulate their functions. These modifications affect how histones interact with DNA, which in turn alters the dynamics of other factors implicated in gene expression. The correct interaction of histones is necessary to prevent the gene expression machinery from starting RNA synthesis from the wrong sites. Accurate control of these mechanisms is essential for cellular wellbeingJungmin ChoiZae Young RyooDong-Hyung ChoHyun-Shik LeeHong-Yeoul RyuNature Publishing GrouparticleMedicineRBiochemistryQD415-436ENExperimental and Molecular Medicine, Vol 53, Iss 11, Pp 1683-1688 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biochemistry QD415-436
spellingShingle	Medicine R Biochemistry QD415-436 Jungmin Choi Zae Young Ryoo Dong-Hyung Cho Hyun-Shik Lee Hong-Yeoul Ryu Trans-tail regulation-mediated suppression of cryptic transcription
description	Cell biology: Interaction of DNA-winding proteins ensures correct gene expression Crosstalk between different DNA-winding proteins, or histones, is a mechanism of molecular fidelity that helps prevent the initiation of aberrant gene expression, which may contribute to cancer and neurodegenerative disease. A team from South Korea, led by Jungmin Choi from the Korea University College of Medicine in Seoul and Hong-Yeoul Ryu from Kyungpook National University in Daegu, review the ways in which different histone proteins chemically modify parts of each other’s structure to regulate their functions. These modifications affect how histones interact with DNA, which in turn alters the dynamics of other factors implicated in gene expression. The correct interaction of histones is necessary to prevent the gene expression machinery from starting RNA synthesis from the wrong sites. Accurate control of these mechanisms is essential for cellular wellbeing
format	article
author	Jungmin Choi Zae Young Ryoo Dong-Hyung Cho Hyun-Shik Lee Hong-Yeoul Ryu
author_facet	Jungmin Choi Zae Young Ryoo Dong-Hyung Cho Hyun-Shik Lee Hong-Yeoul Ryu
author_sort	Jungmin Choi
title	Trans-tail regulation-mediated suppression of cryptic transcription
title_short	Trans-tail regulation-mediated suppression of cryptic transcription
title_full	Trans-tail regulation-mediated suppression of cryptic transcription
title_fullStr	Trans-tail regulation-mediated suppression of cryptic transcription
title_full_unstemmed	Trans-tail regulation-mediated suppression of cryptic transcription
title_sort	trans-tail regulation-mediated suppression of cryptic transcription
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/b7cf57632e8a48a381b88dd44b26e808
work_keys_str_mv	AT jungminchoi transtailregulationmediatedsuppressionofcryptictranscription AT zaeyoungryoo transtailregulationmediatedsuppressionofcryptictranscription AT donghyungcho transtailregulationmediatedsuppressionofcryptictranscription AT hyunshiklee transtailregulationmediatedsuppressionofcryptictranscription AT hongyeoulryu transtailregulationmediatedsuppressionofcryptictranscription
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Trans-tail regulation-mediated suppression of cryptic transcription

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