Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells

Evidence of how functional Bregs develop in vivo has been lacking. Here the authors show that proB cells exposed in vivoto CpG differentiate into distinct Breg subsets that inhibit autoimmunity by arresting T cells in the lymph nodes via CCL19 and by producing IL-10 at the site of immunopathology.

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Autores principales:	Sarantis Korniotis, Christophe Gras, Hélène Letscher, Ruddy Montandon, Jérôme Mégret, Stefanie Siegert, Sophie Ezine, Padraic G. Fallon, Sanjiv A. Luther, Simon Fillatreau, Flora Zavala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7d9504d2aed4006b464e2e920a9a15c
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spelling	oai:doaj.org-article:b7d9504d2aed4006b464e2e920a9a15c2021-12-02T15:34:10ZTreatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells10.1038/ncomms121342041-1723https://doaj.org/article/b7d9504d2aed4006b464e2e920a9a15c2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12134https://doaj.org/toc/2041-1723Evidence of how functional Bregs develop in vivo has been lacking. Here the authors show that proB cells exposed in vivoto CpG differentiate into distinct Breg subsets that inhibit autoimmunity by arresting T cells in the lymph nodes via CCL19 and by producing IL-10 at the site of immunopathology.Sarantis KorniotisChristophe GrasHélène LetscherRuddy MontandonJérôme MégretStefanie SiegertSophie EzinePadraic G. FallonSanjiv A. LutherSimon FillatreauFlora ZavalaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarantis Korniotis Christophe Gras Hélène Letscher Ruddy Montandon Jérôme Mégret Stefanie Siegert Sophie Ezine Padraic G. Fallon Sanjiv A. Luther Simon Fillatreau Flora Zavala Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells
description	Evidence of how functional Bregs develop in vivo has been lacking. Here the authors show that proB cells exposed in vivoto CpG differentiate into distinct Breg subsets that inhibit autoimmunity by arresting T cells in the lymph nodes via CCL19 and by producing IL-10 at the site of immunopathology.
format	article
author	Sarantis Korniotis Christophe Gras Hélène Letscher Ruddy Montandon Jérôme Mégret Stefanie Siegert Sophie Ezine Padraic G. Fallon Sanjiv A. Luther Simon Fillatreau Flora Zavala
author_facet	Sarantis Korniotis Christophe Gras Hélène Letscher Ruddy Montandon Jérôme Mégret Stefanie Siegert Sophie Ezine Padraic G. Fallon Sanjiv A. Luther Simon Fillatreau Flora Zavala
author_sort	Sarantis Korniotis
title	Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells
title_short	Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells
title_full	Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells
title_fullStr	Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells
title_full_unstemmed	Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells
title_sort	treatment of ongoing autoimmune encephalomyelitis with activated b-cell progenitors maturing into regulatory b cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b7d9504d2aed4006b464e2e920a9a15c
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Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells

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