Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant
Neonatal vitamin K prophylaxis is essential to prevent vitamin K deficiency bleeding (VKDB) with a clear benefit compared to placebo. Various routes (intramuscular (IM), oral, intravenous (IV)) and dosing regimens were explored. A literature review was conducted to compare vitamin K regimens on VKDB...
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oai:doaj.org-article:b7e5d47cc59a483f873f17bde9f3888c2021-11-25T18:36:50ZBelgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant10.3390/nu131141092072-6643https://doaj.org/article/b7e5d47cc59a483f873f17bde9f3888c2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4109https://doaj.org/toc/2072-6643Neonatal vitamin K prophylaxis is essential to prevent vitamin K deficiency bleeding (VKDB) with a clear benefit compared to placebo. Various routes (intramuscular (IM), oral, intravenous (IV)) and dosing regimens were explored. A literature review was conducted to compare vitamin K regimens on VKDB incidence. Simultaneously, information on practices was collected from Belgian pediatric and neonatal departments. Based on the review and these practices, a consensus was developed and voted on by all co-authors and heads of pediatric departments. Today, practices vary. In line with literature, the advised prophylactic regimen is 1 or 2 mg IM vitamin K once at birth. In the case of parental refusal, healthcare providers should inform parents of the slightly inferior alternative (2 mg oral vitamin K at birth, followed by 1 or 2 mg oral weekly for 3 months when breastfed). We recommend 1 mg IM in preterm <32 weeks, and the same alternative in the case of parental refusal. When IM is perceived impossible in preterm <32 weeks, 0.5 mg IV once is recommended, with a single additional IM 1 mg dose when IV lipids are discontinued. This recommendation is a step towards harmonizing vitamin K prophylaxis in all newborns.Simon FiesackAnne SmitsMaissa RayyanKarel AllegaertPhilippe AllietWim ArtsAn BaelLuc CornetteAnn De GuchtenaereNele De MulderIsabel GeorgeElisabeth HenrionKirsten KeirenNathalie KreinsMarc RaesPierre PhilippetBart Van OvermeireMyriam Van WinckelVinciane VliegheYvan Vandenplason behalf of the GroupsMDPI AGarticlevitamin Kvitamin K deficiency bleedingtermpretermprophylaxisNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4109, p 4109 (2021) |
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vitamin K vitamin K deficiency bleeding term preterm prophylaxis Nutrition. Foods and food supply TX341-641 |
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vitamin K vitamin K deficiency bleeding term preterm prophylaxis Nutrition. Foods and food supply TX341-641 Simon Fiesack Anne Smits Maissa Rayyan Karel Allegaert Philippe Alliet Wim Arts An Bael Luc Cornette Ann De Guchtenaere Nele De Mulder Isabel George Elisabeth Henrion Kirsten Keiren Nathalie Kreins Marc Raes Pierre Philippet Bart Van Overmeire Myriam Van Winckel Vinciane Vlieghe Yvan Vandenplas on behalf of the Groups Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant |
description |
Neonatal vitamin K prophylaxis is essential to prevent vitamin K deficiency bleeding (VKDB) with a clear benefit compared to placebo. Various routes (intramuscular (IM), oral, intravenous (IV)) and dosing regimens were explored. A literature review was conducted to compare vitamin K regimens on VKDB incidence. Simultaneously, information on practices was collected from Belgian pediatric and neonatal departments. Based on the review and these practices, a consensus was developed and voted on by all co-authors and heads of pediatric departments. Today, practices vary. In line with literature, the advised prophylactic regimen is 1 or 2 mg IM vitamin K once at birth. In the case of parental refusal, healthcare providers should inform parents of the slightly inferior alternative (2 mg oral vitamin K at birth, followed by 1 or 2 mg oral weekly for 3 months when breastfed). We recommend 1 mg IM in preterm <32 weeks, and the same alternative in the case of parental refusal. When IM is perceived impossible in preterm <32 weeks, 0.5 mg IV once is recommended, with a single additional IM 1 mg dose when IV lipids are discontinued. This recommendation is a step towards harmonizing vitamin K prophylaxis in all newborns. |
format |
article |
author |
Simon Fiesack Anne Smits Maissa Rayyan Karel Allegaert Philippe Alliet Wim Arts An Bael Luc Cornette Ann De Guchtenaere Nele De Mulder Isabel George Elisabeth Henrion Kirsten Keiren Nathalie Kreins Marc Raes Pierre Philippet Bart Van Overmeire Myriam Van Winckel Vinciane Vlieghe Yvan Vandenplas on behalf of the Groups |
author_facet |
Simon Fiesack Anne Smits Maissa Rayyan Karel Allegaert Philippe Alliet Wim Arts An Bael Luc Cornette Ann De Guchtenaere Nele De Mulder Isabel George Elisabeth Henrion Kirsten Keiren Nathalie Kreins Marc Raes Pierre Philippet Bart Van Overmeire Myriam Van Winckel Vinciane Vlieghe Yvan Vandenplas on behalf of the Groups |
author_sort |
Simon Fiesack |
title |
Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant |
title_short |
Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant |
title_full |
Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant |
title_fullStr |
Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant |
title_full_unstemmed |
Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant |
title_sort |
belgian consensus recommendations to prevent vitamin k deficiency bleeding in the term and preterm infant |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/b7e5d47cc59a483f873f17bde9f3888c |
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