The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network

Abstract To investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth...

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Autores principales:	Jannica S. Selenius, Patricia P. Silveira, Minna Salonen, Hannu Kautiainen, Mikaela von Bonsdorff, Eero Kajantie, Jari Lahti, Johan G. Eriksson, Niko S. Wasenius
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7e37020fe1b44d782510a4e39e5d913
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spelling	oai:doaj.org-article:b7e37020fe1b44d782510a4e39e5d9132021-11-08T10:48:37ZThe relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network10.1038/s41598-021-00631-w2045-2322https://doaj.org/article/b7e37020fe1b44d782510a4e39e5d9132021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00631-whttps://doaj.org/toc/2045-2322Abstract To investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components of HRQoL and Beck Depression Inventory (BDI) to assess depressive symptoms. Depressive symptoms were categorized into minimal (BDI < 10), non-melancholic and melancholic types of depression. The ePRS-IRs were calculated for the hippocampal (hePRS-IR) and the mesocorticolimbic (mePRS-IR) regions of the brain. General linear regression models adjusted for age, sex, population stratification, lifestyle factors and body mass index were applied to analyze the data. Both types of depressive symptoms were associated with lower HRQoL (p < 0.0001). HePRS-IR modified the association between the types of depression and mental HRQoL (p for interaction = 0.005). Melancholic type of depressive symptoms was associated with higher mental HRQoL compared to the non-melancholic symptoms among individuals with low hePRS-IR (adjusted mean 4.1, 95% CI 0.7–7.4, p = 0.018). However, no such difference was evident in moderate or high hePRS-IR groups as higher hePRS-IR was associated with lower mental HRQoL (B = − 3.4, 95% CI − 5.6 to − 1.2) in individuals with melancholic type of depressive symptoms. No direct associations were detected between the ePRS-IRs and type of depressive symptoms or HRQoL. Variations in the glucose-insulin metabolism can lower HRQoL in individuals with melancholic depressive symptoms.Jannica S. SeleniusPatricia P. SilveiraMinna SalonenHannu KautiainenMikaela von BonsdorffEero KajantieJari LahtiJohan G. ErikssonNiko S. WaseniusNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jannica S. Selenius Patricia P. Silveira Minna Salonen Hannu Kautiainen Mikaela von Bonsdorff Eero Kajantie Jari Lahti Johan G. Eriksson Niko S. Wasenius The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network
description	Abstract To investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components of HRQoL and Beck Depression Inventory (BDI) to assess depressive symptoms. Depressive symptoms were categorized into minimal (BDI < 10), non-melancholic and melancholic types of depression. The ePRS-IRs were calculated for the hippocampal (hePRS-IR) and the mesocorticolimbic (mePRS-IR) regions of the brain. General linear regression models adjusted for age, sex, population stratification, lifestyle factors and body mass index were applied to analyze the data. Both types of depressive symptoms were associated with lower HRQoL (p < 0.0001). HePRS-IR modified the association between the types of depression and mental HRQoL (p for interaction = 0.005). Melancholic type of depressive symptoms was associated with higher mental HRQoL compared to the non-melancholic symptoms among individuals with low hePRS-IR (adjusted mean 4.1, 95% CI 0.7–7.4, p = 0.018). However, no such difference was evident in moderate or high hePRS-IR groups as higher hePRS-IR was associated with lower mental HRQoL (B = − 3.4, 95% CI − 5.6 to − 1.2) in individuals with melancholic type of depressive symptoms. No direct associations were detected between the ePRS-IRs and type of depressive symptoms or HRQoL. Variations in the glucose-insulin metabolism can lower HRQoL in individuals with melancholic depressive symptoms.
format	article
author	Jannica S. Selenius Patricia P. Silveira Minna Salonen Hannu Kautiainen Mikaela von Bonsdorff Eero Kajantie Jari Lahti Johan G. Eriksson Niko S. Wasenius
author_facet	Jannica S. Selenius Patricia P. Silveira Minna Salonen Hannu Kautiainen Mikaela von Bonsdorff Eero Kajantie Jari Lahti Johan G. Eriksson Niko S. Wasenius
author_sort	Jannica S. Selenius
title	The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network
title_short	The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network
title_full	The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network
title_fullStr	The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network
title_full_unstemmed	The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network
title_sort	relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b7e37020fe1b44d782510a4e39e5d913
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The relationship between health-related quality of life and melancholic depressive symptoms is modified by brain insulin receptor gene network

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