The Toxicity Effect of Organophosphate (Diazinon) towards Duodenum Histopathology and The Activity of Superoxide Dismutase (SOD) Serum in Rats (Rattus Norvegicus)

Diazinon is an organophosphate insecticide that can inhibit acetyl-cholinesterase competitively and increase the production of Reactive Oxygen Species (ROS). ROS affect the activity of antioxidant enzymes such as superoxide Dismutase (SOD), and simultaneously ROS cause damage to the cells and duoden...

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Autores principales:	S. Efi Ulansari, Anna Roosdiana, Dyah Ayu Oktavianie A. P.
Formato:	article
Lenguaje:	EN
Publicado:	University of Brawijaya 2018
Materias:	diazinon organophosphate sod activity duodenum histopathology Chemistry QD1-999
Acceso en línea:	http://dx.doi.org/10.21776/ub.jpacr.2018.007.02.387 https://doaj.org/article/b7f37e0810f14d95a490a7d972578c06
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spelling	oai:doaj.org-article:b7f37e0810f14d95a490a7d972578c062021-12-02T14:13:22ZThe Toxicity Effect of Organophosphate (Diazinon) towards Duodenum Histopathology and The Activity of Superoxide Dismutase (SOD) Serum in Rats (Rattus Norvegicus)http://dx.doi.org/10.21776/ub.jpacr.2018.007.02.3872302-46902302-4690https://doaj.org/article/b7f37e0810f14d95a490a7d972578c062018-05-01T00:00:00Zhttps://jpacr.ub.ac.id/index.php/jpacr/article/view/387/pdfhttps://doaj.org/toc/2302-4690https://doaj.org/toc/2302-4690Diazinon is an organophosphate insecticide that can inhibit acetyl-cholinesterase competitively and increase the production of Reactive Oxygen Species (ROS). ROS affect the activity of antioxidant enzymes such as superoxide Dismutase (SOD), and simultaneously ROS cause damage to the cells and duodenum tissue. The toxicity effect of diazinon was investigated by measuring the activity of SOD serum and histopathology of the duodenum in rats (Rattus norvegicus). The activities of SOD serum were measured by using spectrophotometry, and histopathology changes of the duodenum were observed by using HE staining. Rats were divided into 4 groups, negative control group (K-), P1, P2, and P3 groups which were administrated with diazinon for 8 weeks orally with a dose of 20 mg/kgBW, 40 mg/kgBW, and 60 mg/kgBW respectively. The results showed that administration of diazinon orally decreased SOD activity significantly and caused damage of duodenal villi such as hyperplasia of epithelial cells, epithelial erosion, fatty degeneration, hyperplasia of Liberkuhn gland cells, and hemorrhage in the lamina propria.S. Efi UlansariAnna RoosdianaDyah Ayu Oktavianie A. P.University of Brawijayaarticlediazinonorganophosphatesod activityduodenum histopathologyChemistryQD1-999ENJournal of Pure and Applied Chemistry Research, Vol 7, Iss 2, Pp 109-115 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	diazinon organophosphate sod activity duodenum histopathology Chemistry QD1-999
spellingShingle	diazinon organophosphate sod activity duodenum histopathology Chemistry QD1-999 S. Efi Ulansari Anna Roosdiana Dyah Ayu Oktavianie A. P. The Toxicity Effect of Organophosphate (Diazinon) towards Duodenum Histopathology and The Activity of Superoxide Dismutase (SOD) Serum in Rats (Rattus Norvegicus)
description	Diazinon is an organophosphate insecticide that can inhibit acetyl-cholinesterase competitively and increase the production of Reactive Oxygen Species (ROS). ROS affect the activity of antioxidant enzymes such as superoxide Dismutase (SOD), and simultaneously ROS cause damage to the cells and duodenum tissue. The toxicity effect of diazinon was investigated by measuring the activity of SOD serum and histopathology of the duodenum in rats (Rattus norvegicus). The activities of SOD serum were measured by using spectrophotometry, and histopathology changes of the duodenum were observed by using HE staining. Rats were divided into 4 groups, negative control group (K-), P1, P2, and P3 groups which were administrated with diazinon for 8 weeks orally with a dose of 20 mg/kgBW, 40 mg/kgBW, and 60 mg/kgBW respectively. The results showed that administration of diazinon orally decreased SOD activity significantly and caused damage of duodenal villi such as hyperplasia of epithelial cells, epithelial erosion, fatty degeneration, hyperplasia of Liberkuhn gland cells, and hemorrhage in the lamina propria.
format	article
author	S. Efi Ulansari Anna Roosdiana Dyah Ayu Oktavianie A. P.
author_facet	S. Efi Ulansari Anna Roosdiana Dyah Ayu Oktavianie A. P.
author_sort	S. Efi Ulansari
title	The Toxicity Effect of Organophosphate (Diazinon) towards Duodenum Histopathology and The Activity of Superoxide Dismutase (SOD) Serum in Rats (Rattus Norvegicus)
title_short	The Toxicity Effect of Organophosphate (Diazinon) towards Duodenum Histopathology and The Activity of Superoxide Dismutase (SOD) Serum in Rats (Rattus Norvegicus)
title_full	The Toxicity Effect of Organophosphate (Diazinon) towards Duodenum Histopathology and The Activity of Superoxide Dismutase (SOD) Serum in Rats (Rattus Norvegicus)
title_fullStr	The Toxicity Effect of Organophosphate (Diazinon) towards Duodenum Histopathology and The Activity of Superoxide Dismutase (SOD) Serum in Rats (Rattus Norvegicus)
title_full_unstemmed	The Toxicity Effect of Organophosphate (Diazinon) towards Duodenum Histopathology and The Activity of Superoxide Dismutase (SOD) Serum in Rats (Rattus Norvegicus)
title_sort	toxicity effect of organophosphate (diazinon) towards duodenum histopathology and the activity of superoxide dismutase (sod) serum in rats (rattus norvegicus)
publisher	University of Brawijaya
publishDate	2018
url	http://dx.doi.org/10.21776/ub.jpacr.2018.007.02.387 https://doaj.org/article/b7f37e0810f14d95a490a7d972578c06
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The Toxicity Effect of Organophosphate (Diazinon) towards Duodenum Histopathology and The Activity of Superoxide Dismutase (SOD) Serum in Rats (Rattus Norvegicus)

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