Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2

Kanako Shimizu et al. identify HLA-A24 high-binding epitopes in the SARS-CoV-2 spike region and investigate their cross-reactivity with CD8+ T cell receptors. These results provide further insight into CD8+ T cell cross-reactivity toward SARS-CoV-2 and may be useful in future strategies for vaccine...

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Autores principales:	Kanako Shimizu, Tomonori Iyoda, An Sanpei, Hiroshi Nakazato, Masahiro Okada, Shogo Ueda, Miyuki Kato-Murayama, Kazutaka Murayama, Mikako Shirouzu, Naoko Harada, Michihiro Hidaka, Shin-ichiro Fujii
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b7cfecf00c01417f9f7847303e27b7d3
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spelling	oai:doaj.org-article:b7cfecf00c01417f9f7847303e27b7d32021-12-05T12:08:20ZIdentification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-210.1038/s42003-021-02885-62399-3642https://doaj.org/article/b7cfecf00c01417f9f7847303e27b7d32021-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02885-6https://doaj.org/toc/2399-3642Kanako Shimizu et al. identify HLA-A24 high-binding epitopes in the SARS-CoV-2 spike region and investigate their cross-reactivity with CD8+ T cell receptors. These results provide further insight into CD8+ T cell cross-reactivity toward SARS-CoV-2 and may be useful in future strategies for vaccine development.Kanako ShimizuTomonori IyodaAn SanpeiHiroshi NakazatoMasahiro OkadaShogo UedaMiyuki Kato-MurayamaKazutaka MurayamaMikako ShirouzuNaoko HaradaMichihiro HidakaShin-ichiro FujiiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kanako Shimizu Tomonori Iyoda An Sanpei Hiroshi Nakazato Masahiro Okada Shogo Ueda Miyuki Kato-Murayama Kazutaka Murayama Mikako Shirouzu Naoko Harada Michihiro Hidaka Shin-ichiro Fujii Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2
description	Kanako Shimizu et al. identify HLA-A24 high-binding epitopes in the SARS-CoV-2 spike region and investigate their cross-reactivity with CD8+ T cell receptors. These results provide further insight into CD8+ T cell cross-reactivity toward SARS-CoV-2 and may be useful in future strategies for vaccine development.
format	article
author	Kanako Shimizu Tomonori Iyoda An Sanpei Hiroshi Nakazato Masahiro Okada Shogo Ueda Miyuki Kato-Murayama Kazutaka Murayama Mikako Shirouzu Naoko Harada Michihiro Hidaka Shin-ichiro Fujii
author_facet	Kanako Shimizu Tomonori Iyoda An Sanpei Hiroshi Nakazato Masahiro Okada Shogo Ueda Miyuki Kato-Murayama Kazutaka Murayama Mikako Shirouzu Naoko Harada Michihiro Hidaka Shin-ichiro Fujii
author_sort	Kanako Shimizu
title	Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2
title_short	Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2
title_full	Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2
title_fullStr	Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2
title_full_unstemmed	Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2
title_sort	identification of tcr repertoires in functionally competent cytotoxic t cells cross-reactive to sars-cov-2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b7cfecf00c01417f9f7847303e27b7d3
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Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2

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