An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

Islet amyloid polypeptide (IAPP) deposition is associated with islet cell loss in diabetes. Here the authors show that a small molecule autophagy enhancer reduces IAPP accumulation in vitro, and also improves glucose tolerance in hIAPP + mice fed high-fat diet, accompanied by reduced hIAPP accumulat...

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Autores principales: Jinyoung Kim, Kihyoun Park, Min Jung Kim, Hyejin Lim, Kook Hwan Kim, Sun-Woo Kim, Eun-Seo Lee, Hyongbum (Henry) Kim, Sung Joo Kim, Kyu Yeon Hur, Jae Hyeon Kim, Jin Hee Ahn, Kun-Ho Yoon, Ji-Won Kim, Myung-Shik Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b7f9dbe17f134b678299722702178b09
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Sumario:Islet amyloid polypeptide (IAPP) deposition is associated with islet cell loss in diabetes. Here the authors show that a small molecule autophagy enhancer reduces IAPP accumulation in vitro, and also improves glucose tolerance in hIAPP + mice fed high-fat diet, accompanied by reduced hIAPP accumulation, in vivo.

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