Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

The development of post-chemotherapy resistance is a significant issue in the management of AML. Here, Caiado et al. suggest that the issue might be circumvented via upfront combination with hypomethylating agents that shape the clonal dynamics and transcriptional landscape of relapsing AML

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Autores principales:	Francisco Caiado, Diogo Maia-Silva, Carolina Jardim, Nina Schmolka, Tânia Carvalho, Cláudia Reforço, Rita Faria, Branka Kolundzija, André E. Simões, Tuncay Baubec, Christopher R. Vakoc, Maria Gomes da Silva, Markus G. Manz, Ton N. Schumacher, Håkan Norell, Bruno Silva-Santos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7dfc820cd8046b7b9099018be4d92e6
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spelling	oai:doaj.org-article:b7dfc820cd8046b7b9099018be4d92e62021-12-02T14:38:43ZLineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection10.1038/s41467-019-12983-z2041-1723https://doaj.org/article/b7dfc820cd8046b7b9099018be4d92e62019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12983-zhttps://doaj.org/toc/2041-1723The development of post-chemotherapy resistance is a significant issue in the management of AML. Here, Caiado et al. suggest that the issue might be circumvented via upfront combination with hypomethylating agents that shape the clonal dynamics and transcriptional landscape of relapsing AMLFrancisco CaiadoDiogo Maia-SilvaCarolina JardimNina SchmolkaTânia CarvalhoCláudia ReforçoRita FariaBranka KolundzijaAndré E. SimõesTuncay BaubecChristopher R. VakocMaria Gomes da SilvaMarkus G. ManzTon N. SchumacherHåkan NorellBruno Silva-SantosNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francisco Caiado Diogo Maia-Silva Carolina Jardim Nina Schmolka Tânia Carvalho Cláudia Reforço Rita Faria Branka Kolundzija André E. Simões Tuncay Baubec Christopher R. Vakoc Maria Gomes da Silva Markus G. Manz Ton N. Schumacher Håkan Norell Bruno Silva-Santos Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection
description	The development of post-chemotherapy resistance is a significant issue in the management of AML. Here, Caiado et al. suggest that the issue might be circumvented via upfront combination with hypomethylating agents that shape the clonal dynamics and transcriptional landscape of relapsing AML
format	article
author	Francisco Caiado Diogo Maia-Silva Carolina Jardim Nina Schmolka Tânia Carvalho Cláudia Reforço Rita Faria Branka Kolundzija André E. Simões Tuncay Baubec Christopher R. Vakoc Maria Gomes da Silva Markus G. Manz Ton N. Schumacher Håkan Norell Bruno Silva-Santos
author_facet	Francisco Caiado Diogo Maia-Silva Carolina Jardim Nina Schmolka Tânia Carvalho Cláudia Reforço Rita Faria Branka Kolundzija André E. Simões Tuncay Baubec Christopher R. Vakoc Maria Gomes da Silva Markus G. Manz Ton N. Schumacher Håkan Norell Bruno Silva-Santos
author_sort	Francisco Caiado
title	Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection
title_short	Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection
title_full	Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection
title_fullStr	Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection
title_full_unstemmed	Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection
title_sort	lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b7dfc820cd8046b7b9099018be4d92e6
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Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

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