Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.

Humans are extraordinarily social, and social isolation has profound effects on our behavior, ranging from increased social motivation following short periods of social isolation to increased anti-social behaviors following long-term social isolation. Mice are frequently used as a model to understan...

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Autores principales:	Xin Zhao, Patryk Ziobro, Nicole M Pranic, Samantha Chu, Samantha Rabinovich, William Chan, Jennifer Zhao, Caroline Kornbrek, Zichen He, Katherine A Tschida
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7d03d295d5c42628546b58cf830dbc9
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spelling	oai:doaj.org-article:b7d03d295d5c42628546b58cf830dbc92021-12-02T20:08:43ZSex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.1932-620310.1371/journal.pone.0255640https://doaj.org/article/b7d03d295d5c42628546b58cf830dbc92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255640https://doaj.org/toc/1932-6203Humans are extraordinarily social, and social isolation has profound effects on our behavior, ranging from increased social motivation following short periods of social isolation to increased anti-social behaviors following long-term social isolation. Mice are frequently used as a model to understand how social isolation impacts the brain and behavior. While the effects of chronic social isolation on mouse social behavior have been well studied, much less is known about how acute isolation impacts mouse social behavior and whether these effects vary according to the sex of the mouse and the behavioral context of the social encounter. To address these questions, we characterized the effects of acute (3-day) social isolation on the vocal and non-vocal social behaviors of male and female mice during same-sex and opposite-sex social interactions. Our experiments uncovered pronounced effects of acute isolation on social interactions between female mice, while revealing more subtle effects on the social behaviors of male mice during same-sex and opposite-sex interactions. Our findings advance the study of same-sex interactions between female mice as an attractive paradigm to investigate neural mechanisms through which acute isolation enhances social motivation and promotes social behavior.Xin ZhaoPatryk ZiobroNicole M PranicSamantha ChuSamantha RabinovichWilliam ChanJennifer ZhaoCaroline KornbrekZichen HeKatherine A TschidaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0255640 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Zhao Patryk Ziobro Nicole M Pranic Samantha Chu Samantha Rabinovich William Chan Jennifer Zhao Caroline Kornbrek Zichen He Katherine A Tschida Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.
description	Humans are extraordinarily social, and social isolation has profound effects on our behavior, ranging from increased social motivation following short periods of social isolation to increased anti-social behaviors following long-term social isolation. Mice are frequently used as a model to understand how social isolation impacts the brain and behavior. While the effects of chronic social isolation on mouse social behavior have been well studied, much less is known about how acute isolation impacts mouse social behavior and whether these effects vary according to the sex of the mouse and the behavioral context of the social encounter. To address these questions, we characterized the effects of acute (3-day) social isolation on the vocal and non-vocal social behaviors of male and female mice during same-sex and opposite-sex social interactions. Our experiments uncovered pronounced effects of acute isolation on social interactions between female mice, while revealing more subtle effects on the social behaviors of male mice during same-sex and opposite-sex interactions. Our findings advance the study of same-sex interactions between female mice as an attractive paradigm to investigate neural mechanisms through which acute isolation enhances social motivation and promotes social behavior.
format	article
author	Xin Zhao Patryk Ziobro Nicole M Pranic Samantha Chu Samantha Rabinovich William Chan Jennifer Zhao Caroline Kornbrek Zichen He Katherine A Tschida
author_facet	Xin Zhao Patryk Ziobro Nicole M Pranic Samantha Chu Samantha Rabinovich William Chan Jennifer Zhao Caroline Kornbrek Zichen He Katherine A Tschida
author_sort	Xin Zhao
title	Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.
title_short	Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.
title_full	Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.
title_fullStr	Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.
title_full_unstemmed	Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.
title_sort	sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b7d03d295d5c42628546b58cf830dbc9
work_keys_str_mv	AT xinzhao sexandcontextdependenteffectsofacuteisolationonvocalandnonvocalsocialbehaviorsinmice AT patrykziobro sexandcontextdependenteffectsofacuteisolationonvocalandnonvocalsocialbehaviorsinmice AT nicolempranic sexandcontextdependenteffectsofacuteisolationonvocalandnonvocalsocialbehaviorsinmice AT samanthachu sexandcontextdependenteffectsofacuteisolationonvocalandnonvocalsocialbehaviorsinmice AT samantharabinovich sexandcontextdependenteffectsofacuteisolationonvocalandnonvocalsocialbehaviorsinmice AT williamchan sexandcontextdependenteffectsofacuteisolationonvocalandnonvocalsocialbehaviorsinmice AT jenniferzhao sexandcontextdependenteffectsofacuteisolationonvocalandnonvocalsocialbehaviorsinmice AT carolinekornbrek sexandcontextdependenteffectsofacuteisolationonvocalandnonvocalsocialbehaviorsinmice AT zichenhe sexandcontextdependenteffectsofacuteisolationonvocalandnonvocalsocialbehaviorsinmice AT katherineatschida sexandcontextdependenteffectsofacuteisolationonvocalandnonvocalsocialbehaviorsinmice
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Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.

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