β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with type 2 diabetes: A cross-sectional study

Type 2 diabetes mellitus (T2DM) is a strong risk tfactor for osteosarcopenia. The relationship between musculoskeletal index and β-cell function remains controversial. We aimed to describe the clinical characteristics of osteosarcopenia and to explore the association between osteosarcopenia and β-ce...

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Autores principales:	Liu Jidong, Yu Dongqing, Xu Mingyue, Feng Ruiying, Sun Yujing, Yin Xiaofei, Lai Hong, Wang Chuan, Liu Jinbo
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	β-cell function osteosarcopenia t2dm skeletal muscle mass index Medicine R
Acceso en línea:	https://doaj.org/article/b7da9cfd1e94415194d76da827998338
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spelling	oai:doaj.org-article:b7da9cfd1e94415194d76da8279983382021-12-05T14:10:55Zβ-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with type 2 diabetes: A cross-sectional study2391-546310.1515/med-2021-0376https://doaj.org/article/b7da9cfd1e94415194d76da8279983382021-10-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0376https://doaj.org/toc/2391-5463Type 2 diabetes mellitus (T2DM) is a strong risk tfactor for osteosarcopenia. The relationship between musculoskeletal index and β-cell function remains controversial. We aimed to describe the clinical characteristics of osteosarcopenia and to explore the association between osteosarcopenia and β-cell function, as well as insulin resistance in patients with T2DM. A total of 150 middle-aged and older nonobese patients with T2DM were recruited. Bone mineral density (BMD) and body composition were measured by the dual-energy X-ray absorptiometry scanner. The homeostasis model assessment of insulin resistance and Matsuda index were used to evaluate insulin resistance status. β-Cell function was estimated by the area under the curve insulin/glucose (AUC-Ins/Glu) and the area under the curve C-peptide/glucose (AUC-CP/Glu). T2DM patients with osteosarcopenia had lower body mass index, waist circumference, body fat percentage, AUC-Ins/Glu, and AUC-CP/Glu. Both AUC-Ins/Glu (OR = 0.634, P = 0.008) and AUC-CP/Glu (OR = 0.491, P = 0.009) were negatively associated with the presence of osteosarcopenia. Multivariate linear regression analysis showed that β-cell function was positively associated with the skeletal muscle mass index, whereas it showed no correlation with lumbar or hip BMD. β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with T2DM. These findings suggest that β-cell function might be a protective factor against osteosarcopenia.Liu JidongYu DongqingXu MingyueFeng RuiyingSun YujingYin XiaofeiLai HongWang ChuanLiu JinboDe Gruyterarticleβ-cell functionosteosarcopeniat2dmskeletal muscle mass indexMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1583-1590 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	β-cell function osteosarcopenia t2dm skeletal muscle mass index Medicine R
spellingShingle	β-cell function osteosarcopenia t2dm skeletal muscle mass index Medicine R Liu Jidong Yu Dongqing Xu Mingyue Feng Ruiying Sun Yujing Yin Xiaofei Lai Hong Wang Chuan Liu Jinbo β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with type 2 diabetes: A cross-sectional study
description	Type 2 diabetes mellitus (T2DM) is a strong risk tfactor for osteosarcopenia. The relationship between musculoskeletal index and β-cell function remains controversial. We aimed to describe the clinical characteristics of osteosarcopenia and to explore the association between osteosarcopenia and β-cell function, as well as insulin resistance in patients with T2DM. A total of 150 middle-aged and older nonobese patients with T2DM were recruited. Bone mineral density (BMD) and body composition were measured by the dual-energy X-ray absorptiometry scanner. The homeostasis model assessment of insulin resistance and Matsuda index were used to evaluate insulin resistance status. β-Cell function was estimated by the area under the curve insulin/glucose (AUC-Ins/Glu) and the area under the curve C-peptide/glucose (AUC-CP/Glu). T2DM patients with osteosarcopenia had lower body mass index, waist circumference, body fat percentage, AUC-Ins/Glu, and AUC-CP/Glu. Both AUC-Ins/Glu (OR = 0.634, P = 0.008) and AUC-CP/Glu (OR = 0.491, P = 0.009) were negatively associated with the presence of osteosarcopenia. Multivariate linear regression analysis showed that β-cell function was positively associated with the skeletal muscle mass index, whereas it showed no correlation with lumbar or hip BMD. β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with T2DM. These findings suggest that β-cell function might be a protective factor against osteosarcopenia.
format	article
author	Liu Jidong Yu Dongqing Xu Mingyue Feng Ruiying Sun Yujing Yin Xiaofei Lai Hong Wang Chuan Liu Jinbo
author_facet	Liu Jidong Yu Dongqing Xu Mingyue Feng Ruiying Sun Yujing Yin Xiaofei Lai Hong Wang Chuan Liu Jinbo
author_sort	Liu Jidong
title	β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with type 2 diabetes: A cross-sectional study
title_short	β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with type 2 diabetes: A cross-sectional study
title_full	β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with type 2 diabetes: A cross-sectional study
title_fullStr	β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with type 2 diabetes: A cross-sectional study
title_full_unstemmed	β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with type 2 diabetes: A cross-sectional study
title_sort	β-cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with type 2 diabetes: a cross-sectional study
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/b7da9cfd1e94415194d76da827998338
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β-Cell function is associated with osteosarcopenia in middle-aged and older nonobese patients with type 2 diabetes: A cross-sectional study

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