Is There a Correlation between Multiparametric Assessment in Ultrasound and Intrinsic Subtype of Breast Cancer?

Molecular profile of breast cancer provides information about its biological activity, prognosis and treatment strategies. The purpose of our study was to investigate the correlation between ultrasound features and molecular subtypes of breast cancer. From June 2019 to December 2019, 86 patients (me...

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Autores principales:	Magdalena Gumowska, Joanna Mączewska, Piotr Prostko, Katarzyna Roszkowska-Purska, Katarzyna Dobruch-Sobczak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	breast cancer ultrasound features multiparametric assessment Medicine R
Acceso en línea:	https://doaj.org/article/b7ef895f147a498fa0d28de7b6092002
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spelling	oai:doaj.org-article:b7ef895f147a498fa0d28de7b60920022021-11-25T18:02:23ZIs There a Correlation between Multiparametric Assessment in Ultrasound and Intrinsic Subtype of Breast Cancer?10.3390/jcm102253942077-0383https://doaj.org/article/b7ef895f147a498fa0d28de7b60920022021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5394https://doaj.org/toc/2077-0383Molecular profile of breast cancer provides information about its biological activity, prognosis and treatment strategies. The purpose of our study was to investigate the correlation between ultrasound features and molecular subtypes of breast cancer. From June 2019 to December 2019, 86 patients (median age 57 years; range 32–88) with 102 breast cancer tumors were included in the study. The molecular subtypes were classified into five types: luminal A (LA), luminal B without HER2 overexpression (LB HER2−), luminal B with HER2 overexpression (LB HER2+), human epidermal growth factor receptor 2 positive (HER2+) and triple negative breast cancer (TNBC). Histopathological verification was obtained in core biopsy or/and post-surgery specimens in all cases. Univariate logistic regression analysis was performed to assess the association between the subtypes and ultrasound imaging features. Experienced radiologists assessed lesions according to the BIRADS-US lexicon. The ultrasound scans were performed with a Supersonic Aixplorer and Supersonix. Based on histopathological verification, the rates of LA, LB HER2−, LB HER2+, HER2+, and TNBC were 33, 17, 17, 16, 19, respectively. Both LB HER2+ and HER2+ subtypes presented higher incidence of calcification (OR = 3.125, <i>p</i> = 0.02, CI 0.0917–5.87) and HER2+ subtype presented a higher incidence of posterior enhancement (OR = 5.75, <i>p</i> = 0.03, CI 1.2257–32.8005), compared to other subtypes. The calcifications were less common in TNBC (OR = 0.176, <i>p</i> = 0.0041, CI 0.0469–0.5335) compared to other subtypes. There were no differences with regard to margin, shape, orientation, elasticity values and vascularity among five molecular subtypes. Our results suggest that there is a correlation between ultrasonographic features assessed according to BIRADS-US lexicon and BC subtypes with HER2 overexpression (both LB HER2+ and HER2+). It may be useful for identification of these aggressive subtypes of breast cancer.Magdalena GumowskaJoanna MączewskaPiotr ProstkoKatarzyna Roszkowska-PurskaKatarzyna Dobruch-SobczakMDPI AGarticlebreast cancerultrasound featuresmultiparametric assessmentMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5394, p 5394 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer ultrasound features multiparametric assessment Medicine R
spellingShingle	breast cancer ultrasound features multiparametric assessment Medicine R Magdalena Gumowska Joanna Mączewska Piotr Prostko Katarzyna Roszkowska-Purska Katarzyna Dobruch-Sobczak Is There a Correlation between Multiparametric Assessment in Ultrasound and Intrinsic Subtype of Breast Cancer?
description	Molecular profile of breast cancer provides information about its biological activity, prognosis and treatment strategies. The purpose of our study was to investigate the correlation between ultrasound features and molecular subtypes of breast cancer. From June 2019 to December 2019, 86 patients (median age 57 years; range 32–88) with 102 breast cancer tumors were included in the study. The molecular subtypes were classified into five types: luminal A (LA), luminal B without HER2 overexpression (LB HER2−), luminal B with HER2 overexpression (LB HER2+), human epidermal growth factor receptor 2 positive (HER2+) and triple negative breast cancer (TNBC). Histopathological verification was obtained in core biopsy or/and post-surgery specimens in all cases. Univariate logistic regression analysis was performed to assess the association between the subtypes and ultrasound imaging features. Experienced radiologists assessed lesions according to the BIRADS-US lexicon. The ultrasound scans were performed with a Supersonic Aixplorer and Supersonix. Based on histopathological verification, the rates of LA, LB HER2−, LB HER2+, HER2+, and TNBC were 33, 17, 17, 16, 19, respectively. Both LB HER2+ and HER2+ subtypes presented higher incidence of calcification (OR = 3.125, <i>p</i> = 0.02, CI 0.0917–5.87) and HER2+ subtype presented a higher incidence of posterior enhancement (OR = 5.75, <i>p</i> = 0.03, CI 1.2257–32.8005), compared to other subtypes. The calcifications were less common in TNBC (OR = 0.176, <i>p</i> = 0.0041, CI 0.0469–0.5335) compared to other subtypes. There were no differences with regard to margin, shape, orientation, elasticity values and vascularity among five molecular subtypes. Our results suggest that there is a correlation between ultrasonographic features assessed according to BIRADS-US lexicon and BC subtypes with HER2 overexpression (both LB HER2+ and HER2+). It may be useful for identification of these aggressive subtypes of breast cancer.
format	article
author	Magdalena Gumowska Joanna Mączewska Piotr Prostko Katarzyna Roszkowska-Purska Katarzyna Dobruch-Sobczak
author_facet	Magdalena Gumowska Joanna Mączewska Piotr Prostko Katarzyna Roszkowska-Purska Katarzyna Dobruch-Sobczak
author_sort	Magdalena Gumowska
title	Is There a Correlation between Multiparametric Assessment in Ultrasound and Intrinsic Subtype of Breast Cancer?
title_short	Is There a Correlation between Multiparametric Assessment in Ultrasound and Intrinsic Subtype of Breast Cancer?
title_full	Is There a Correlation between Multiparametric Assessment in Ultrasound and Intrinsic Subtype of Breast Cancer?
title_fullStr	Is There a Correlation between Multiparametric Assessment in Ultrasound and Intrinsic Subtype of Breast Cancer?
title_full_unstemmed	Is There a Correlation between Multiparametric Assessment in Ultrasound and Intrinsic Subtype of Breast Cancer?
title_sort	is there a correlation between multiparametric assessment in ultrasound and intrinsic subtype of breast cancer?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b7ef895f147a498fa0d28de7b6092002
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Is There a Correlation between Multiparametric Assessment in Ultrasound and Intrinsic Subtype of Breast Cancer?

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