Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification

The considerable development of carrier-free nanodrugs has been achieved due to their high drug-loading capability, simple preparation method, and offering “all-in-one” functional platform features. However, the native defects of carrier-free nanodrugs limit their delivery and release behavior throu...

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Autores principales:	Heng Mei, Shengsheng Cai, Dennis Huang, Huile Gao, Jun Cao, Bin He
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Carrier-free nanodrugs Drug delivery and release Intrinsic physicochemical properties External modification Therapeutic efficacy Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b7d73b4049954ea78e1ebb803ed5e4b8
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spelling	oai:doaj.org-article:b7d73b4049954ea78e1ebb803ed5e4b82021-11-04T04:36:24ZCarrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification2452-199X10.1016/j.bioactmat.2021.06.035https://doaj.org/article/b7d73b4049954ea78e1ebb803ed5e4b82022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003212https://doaj.org/toc/2452-199XThe considerable development of carrier-free nanodrugs has been achieved due to their high drug-loading capability, simple preparation method, and offering “all-in-one” functional platform features. However, the native defects of carrier-free nanodrugs limit their delivery and release behavior throughout the in vivo journey, which significantly compromise the therapeutic efficacy and hinder their further development in cancer treatment. In this review, we summarized and discussed the recent strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy, including optimizing the intrinsic physicochemical properties and external modification. Finally, the corresponding challenges that carrier-free nanodrugs faced are discussed and the future perspectives for its application are presented. We hope this review will provide constructive information for the rational design of more effective carrier-free nanodrugs to advance therapeutic treatment.Heng MeiShengsheng CaiDennis HuangHuile GaoJun CaoBin HeKeAi Communications Co., Ltd.articleCarrier-free nanodrugsDrug delivery and releaseIntrinsic physicochemical propertiesExternal modificationTherapeutic efficacyMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 220-240 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Carrier-free nanodrugs Drug delivery and release Intrinsic physicochemical properties External modification Therapeutic efficacy Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Carrier-free nanodrugs Drug delivery and release Intrinsic physicochemical properties External modification Therapeutic efficacy Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Heng Mei Shengsheng Cai Dennis Huang Huile Gao Jun Cao Bin He Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification
description	The considerable development of carrier-free nanodrugs has been achieved due to their high drug-loading capability, simple preparation method, and offering “all-in-one” functional platform features. However, the native defects of carrier-free nanodrugs limit their delivery and release behavior throughout the in vivo journey, which significantly compromise the therapeutic efficacy and hinder their further development in cancer treatment. In this review, we summarized and discussed the recent strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy, including optimizing the intrinsic physicochemical properties and external modification. Finally, the corresponding challenges that carrier-free nanodrugs faced are discussed and the future perspectives for its application are presented. We hope this review will provide constructive information for the rational design of more effective carrier-free nanodrugs to advance therapeutic treatment.
format	article
author	Heng Mei Shengsheng Cai Dennis Huang Huile Gao Jun Cao Bin He
author_facet	Heng Mei Shengsheng Cai Dennis Huang Huile Gao Jun Cao Bin He
author_sort	Heng Mei
title	Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification
title_short	Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification
title_full	Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification
title_fullStr	Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification
title_full_unstemmed	Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification
title_sort	carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: from intrinsic physicochemical properties to external modification
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/b7d73b4049954ea78e1ebb803ed5e4b8
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Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification

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