Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19

Abstract Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumon...

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Autores principales: Mattia Bellan, Alessio Baricich, Filippo Patrucco, Patrizia Zeppegno, Carla Gramaglia, Piero Emilio Balbo, Alessandro Carriero, Chiara Santa Amico, Gian Carlo Avanzi, Michela Barini, Marco Battaglia, Simone Bor, Vincenzo Cantaluppi, Giuseppe Cappellano, Federico Ceruti, Annalisa Chiocchetti, Elisa Clivati, Mara Giordano, Daria Cuneo, Eleonora Gambaro, Eleonora Gattoni, Alberto Loro, Marcello Manfredi, Umberto Morosini, Francesco Murano, Elena Paracchini, Giuseppe Patti, David James Pinato, Davide Raineri, Roberta Rolla, Pier Paolo Sainaghi, Stefano Tricca, Mario Pirisi
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b7f89da2e7f44cdf85752b2f708e7737
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spelling oai:doaj.org-article:b7f89da2e7f44cdf85752b2f708e77372021-11-28T12:18:07ZLong-term sequelae are highly prevalent one year after hospitalization for severe COVID-1910.1038/s41598-021-01215-42045-2322https://doaj.org/article/b7f89da2e7f44cdf85752b2f708e77372021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01215-4https://doaj.org/toc/2045-2322Abstract Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363–369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.Mattia BellanAlessio BaricichFilippo PatruccoPatrizia ZeppegnoCarla GramagliaPiero Emilio BalboAlessandro CarrieroChiara Santa AmicoGian Carlo AvanziMichela BariniMarco BattagliaSimone BorVincenzo CantaluppiGiuseppe CappellanoFederico CerutiAnnalisa ChiocchettiElisa ClivatiMara GiordanoDaria CuneoEleonora GambaroEleonora GattoniAlberto LoroMarcello ManfrediUmberto MorosiniFrancesco MuranoElena ParacchiniGiuseppe PattiDavid James PinatoDavide RaineriRoberta RollaPier Paolo SainaghiStefano TriccaMario PirisiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Mattia Bellan
Alessio Baricich
Filippo Patrucco
Patrizia Zeppegno
Carla Gramaglia
Piero Emilio Balbo
Alessandro Carriero
Chiara Santa Amico
Gian Carlo Avanzi
Michela Barini
Marco Battaglia
Simone Bor
Vincenzo Cantaluppi
Giuseppe Cappellano
Federico Ceruti
Annalisa Chiocchetti
Elisa Clivati
Mara Giordano
Daria Cuneo
Eleonora Gambaro
Eleonora Gattoni
Alberto Loro
Marcello Manfredi
Umberto Morosini
Francesco Murano
Elena Paracchini
Giuseppe Patti
David James Pinato
Davide Raineri
Roberta Rolla
Pier Paolo Sainaghi
Stefano Tricca
Mario Pirisi
Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19
description Abstract Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363–369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.
format article
author Mattia Bellan
Alessio Baricich
Filippo Patrucco
Patrizia Zeppegno
Carla Gramaglia
Piero Emilio Balbo
Alessandro Carriero
Chiara Santa Amico
Gian Carlo Avanzi
Michela Barini
Marco Battaglia
Simone Bor
Vincenzo Cantaluppi
Giuseppe Cappellano
Federico Ceruti
Annalisa Chiocchetti
Elisa Clivati
Mara Giordano
Daria Cuneo
Eleonora Gambaro
Eleonora Gattoni
Alberto Loro
Marcello Manfredi
Umberto Morosini
Francesco Murano
Elena Paracchini
Giuseppe Patti
David James Pinato
Davide Raineri
Roberta Rolla
Pier Paolo Sainaghi
Stefano Tricca
Mario Pirisi
author_facet Mattia Bellan
Alessio Baricich
Filippo Patrucco
Patrizia Zeppegno
Carla Gramaglia
Piero Emilio Balbo
Alessandro Carriero
Chiara Santa Amico
Gian Carlo Avanzi
Michela Barini
Marco Battaglia
Simone Bor
Vincenzo Cantaluppi
Giuseppe Cappellano
Federico Ceruti
Annalisa Chiocchetti
Elisa Clivati
Mara Giordano
Daria Cuneo
Eleonora Gambaro
Eleonora Gattoni
Alberto Loro
Marcello Manfredi
Umberto Morosini
Francesco Murano
Elena Paracchini
Giuseppe Patti
David James Pinato
Davide Raineri
Roberta Rolla
Pier Paolo Sainaghi
Stefano Tricca
Mario Pirisi
author_sort Mattia Bellan
title Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19
title_short Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19
title_full Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19
title_fullStr Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19
title_full_unstemmed Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19
title_sort long-term sequelae are highly prevalent one year after hospitalization for severe covid-19
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b7f89da2e7f44cdf85752b2f708e7737
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