Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson’s Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment

BackgroundNeuroinflammation and mitochondrial impairment play important roles in the neuropathogenesis of Parkinson’s disease (PD). The activation of NLRP3 inflammasome and the accumulation of α-synuclein (α-Syn) are strictly correlated to neuroinflammation. Therefore, the regulation of NLRP3 inflam...

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Autores principales:	Rongfang Que, Jialing Zheng, Zihan Chang, Wenjie Zhang, Hualing Li, Zhenchao Xie, Zifeng Huang, Hai-Tao Wang, Jiangping Xu, Dana Jin, Wanlin Yang, Eng-King Tan, Qing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Parkinson’s disease dl-3-n-Butylphthalide NLRP3 inflammasome neuroinflammation α-Synuclein PARP1 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b7d5643e59ba4472b6f50778febfc8f8
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Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson’s Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment

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