Minocycline as adjunct therapy for a male patient with deficit schizophrenia

Xiaohua Chen,1,* Zhenzhen Xiong,2,* Zhixiong Li,3 Yali Yang,4 Zhanying Zheng,5 Yonghong Li,6 Yan Xie,6 Zhe Li7,8 1Department of Central Transportation Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; 2School of Nursing, Chengdu Medical College, Chengdu, Sichuan 61008...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chen X, Xiong Z, Li Z, Yang Y, Zheng Z, Li Y, Xie Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Minocycline Adjunct therapy Deficit schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b7e8b878cb4a405c987b57fb7dfac5d5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b7e8b878cb4a405c987b57fb7dfac5d5
record_format	dspace
spelling	oai:doaj.org-article:b7e8b878cb4a405c987b57fb7dfac5d52021-12-02T06:58:58ZMinocycline as adjunct therapy for a male patient with deficit schizophrenia1178-2021https://doaj.org/article/b7e8b878cb4a405c987b57fb7dfac5d52018-10-01T00:00:00Zhttps://www.dovepress.com/minocycline-as-adjunct-therapy-for-a-male-patient-with-deficit-schizop-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xiaohua Chen,1,* Zhenzhen Xiong,2,* Zhixiong Li,3 Yali Yang,4 Zhanying Zheng,5 Yonghong Li,6 Yan Xie,6 Zhe Li7,8 1Department of Central Transportation Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; 2School of Nursing, Chengdu Medical College, Chengdu, Sichuan 610083, China; 3The Third Department of Clinical Psychology, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 4The Second Department of Clinical Psychology, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 5The First Department of Clinical Psychology, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 6The Sleep Medicine Department, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 7Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; 8The Mental Rehabilitation Center, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China *These authors contributed equally to this work Abstract: The pathophysiology of schizophrenia may involve increased production of inflammatory cytokines by activated microglia. Minocycline can inhibit activated microglia and may improve secondary negative symptoms and/or cognitive functions when used as adjuvant to antipsychotics. Effects on minocycline on primary and enduring negative symptoms in deficit schizophrenia (DS) are unknown. We present a male patient with a 3-year history of DS. He was treated for 12 weeks with risperidone at a maximal dose of 6 mg per day, then for 10 weeks with olanzapine at 20 mg per day. Symptoms did not improve, and body mass index increased from 20.41 to 22.84 kg/m2. Serum levels of several inflammatory cytokines were elevated, so we prescribed minocycline as adjunct to aripiprazole for 12 weeks. Negative symptoms and cognitive impairment improved, and serum levels of inflammatory cytokines decreased. Our case suggests that clinicians may consider minocycline as adjunct therapy to antipsychotics in patients with DS with elevated serum levels of inflammatory cytokines. This highlights the need for further research into possible relationships of minocycline with negative symptoms and cognitive function in patients with DS. Keywords: minocycline, adjunct therapy, deficit schizophreniaChen XXiong ZLi ZYang YZheng ZLi YXie YLi ZDove Medical PressarticleMinocyclineAdjunct therapyDeficit schizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2697-2701 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Minocycline Adjunct therapy Deficit schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Minocycline Adjunct therapy Deficit schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chen X Xiong Z Li Z Yang Y Zheng Z Li Y Xie Y Li Z Minocycline as adjunct therapy for a male patient with deficit schizophrenia
description	Xiaohua Chen,1,* Zhenzhen Xiong,2,* Zhixiong Li,3 Yali Yang,4 Zhanying Zheng,5 Yonghong Li,6 Yan Xie,6 Zhe Li7,8 1Department of Central Transportation Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; 2School of Nursing, Chengdu Medical College, Chengdu, Sichuan 610083, China; 3The Third Department of Clinical Psychology, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 4The Second Department of Clinical Psychology, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 5The First Department of Clinical Psychology, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 6The Sleep Medicine Department, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China; 7Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; 8The Mental Rehabilitation Center, Karamay Municipal People’s Hospital, Karamay, Xinjiang 830054, China *These authors contributed equally to this work Abstract: The pathophysiology of schizophrenia may involve increased production of inflammatory cytokines by activated microglia. Minocycline can inhibit activated microglia and may improve secondary negative symptoms and/or cognitive functions when used as adjuvant to antipsychotics. Effects on minocycline on primary and enduring negative symptoms in deficit schizophrenia (DS) are unknown. We present a male patient with a 3-year history of DS. He was treated for 12 weeks with risperidone at a maximal dose of 6 mg per day, then for 10 weeks with olanzapine at 20 mg per day. Symptoms did not improve, and body mass index increased from 20.41 to 22.84 kg/m2. Serum levels of several inflammatory cytokines were elevated, so we prescribed minocycline as adjunct to aripiprazole for 12 weeks. Negative symptoms and cognitive impairment improved, and serum levels of inflammatory cytokines decreased. Our case suggests that clinicians may consider minocycline as adjunct therapy to antipsychotics in patients with DS with elevated serum levels of inflammatory cytokines. This highlights the need for further research into possible relationships of minocycline with negative symptoms and cognitive function in patients with DS. Keywords: minocycline, adjunct therapy, deficit schizophrenia
format	article
author	Chen X Xiong Z Li Z Yang Y Zheng Z Li Y Xie Y Li Z
author_facet	Chen X Xiong Z Li Z Yang Y Zheng Z Li Y Xie Y Li Z
author_sort	Chen X
title	Minocycline as adjunct therapy for a male patient with deficit schizophrenia
title_short	Minocycline as adjunct therapy for a male patient with deficit schizophrenia
title_full	Minocycline as adjunct therapy for a male patient with deficit schizophrenia
title_fullStr	Minocycline as adjunct therapy for a male patient with deficit schizophrenia
title_full_unstemmed	Minocycline as adjunct therapy for a male patient with deficit schizophrenia
title_sort	minocycline as adjunct therapy for a male patient with deficit schizophrenia
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/b7e8b878cb4a405c987b57fb7dfac5d5
work_keys_str_mv	AT chenx minocyclineasadjuncttherapyforamalepatientwithdeficitschizophrenia AT xiongz minocyclineasadjuncttherapyforamalepatientwithdeficitschizophrenia AT liz minocyclineasadjuncttherapyforamalepatientwithdeficitschizophrenia AT yangy minocyclineasadjuncttherapyforamalepatientwithdeficitschizophrenia AT zhengz minocyclineasadjuncttherapyforamalepatientwithdeficitschizophrenia AT liy minocyclineasadjuncttherapyforamalepatientwithdeficitschizophrenia AT xiey minocyclineasadjuncttherapyforamalepatientwithdeficitschizophrenia AT liz minocyclineasadjuncttherapyforamalepatientwithdeficitschizophrenia
_version_	1718399656940011520

Minocycline as adjunct therapy for a male patient with deficit schizophrenia

Ejemplares similares