An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

Islet amyloid polypeptide (IAPP) deposition is associated with islet cell loss in diabetes. Here the authors show that a small molecule autophagy enhancer reduces IAPP accumulation in vitro, and also improves glucose tolerance in hIAPP + mice fed high-fat diet, accompanied by reduced hIAPP accumulat...

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Autores principales: Jinyoung Kim, Kihyoun Park, Min Jung Kim, Hyejin Lim, Kook Hwan Kim, Sun-Woo Kim, Eun-Seo Lee, Hyongbum (Henry) Kim, Sung Joo Kim, Kyu Yeon Hur, Jae Hyeon Kim, Jin Hee Ahn, Kun-Ho Yoon, Ji-Won Kim, Myung-Shik Lee
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b7f9dbe17f134b678299722702178b09
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spelling oai:doaj.org-article:b7f9dbe17f134b678299722702178b092021-12-02T15:16:22ZAn autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer10.1038/s41467-020-20454-z2041-1723https://doaj.org/article/b7f9dbe17f134b678299722702178b092021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20454-zhttps://doaj.org/toc/2041-1723Islet amyloid polypeptide (IAPP) deposition is associated with islet cell loss in diabetes. Here the authors show that a small molecule autophagy enhancer reduces IAPP accumulation in vitro, and also improves glucose tolerance in hIAPP + mice fed high-fat diet, accompanied by reduced hIAPP accumulation, in vivo.Jinyoung KimKihyoun ParkMin Jung KimHyejin LimKook Hwan KimSun-Woo KimEun-Seo LeeHyongbum (Henry) KimSung Joo KimKyu Yeon HurJae Hyeon KimJin Hee AhnKun-Ho YoonJi-Won KimMyung-Shik LeeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jinyoung Kim
Kihyoun Park
Min Jung Kim
Hyejin Lim
Kook Hwan Kim
Sun-Woo Kim
Eun-Seo Lee
Hyongbum (Henry) Kim
Sung Joo Kim
Kyu Yeon Hur
Jae Hyeon Kim
Jin Hee Ahn
Kun-Ho Yoon
Ji-Won Kim
Myung-Shik Lee
An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer
description Islet amyloid polypeptide (IAPP) deposition is associated with islet cell loss in diabetes. Here the authors show that a small molecule autophagy enhancer reduces IAPP accumulation in vitro, and also improves glucose tolerance in hIAPP + mice fed high-fat diet, accompanied by reduced hIAPP accumulation, in vivo.
format article
author Jinyoung Kim
Kihyoun Park
Min Jung Kim
Hyejin Lim
Kook Hwan Kim
Sun-Woo Kim
Eun-Seo Lee
Hyongbum (Henry) Kim
Sung Joo Kim
Kyu Yeon Hur
Jae Hyeon Kim
Jin Hee Ahn
Kun-Ho Yoon
Ji-Won Kim
Myung-Shik Lee
author_facet Jinyoung Kim
Kihyoun Park
Min Jung Kim
Hyejin Lim
Kook Hwan Kim
Sun-Woo Kim
Eun-Seo Lee
Hyongbum (Henry) Kim
Sung Joo Kim
Kyu Yeon Hur
Jae Hyeon Kim
Jin Hee Ahn
Kun-Ho Yoon
Ji-Won Kim
Myung-Shik Lee
author_sort Jinyoung Kim
title An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer
title_short An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer
title_full An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer
title_fullStr An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer
title_full_unstemmed An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer
title_sort autophagy enhancer ameliorates diabetes of human iapp-transgenic mice through clearance of amyloidogenic oligomer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b7f9dbe17f134b678299722702178b09
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