Change in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study

Ming Zhong,1– 3 Yi-Ru Yang,4 Yong-Ze Zhang,1– 3 Sun-Jie Yan1– 3 1Department of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People’s Republic of China; 2Fujian Diabetes Research Institute, The First Affiliate...

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Autores principales:	Zhong M, Yang YR, Zhang YZ, Yan SJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetic peripheral neuropathy type 2 diabetes urine albumin-to-creatinine ratio nerve conduction velocity Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b7dc578e430b4642ad733805bbffefd0
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spelling	oai:doaj.org-article:b7dc578e430b4642ad733805bbffefd02021-12-02T16:41:24ZChange in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study1178-7007https://doaj.org/article/b7dc578e430b4642ad733805bbffefd02021-04-01T00:00:00Zhttps://www.dovepress.com/change-in-urine-albumin-to-creatinine-ratio-and-risk-of-diabetic-perip-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Ming Zhong,1– 3 Yi-Ru Yang,4 Yong-Ze Zhang,1– 3 Sun-Jie Yan1– 3 1Department of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People’s Republic of China; 2Fujian Diabetes Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People’s Republic of China; 3Metabolic Diseases Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People’s Republic of China; 4Department of Ultrasound, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, People’s Republic of ChinaCorrespondence: Sun-Jie YanDepartment of Endocrinology, The First Affiliated Hospital, Fujian Medical University, 20 Tea Road, Taijiang District, Fuzhou, 350005, Fujian, People’s Republic of ChinaTel +86-0591-87983333Fax +86-0591-87981685Email fjyansunjie@163.comPurpose: This study aimed to assess association between change in urine albumin-to-creatinine ratio (UACR) and the risk of diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.Patients and Methods: A retrospective study was performed, which included 185 individuals with type 2 diabetes. At baseline, and at two-year follow-up, we collected basic data, recorded symptoms and signs of DPN, measured biochemical indicators, composite motor nerve conduction velocity (composite MCV), and composite sensory nerve conduction velocity (composite SCV).Results: Changes of composite SCV, MCV and TCSS among different changes in UACR in patients without DPN and with DPN were not significantly different. An increase in UACR ≥ 30% (OR 3.059, 95%; CI: 1.012– 9.249) suggested a risk for new-onset DPN. Based on ROC curve analysis, the areas under the curve were 0.654 ± 0.066 for change of UACR levels in non-DPN patients.Conclusion: Change in UACR and NCV was not related in patients without DPN and with DPN; change in UACR ≥ 30% suggested a risk for new-onset DPN.Keywords: diabetic peripheral neuropathy, type 2 diabetes, urine albumin-to-creatinine ratio, nerve conduction velocityZhong MYang YRZhang YZYan SJDove Medical Pressarticlediabetic peripheral neuropathytype 2 diabetesurine albumin-to-creatinine rationerve conduction velocitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1763-1772 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic peripheral neuropathy type 2 diabetes urine albumin-to-creatinine ratio nerve conduction velocity Specialties of internal medicine RC581-951
spellingShingle	diabetic peripheral neuropathy type 2 diabetes urine albumin-to-creatinine ratio nerve conduction velocity Specialties of internal medicine RC581-951 Zhong M Yang YR Zhang YZ Yan SJ Change in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study
description	Ming Zhong,1– 3 Yi-Ru Yang,4 Yong-Ze Zhang,1– 3 Sun-Jie Yan1– 3 1Department of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People’s Republic of China; 2Fujian Diabetes Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People’s Republic of China; 3Metabolic Diseases Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People’s Republic of China; 4Department of Ultrasound, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, People’s Republic of ChinaCorrespondence: Sun-Jie YanDepartment of Endocrinology, The First Affiliated Hospital, Fujian Medical University, 20 Tea Road, Taijiang District, Fuzhou, 350005, Fujian, People’s Republic of ChinaTel +86-0591-87983333Fax +86-0591-87981685Email fjyansunjie@163.comPurpose: This study aimed to assess association between change in urine albumin-to-creatinine ratio (UACR) and the risk of diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.Patients and Methods: A retrospective study was performed, which included 185 individuals with type 2 diabetes. At baseline, and at two-year follow-up, we collected basic data, recorded symptoms and signs of DPN, measured biochemical indicators, composite motor nerve conduction velocity (composite MCV), and composite sensory nerve conduction velocity (composite SCV).Results: Changes of composite SCV, MCV and TCSS among different changes in UACR in patients without DPN and with DPN were not significantly different. An increase in UACR ≥ 30% (OR 3.059, 95%; CI: 1.012– 9.249) suggested a risk for new-onset DPN. Based on ROC curve analysis, the areas under the curve were 0.654 ± 0.066 for change of UACR levels in non-DPN patients.Conclusion: Change in UACR and NCV was not related in patients without DPN and with DPN; change in UACR ≥ 30% suggested a risk for new-onset DPN.Keywords: diabetic peripheral neuropathy, type 2 diabetes, urine albumin-to-creatinine ratio, nerve conduction velocity
format	article
author	Zhong M Yang YR Zhang YZ Yan SJ
author_facet	Zhong M Yang YR Zhang YZ Yan SJ
author_sort	Zhong M
title	Change in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study
title_short	Change in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study
title_full	Change in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study
title_fullStr	Change in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study
title_full_unstemmed	Change in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study
title_sort	change in urine albumin-to-creatinine ratio and risk of diabetic peripheral neuropathy in type 2 diabetes: a retrospective cohort study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/b7dc578e430b4642ad733805bbffefd0
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Change in Urine Albumin-to-Creatinine Ratio and Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Retrospective Cohort Study

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