Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits

Judy Chan1, Gamal M El Maghraby1,2, Jennifer P Craig3, Raid G Alany11Drug Delivery Research Unit (2DRU), School of Pharmacy, The University of Auckland, Auckland, New Zealand; 2Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 3Department of Ophthalmology,...

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Autores principales:	Judy Chan, Gamal M El Maghraby, Jennifer P Craig, Raid G Alany
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b7ea041711bd4ac28efc29315f559820
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spelling	oai:doaj.org-article:b7ea041711bd4ac28efc29315f5598202021-12-02T06:08:40ZEffect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits1177-54671177-5483https://doaj.org/article/b7ea041711bd4ac28efc29315f5598202008-03-01T00:00:00Zhttp://www.dovepress.com/effect-of-water-in-oil-microemulsions-and-lamellar-liquid-crystalline--a349https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Judy Chan1, Gamal M El Maghraby1,2, Jennifer P Craig3, Raid G Alany11Drug Delivery Research Unit (2DRU), School of Pharmacy, The University of Auckland, Auckland, New Zealand; 2Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 3Department of Ophthalmology, The University of Auckland, Auckland, New ZealandAbstract: The aim of this study is to investigate the effect of phase transition water-in-oil (w/o) microemulsions (ME) and liquid crystalline systems (LC) on the precorneal tear film (PCTF). The study used six albino NZ rabbits and monitored the integrity and stability of the PCTF before and after instillation of test formulations. The effects were evaluated by assessment of the PCTF lipid layer using interferometry, tear evaporation rate measurements, and indirect estimation of tear volume. Ocular application of test formulations changed the appearance of the PCTF lipid layer, indicating lipid layer disruption. The recovery time was longer in case of ME compared with an aqueous solution (SOL). The tear evaporation rate was increased after application of both ME and LC systems compared with the SOL, with the LC system showing the greatest effect. Tear volume measurement results revealed minimal changes associated with the instillation of both ME systems. Whilst phase transition w/o ME systems can interact with the PCTF lipid layer in albino New Zealand rabbits, their effect on the volume of resident tears was found to be minimal.Keywords: ocular microemulsion; tear film; dry eye Judy ChanGamal M El MaghrabyJennifer P CraigRaid G AlanyDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 1, Pp 129-137 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Judy Chan Gamal M El Maghraby Jennifer P Craig Raid G Alany Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits
description	Judy Chan1, Gamal M El Maghraby1,2, Jennifer P Craig3, Raid G Alany11Drug Delivery Research Unit (2DRU), School of Pharmacy, The University of Auckland, Auckland, New Zealand; 2Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 3Department of Ophthalmology, The University of Auckland, Auckland, New ZealandAbstract: The aim of this study is to investigate the effect of phase transition water-in-oil (w/o) microemulsions (ME) and liquid crystalline systems (LC) on the precorneal tear film (PCTF). The study used six albino NZ rabbits and monitored the integrity and stability of the PCTF before and after instillation of test formulations. The effects were evaluated by assessment of the PCTF lipid layer using interferometry, tear evaporation rate measurements, and indirect estimation of tear volume. Ocular application of test formulations changed the appearance of the PCTF lipid layer, indicating lipid layer disruption. The recovery time was longer in case of ME compared with an aqueous solution (SOL). The tear evaporation rate was increased after application of both ME and LC systems compared with the SOL, with the LC system showing the greatest effect. Tear volume measurement results revealed minimal changes associated with the instillation of both ME systems. Whilst phase transition w/o ME systems can interact with the PCTF lipid layer in albino New Zealand rabbits, their effect on the volume of resident tears was found to be minimal.Keywords: ocular microemulsion; tear film; dry eye
format	article
author	Judy Chan Gamal M El Maghraby Jennifer P Craig Raid G Alany
author_facet	Judy Chan Gamal M El Maghraby Jennifer P Craig Raid G Alany
author_sort	Judy Chan
title	Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits
title_short	Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits
title_full	Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits
title_fullStr	Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits
title_full_unstemmed	Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits
title_sort	effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino new zealand rabbits
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/b7ea041711bd4ac28efc29315f559820
work_keys_str_mv	AT judychan effectofwaterinoilmicroemulsionsandlamellarliquidcrystallinesystemsontheprecornealtearfilmofalbinonewzealandrabbits AT gamalmelmaghraby effectofwaterinoilmicroemulsionsandlamellarliquidcrystallinesystemsontheprecornealtearfilmofalbinonewzealandrabbits AT jenniferpcraig effectofwaterinoilmicroemulsionsandlamellarliquidcrystallinesystemsontheprecornealtearfilmofalbinonewzealandrabbits AT raidgalany effectofwaterinoilmicroemulsionsandlamellarliquidcrystallinesystemsontheprecornealtearfilmofalbinonewzealandrabbits
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Effect of water-in-oil microemulsions and lamellar liquid crystalline systems on the precorneal tear film of albino New Zealand rabbits

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