An examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake

Abstract The selection of cattle with enhanced feed efficiency is of importance with regard to reducing feed costs in the beef industry. Global transcriptome profiling was undertaken on liver and skeletal muscle biopsies from Simmental heifers and bulls divergent for residual feed intake (RFI), a wi...

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Autores principales:	Clare McKenna, Kate Keogh, Richard K. Porter, Sinead M. Waters, Paul Cormican, David A. Kenny
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7d84ec5cd544ca88f6ac7ba110a606f
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spelling	oai:doaj.org-article:b7d84ec5cd544ca88f6ac7ba110a606f2021-12-02T17:39:19ZAn examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake10.1038/s41598-021-87842-32045-2322https://doaj.org/article/b7d84ec5cd544ca88f6ac7ba110a606f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87842-3https://doaj.org/toc/2045-2322Abstract The selection of cattle with enhanced feed efficiency is of importance with regard to reducing feed costs in the beef industry. Global transcriptome profiling was undertaken on liver and skeletal muscle biopsies from Simmental heifers and bulls divergent for residual feed intake (RFI), a widely acknowledged feed efficiency phenotype, in order to identify genes that may be associated with this trait. We identified 5 genes (adj. p < 0.1) to be differentially expressed in skeletal muscle between high and low RFI heifers with all transcripts involved in oxidative phosphorylation and mitochondrial homeostasis. A total of 11 genes (adj. p < 0. 1) were differentially expressed in liver tissue between high and low RFI bulls with differentially expressed genes related to amino and nucleotide metabolism as well as endoplasmic reticulum protein processing. No genes were identified as differentially expressed in either heifer liver or bull muscle analyses. Results from this study show that the molecular control of RFI in young cattle is modified according to gender, which may be attributable to differences in physiological maturity between heifers and bulls of the same age. Despite this we have highlighted a number of genes that may hold potential as molecular biomarkers for RFI cattle.Clare McKennaKate KeoghRichard K. PorterSinead M. WatersPaul CormicanDavid A. KennyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clare McKenna Kate Keogh Richard K. Porter Sinead M. Waters Paul Cormican David A. Kenny An examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake
description	Abstract The selection of cattle with enhanced feed efficiency is of importance with regard to reducing feed costs in the beef industry. Global transcriptome profiling was undertaken on liver and skeletal muscle biopsies from Simmental heifers and bulls divergent for residual feed intake (RFI), a widely acknowledged feed efficiency phenotype, in order to identify genes that may be associated with this trait. We identified 5 genes (adj. p < 0.1) to be differentially expressed in skeletal muscle between high and low RFI heifers with all transcripts involved in oxidative phosphorylation and mitochondrial homeostasis. A total of 11 genes (adj. p < 0. 1) were differentially expressed in liver tissue between high and low RFI bulls with differentially expressed genes related to amino and nucleotide metabolism as well as endoplasmic reticulum protein processing. No genes were identified as differentially expressed in either heifer liver or bull muscle analyses. Results from this study show that the molecular control of RFI in young cattle is modified according to gender, which may be attributable to differences in physiological maturity between heifers and bulls of the same age. Despite this we have highlighted a number of genes that may hold potential as molecular biomarkers for RFI cattle.
format	article
author	Clare McKenna Kate Keogh Richard K. Porter Sinead M. Waters Paul Cormican David A. Kenny
author_facet	Clare McKenna Kate Keogh Richard K. Porter Sinead M. Waters Paul Cormican David A. Kenny
author_sort	Clare McKenna
title	An examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake
title_short	An examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake
title_full	An examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake
title_fullStr	An examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake
title_full_unstemmed	An examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake
title_sort	examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b7d84ec5cd544ca88f6ac7ba110a606f
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An examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake

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