Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant

Neonatal vitamin K prophylaxis is essential to prevent vitamin K deficiency bleeding (VKDB) with a clear benefit compared to placebo. Various routes (intramuscular (IM), oral, intravenous (IV)) and dosing regimens were explored. A literature review was conducted to compare vitamin K regimens on VKDB...

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Autores principales: Simon Fiesack, Anne Smits, Maissa Rayyan, Karel Allegaert, Philippe Alliet, Wim Arts, An Bael, Luc Cornette, Ann De Guchtenaere, Nele De Mulder, Isabel George, Elisabeth Henrion, Kirsten Keiren, Nathalie Kreins, Marc Raes, Pierre Philippet, Bart Van Overmeire, Myriam Van Winckel, Vinciane Vlieghe, Yvan Vandenplas, on behalf of the Groups
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Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/b7e5d47cc59a483f873f17bde9f3888c
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spelling oai:doaj.org-article:b7e5d47cc59a483f873f17bde9f3888c2021-11-25T18:36:50ZBelgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant10.3390/nu131141092072-6643https://doaj.org/article/b7e5d47cc59a483f873f17bde9f3888c2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4109https://doaj.org/toc/2072-6643Neonatal vitamin K prophylaxis is essential to prevent vitamin K deficiency bleeding (VKDB) with a clear benefit compared to placebo. Various routes (intramuscular (IM), oral, intravenous (IV)) and dosing regimens were explored. A literature review was conducted to compare vitamin K regimens on VKDB incidence. Simultaneously, information on practices was collected from Belgian pediatric and neonatal departments. Based on the review and these practices, a consensus was developed and voted on by all co-authors and heads of pediatric departments. Today, practices vary. In line with literature, the advised prophylactic regimen is 1 or 2 mg IM vitamin K once at birth. In the case of parental refusal, healthcare providers should inform parents of the slightly inferior alternative (2 mg oral vitamin K at birth, followed by 1 or 2 mg oral weekly for 3 months when breastfed). We recommend 1 mg IM in preterm <32 weeks, and the same alternative in the case of parental refusal. When IM is perceived impossible in preterm <32 weeks, 0.5 mg IV once is recommended, with a single additional IM 1 mg dose when IV lipids are discontinued. This recommendation is a step towards harmonizing vitamin K prophylaxis in all newborns.Simon FiesackAnne SmitsMaissa RayyanKarel AllegaertPhilippe AllietWim ArtsAn BaelLuc CornetteAnn De GuchtenaereNele De MulderIsabel GeorgeElisabeth HenrionKirsten KeirenNathalie KreinsMarc RaesPierre PhilippetBart Van OvermeireMyriam Van WinckelVinciane VliegheYvan Vandenplason behalf of the GroupsMDPI AGarticlevitamin Kvitamin K deficiency bleedingtermpretermprophylaxisNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4109, p 4109 (2021)
institution DOAJ
collection DOAJ
language EN
topic vitamin K
vitamin K deficiency bleeding
term
preterm
prophylaxis
Nutrition. Foods and food supply
TX341-641
spellingShingle vitamin K
vitamin K deficiency bleeding
term
preterm
prophylaxis
Nutrition. Foods and food supply
TX341-641
Simon Fiesack
Anne Smits
Maissa Rayyan
Karel Allegaert
Philippe Alliet
Wim Arts
An Bael
Luc Cornette
Ann De Guchtenaere
Nele De Mulder
Isabel George
Elisabeth Henrion
Kirsten Keiren
Nathalie Kreins
Marc Raes
Pierre Philippet
Bart Van Overmeire
Myriam Van Winckel
Vinciane Vlieghe
Yvan Vandenplas
on behalf of the Groups
Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant
description Neonatal vitamin K prophylaxis is essential to prevent vitamin K deficiency bleeding (VKDB) with a clear benefit compared to placebo. Various routes (intramuscular (IM), oral, intravenous (IV)) and dosing regimens were explored. A literature review was conducted to compare vitamin K regimens on VKDB incidence. Simultaneously, information on practices was collected from Belgian pediatric and neonatal departments. Based on the review and these practices, a consensus was developed and voted on by all co-authors and heads of pediatric departments. Today, practices vary. In line with literature, the advised prophylactic regimen is 1 or 2 mg IM vitamin K once at birth. In the case of parental refusal, healthcare providers should inform parents of the slightly inferior alternative (2 mg oral vitamin K at birth, followed by 1 or 2 mg oral weekly for 3 months when breastfed). We recommend 1 mg IM in preterm <32 weeks, and the same alternative in the case of parental refusal. When IM is perceived impossible in preterm <32 weeks, 0.5 mg IV once is recommended, with a single additional IM 1 mg dose when IV lipids are discontinued. This recommendation is a step towards harmonizing vitamin K prophylaxis in all newborns.
format article
author Simon Fiesack
Anne Smits
Maissa Rayyan
Karel Allegaert
Philippe Alliet
Wim Arts
An Bael
Luc Cornette
Ann De Guchtenaere
Nele De Mulder
Isabel George
Elisabeth Henrion
Kirsten Keiren
Nathalie Kreins
Marc Raes
Pierre Philippet
Bart Van Overmeire
Myriam Van Winckel
Vinciane Vlieghe
Yvan Vandenplas
on behalf of the Groups
author_facet Simon Fiesack
Anne Smits
Maissa Rayyan
Karel Allegaert
Philippe Alliet
Wim Arts
An Bael
Luc Cornette
Ann De Guchtenaere
Nele De Mulder
Isabel George
Elisabeth Henrion
Kirsten Keiren
Nathalie Kreins
Marc Raes
Pierre Philippet
Bart Van Overmeire
Myriam Van Winckel
Vinciane Vlieghe
Yvan Vandenplas
on behalf of the Groups
author_sort Simon Fiesack
title Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant
title_short Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant
title_full Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant
title_fullStr Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant
title_full_unstemmed Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant
title_sort belgian consensus recommendations to prevent vitamin k deficiency bleeding in the term and preterm infant
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/b7e5d47cc59a483f873f17bde9f3888c
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