Excess cost of care associated with sepsis in cancer patients: Results from a population-based case-control matched cohort.

<h4>Background</h4>Cancer patients are at significant risk of developing sepsis due to underlying malignancy and necessary treatments. Little is known about the economic burden of sepsis in this high-risk population. We estimate the short- and long-term healthcare costs of care of cancer...

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Autores principales:	Michelle Tew, Kim Dalziel, Karin Thursky, Murray Krahn, Lusine Abrahamyan, Andrew M Morris, Philip Clarke
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7fb8df753b44a9fa02eddc9509f5a23
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spelling	oai:doaj.org-article:b7fb8df753b44a9fa02eddc9509f5a232021-12-02T20:15:03ZExcess cost of care associated with sepsis in cancer patients: Results from a population-based case-control matched cohort.1932-620310.1371/journal.pone.0255107https://doaj.org/article/b7fb8df753b44a9fa02eddc9509f5a232021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255107https://doaj.org/toc/1932-6203<h4>Background</h4>Cancer patients are at significant risk of developing sepsis due to underlying malignancy and necessary treatments. Little is known about the economic burden of sepsis in this high-risk population. We estimate the short- and long-term healthcare costs of care of cancer patients with and without sepsis using individual-level linked-administrative data.<h4>Methods</h4>We conducted a population-based matched cohort study of cancer patients aged ≥18, diagnosed between 2010 and 2017. Cases were identified if diagnosed with sepsis during the study period, and were matched 1:1 by age, sex, cancer type and other variables to controls without sepsis. Mean costs (2018 Canadian dollars) for patients with and without sepsis up to 5 years were estimated adjusted using survival probabilities at partitioned intervals. We estimated excess cost associated with sepsis presented as a cost difference between the two cohorts. Haematological and solid cancers were analysed separately.<h4>Results</h4>77,483 cancer patients with sepsis were identified and matched. 64.3% of the cohort were aged ≥65, 46.3% female and 17.8% with haematological malignancies. Among solid tumour patients, the excess cost of care among patients who developed sepsis was $29,081 (95%CI, $28,404-$29,757) in the first year, rising to $60,714 (95%CI, $59,729-$61,698) over 5 years. This was higher for haematology patients; $46,154 (95%CI, $45,505-$46,804) in year 1, increasing to $75,931 (95%CI, $74,895-$76,968).<h4>Conclusions</h4>Sepsis imposes substantial economic burden and can result in a doubling of cancer care costs, particularly during the first year of cancer diagnosis. These estimates are helpful in improving our understanding of burden of sepsis along the cancer pathway and to deploy targeted strategies to alleviate this burden.Michelle TewKim DalzielKarin ThurskyMurray KrahnLusine AbrahamyanAndrew M MorrisPhilip ClarkePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255107 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michelle Tew Kim Dalziel Karin Thursky Murray Krahn Lusine Abrahamyan Andrew M Morris Philip Clarke Excess cost of care associated with sepsis in cancer patients: Results from a population-based case-control matched cohort.
description	<h4>Background</h4>Cancer patients are at significant risk of developing sepsis due to underlying malignancy and necessary treatments. Little is known about the economic burden of sepsis in this high-risk population. We estimate the short- and long-term healthcare costs of care of cancer patients with and without sepsis using individual-level linked-administrative data.<h4>Methods</h4>We conducted a population-based matched cohort study of cancer patients aged ≥18, diagnosed between 2010 and 2017. Cases were identified if diagnosed with sepsis during the study period, and were matched 1:1 by age, sex, cancer type and other variables to controls without sepsis. Mean costs (2018 Canadian dollars) for patients with and without sepsis up to 5 years were estimated adjusted using survival probabilities at partitioned intervals. We estimated excess cost associated with sepsis presented as a cost difference between the two cohorts. Haematological and solid cancers were analysed separately.<h4>Results</h4>77,483 cancer patients with sepsis were identified and matched. 64.3% of the cohort were aged ≥65, 46.3% female and 17.8% with haematological malignancies. Among solid tumour patients, the excess cost of care among patients who developed sepsis was $29,081 (95%CI, $28,404-$29,757) in the first year, rising to $60,714 (95%CI, $59,729-$61,698) over 5 years. This was higher for haematology patients; $46,154 (95%CI, $45,505-$46,804) in year 1, increasing to $75,931 (95%CI, $74,895-$76,968).<h4>Conclusions</h4>Sepsis imposes substantial economic burden and can result in a doubling of cancer care costs, particularly during the first year of cancer diagnosis. These estimates are helpful in improving our understanding of burden of sepsis along the cancer pathway and to deploy targeted strategies to alleviate this burden.
format	article
author	Michelle Tew Kim Dalziel Karin Thursky Murray Krahn Lusine Abrahamyan Andrew M Morris Philip Clarke
author_facet	Michelle Tew Kim Dalziel Karin Thursky Murray Krahn Lusine Abrahamyan Andrew M Morris Philip Clarke
author_sort	Michelle Tew
title	Excess cost of care associated with sepsis in cancer patients: Results from a population-based case-control matched cohort.
title_short	Excess cost of care associated with sepsis in cancer patients: Results from a population-based case-control matched cohort.
title_full	Excess cost of care associated with sepsis in cancer patients: Results from a population-based case-control matched cohort.
title_fullStr	Excess cost of care associated with sepsis in cancer patients: Results from a population-based case-control matched cohort.
title_full_unstemmed	Excess cost of care associated with sepsis in cancer patients: Results from a population-based case-control matched cohort.
title_sort	excess cost of care associated with sepsis in cancer patients: results from a population-based case-control matched cohort.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b7fb8df753b44a9fa02eddc9509f5a23
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Excess cost of care associated with sepsis in cancer patients: Results from a population-based case-control matched cohort.

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