Structural basis for allosteric regulation of Human Topoisomerase IIα

Type 2 DNA topoisomerases (Top2) regulates DNA topology during DNA replication, transcription, and chromosome segregation. Here the authors describe a complete structure of the catalytic core of the human Topo IIα bound to DNA and etoposide, providing insight into the regulation of Topo IIα activiti...

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Autores principales:	Arnaud Vanden Broeck, Christophe Lotz, Robert Drillien, Léa Haas, Claire Bedez, Valérie Lamour
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7e2a03d00154a469e0713b5f5c0f525
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spelling	oai:doaj.org-article:b7e2a03d00154a469e0713b5f5c0f5252021-12-02T15:45:24ZStructural basis for allosteric regulation of Human Topoisomerase IIα10.1038/s41467-021-23136-62041-1723https://doaj.org/article/b7e2a03d00154a469e0713b5f5c0f5252021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23136-6https://doaj.org/toc/2041-1723Type 2 DNA topoisomerases (Top2) regulates DNA topology during DNA replication, transcription, and chromosome segregation. Here the authors describe a complete structure of the catalytic core of the human Topo IIα bound to DNA and etoposide, providing insight into the regulation of Topo IIα activities and how opening of the DNA-gate is spatially connected to the ATPase domain.Arnaud Vanden BroeckChristophe LotzRobert DrillienLéa HaasClaire BedezValérie LamourNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arnaud Vanden Broeck Christophe Lotz Robert Drillien Léa Haas Claire Bedez Valérie Lamour Structural basis for allosteric regulation of Human Topoisomerase IIα
description	Type 2 DNA topoisomerases (Top2) regulates DNA topology during DNA replication, transcription, and chromosome segregation. Here the authors describe a complete structure of the catalytic core of the human Topo IIα bound to DNA and etoposide, providing insight into the regulation of Topo IIα activities and how opening of the DNA-gate is spatially connected to the ATPase domain.
format	article
author	Arnaud Vanden Broeck Christophe Lotz Robert Drillien Léa Haas Claire Bedez Valérie Lamour
author_facet	Arnaud Vanden Broeck Christophe Lotz Robert Drillien Léa Haas Claire Bedez Valérie Lamour
author_sort	Arnaud Vanden Broeck
title	Structural basis for allosteric regulation of Human Topoisomerase IIα
title_short	Structural basis for allosteric regulation of Human Topoisomerase IIα
title_full	Structural basis for allosteric regulation of Human Topoisomerase IIα
title_fullStr	Structural basis for allosteric regulation of Human Topoisomerase IIα
title_full_unstemmed	Structural basis for allosteric regulation of Human Topoisomerase IIα
title_sort	structural basis for allosteric regulation of human topoisomerase iiα
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b7e2a03d00154a469e0713b5f5c0f525
work_keys_str_mv	AT arnaudvandenbroeck structuralbasisforallostericregulationofhumantopoisomeraseiia AT christophelotz structuralbasisforallostericregulationofhumantopoisomeraseiia AT robertdrillien structuralbasisforallostericregulationofhumantopoisomeraseiia AT leahaas structuralbasisforallostericregulationofhumantopoisomeraseiia AT clairebedez structuralbasisforallostericregulationofhumantopoisomeraseiia AT valerielamour structuralbasisforallostericregulationofhumantopoisomeraseiia
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Structural basis for allosteric regulation of Human Topoisomerase IIα

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