Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2

Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2

Kanako Shimizu et al. identify HLA-A24 high-binding epitopes in the SARS-CoV-2 spike region and investigate their cross-reactivity with CD8+ T cell receptors. These results provide further insight into CD8+ T cell cross-reactivity toward SARS-CoV-2 and may be useful in future strategies for vaccine...

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Autores principales: Kanako Shimizu, Tomonori Iyoda, An Sanpei, Hiroshi Nakazato, Masahiro Okada, Shogo Ueda, Miyuki Kato-Murayama, Kazutaka Murayama, Mikako Shirouzu, Naoko Harada, Michihiro Hidaka, Shin-ichiro Fujii
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/b7cfecf00c01417f9f7847303e27b7d3
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Sumario:Kanako Shimizu et al. identify HLA-A24 high-binding epitopes in the SARS-CoV-2 spike region and investigate their cross-reactivity with CD8+ T cell receptors. These results provide further insight into CD8+ T cell cross-reactivity toward SARS-CoV-2 and may be useful in future strategies for vaccine development.

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