Monocyte progenitors give rise to multinucleated giant cells

Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.

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Auteurs principaux:	Anne Kathrin Lösslein, Florens Lohrmann, Lisa Scheuermann, Kourosh Gharun, Jana Neuber, Julia Kolter, Aaron James Forde, Christian Kleimeyer, Ying Yee Poh, Matthias Mack, Antigoni Triantafyllopoulou, Micah D. Dunlap, Shabaana A. Khader, Maximilian Seidl, Alexandra Hölscher, Christoph Hölscher, Xue Li Guan, Anca Dorhoi, Philipp Henneke
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/b7de3fe7ad2f4ec7a67aa8fc0ad6eba6
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spelling	oai:doaj.org-article:b7de3fe7ad2f4ec7a67aa8fc0ad6eba62021-12-02T14:23:03ZMonocyte progenitors give rise to multinucleated giant cells10.1038/s41467-021-22103-52041-1723https://doaj.org/article/b7de3fe7ad2f4ec7a67aa8fc0ad6eba62021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22103-5https://doaj.org/toc/2041-1723Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.Anne Kathrin LössleinFlorens LohrmannLisa ScheuermannKourosh GharunJana NeuberJulia KolterAaron James FordeChristian KleimeyerYing Yee PohMatthias MackAntigoni TriantafyllopoulouMicah D. DunlapShabaana A. KhaderMaximilian SeidlAlexandra HölscherChristoph HölscherXue Li GuanAnca DorhoiPhilipp HennekeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anne Kathrin Lösslein Florens Lohrmann Lisa Scheuermann Kourosh Gharun Jana Neuber Julia Kolter Aaron James Forde Christian Kleimeyer Ying Yee Poh Matthias Mack Antigoni Triantafyllopoulou Micah D. Dunlap Shabaana A. Khader Maximilian Seidl Alexandra Hölscher Christoph Hölscher Xue Li Guan Anca Dorhoi Philipp Henneke Monocyte progenitors give rise to multinucleated giant cells
description	Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.
format	article
author	Anne Kathrin Lösslein Florens Lohrmann Lisa Scheuermann Kourosh Gharun Jana Neuber Julia Kolter Aaron James Forde Christian Kleimeyer Ying Yee Poh Matthias Mack Antigoni Triantafyllopoulou Micah D. Dunlap Shabaana A. Khader Maximilian Seidl Alexandra Hölscher Christoph Hölscher Xue Li Guan Anca Dorhoi Philipp Henneke
author_facet	Anne Kathrin Lösslein Florens Lohrmann Lisa Scheuermann Kourosh Gharun Jana Neuber Julia Kolter Aaron James Forde Christian Kleimeyer Ying Yee Poh Matthias Mack Antigoni Triantafyllopoulou Micah D. Dunlap Shabaana A. Khader Maximilian Seidl Alexandra Hölscher Christoph Hölscher Xue Li Guan Anca Dorhoi Philipp Henneke
author_sort	Anne Kathrin Lösslein
title	Monocyte progenitors give rise to multinucleated giant cells
title_short	Monocyte progenitors give rise to multinucleated giant cells
title_full	Monocyte progenitors give rise to multinucleated giant cells
title_fullStr	Monocyte progenitors give rise to multinucleated giant cells
title_full_unstemmed	Monocyte progenitors give rise to multinucleated giant cells
title_sort	monocyte progenitors give rise to multinucleated giant cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b7de3fe7ad2f4ec7a67aa8fc0ad6eba6
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Monocyte progenitors give rise to multinucleated giant cells

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