Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

Accumulation of abnormal tau protein drives neurodegeneration in Alzheimer’s disease and related dementia disorders. Here, the authors demonstrate the endoplasmic reticulum unfolded protein response mediator XBP-1 controls pathological tau accumulation and the resultant neurodegeneration in a transg...

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Autores principales:	Sarah M. Waldherr, Timothy J. Strovas, Taylor A. Vadset, Nicole F. Liachko, Brian C. Kraemer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7f4bfc7537f47e98022e319db30674b
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spelling	oai:doaj.org-article:b7f4bfc7537f47e98022e319db30674b2021-12-02T14:40:17ZConstitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau10.1038/s41467-019-12070-32041-1723https://doaj.org/article/b7f4bfc7537f47e98022e319db30674b2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12070-3https://doaj.org/toc/2041-1723Accumulation of abnormal tau protein drives neurodegeneration in Alzheimer’s disease and related dementia disorders. Here, the authors demonstrate the endoplasmic reticulum unfolded protein response mediator XBP-1 controls pathological tau accumulation and the resultant neurodegeneration in a transgenic C. elegans model.Sarah M. WaldherrTimothy J. StrovasTaylor A. VadsetNicole F. LiachkoBrian C. KraemerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah M. Waldherr Timothy J. Strovas Taylor A. Vadset Nicole F. Liachko Brian C. Kraemer Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau
description	Accumulation of abnormal tau protein drives neurodegeneration in Alzheimer’s disease and related dementia disorders. Here, the authors demonstrate the endoplasmic reticulum unfolded protein response mediator XBP-1 controls pathological tau accumulation and the resultant neurodegeneration in a transgenic C. elegans model.
format	article
author	Sarah M. Waldherr Timothy J. Strovas Taylor A. Vadset Nicole F. Liachko Brian C. Kraemer
author_facet	Sarah M. Waldherr Timothy J. Strovas Taylor A. Vadset Nicole F. Liachko Brian C. Kraemer
author_sort	Sarah M. Waldherr
title	Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau
title_short	Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau
title_full	Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau
title_fullStr	Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau
title_full_unstemmed	Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau
title_sort	constitutive xbp-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b7f4bfc7537f47e98022e319db30674b
work_keys_str_mv	AT sarahmwaldherr constitutivexbp1smediatedactivationoftheendoplasmicreticulumunfoldedproteinresponseprotectsagainstpathologicaltau AT timothyjstrovas constitutivexbp1smediatedactivationoftheendoplasmicreticulumunfoldedproteinresponseprotectsagainstpathologicaltau AT tayloravadset constitutivexbp1smediatedactivationoftheendoplasmicreticulumunfoldedproteinresponseprotectsagainstpathologicaltau AT nicolefliachko constitutivexbp1smediatedactivationoftheendoplasmicreticulumunfoldedproteinresponseprotectsagainstpathologicaltau AT brianckraemer constitutivexbp1smediatedactivationoftheendoplasmicreticulumunfoldedproteinresponseprotectsagainstpathologicaltau
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Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

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