NCLX prevents cell death during adrenergic activation of the brown adipose tissue

Brown adipose tissue activation of thermogenesis is accompanied by a sequence of events commonly associated with apoptosis, however they evade cell death. Assali et al. show that NCLX prevents mitochondrial calcium overload and apoptosis. Deletion of NCLX, converts a thermogenic signal into a death...

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Autores principales:	Essam A. Assali, Anthony E. Jones, Michaela Veliova, Rebeca Acín-Pérez, Mahmoud Taha, Nathanael Miller, Michaël Shum, Marcus F. Oliveira, Guy Las, Marc Liesa, Israel Sekler, Orian S. Shirihai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7d8f16459e24177b94890292b6533d2
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spelling	oai:doaj.org-article:b7d8f16459e24177b94890292b6533d22021-12-02T18:18:53ZNCLX prevents cell death during adrenergic activation of the brown adipose tissue10.1038/s41467-020-16572-32041-1723https://doaj.org/article/b7d8f16459e24177b94890292b6533d22020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16572-3https://doaj.org/toc/2041-1723Brown adipose tissue activation of thermogenesis is accompanied by a sequence of events commonly associated with apoptosis, however they evade cell death. Assali et al. show that NCLX prevents mitochondrial calcium overload and apoptosis. Deletion of NCLX, converts a thermogenic signal into a death pathway.Essam A. AssaliAnthony E. JonesMichaela VeliovaRebeca Acín-PérezMahmoud TahaNathanael MillerMichaël ShumMarcus F. OliveiraGuy LasMarc LiesaIsrael SeklerOrian S. ShirihaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Essam A. Assali Anthony E. Jones Michaela Veliova Rebeca Acín-Pérez Mahmoud Taha Nathanael Miller Michaël Shum Marcus F. Oliveira Guy Las Marc Liesa Israel Sekler Orian S. Shirihai NCLX prevents cell death during adrenergic activation of the brown adipose tissue
description	Brown adipose tissue activation of thermogenesis is accompanied by a sequence of events commonly associated with apoptosis, however they evade cell death. Assali et al. show that NCLX prevents mitochondrial calcium overload and apoptosis. Deletion of NCLX, converts a thermogenic signal into a death pathway.
format	article
author	Essam A. Assali Anthony E. Jones Michaela Veliova Rebeca Acín-Pérez Mahmoud Taha Nathanael Miller Michaël Shum Marcus F. Oliveira Guy Las Marc Liesa Israel Sekler Orian S. Shirihai
author_facet	Essam A. Assali Anthony E. Jones Michaela Veliova Rebeca Acín-Pérez Mahmoud Taha Nathanael Miller Michaël Shum Marcus F. Oliveira Guy Las Marc Liesa Israel Sekler Orian S. Shirihai
author_sort	Essam A. Assali
title	NCLX prevents cell death during adrenergic activation of the brown adipose tissue
title_short	NCLX prevents cell death during adrenergic activation of the brown adipose tissue
title_full	NCLX prevents cell death during adrenergic activation of the brown adipose tissue
title_fullStr	NCLX prevents cell death during adrenergic activation of the brown adipose tissue
title_full_unstemmed	NCLX prevents cell death during adrenergic activation of the brown adipose tissue
title_sort	nclx prevents cell death during adrenergic activation of the brown adipose tissue
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b7d8f16459e24177b94890292b6533d2
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NCLX prevents cell death during adrenergic activation of the brown adipose tissue

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