Gene expression and functional abnormalities in XX/Sry Leydig cells

Abstract The SRY gene induces testis development even in XX individuals. However, XX/Sry testes fail to produce mature sperm, due to the absence of Y chromosome carrying genes essential for spermatogenesis. XX/Sry Sertoli cells show abnormalities in the production of lactate and cholesterol required...

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Autores principales:	Shogo Yanai, Takashi Baba, Kai Inui, Kanako Miyabayashi, Soyun Han, Miki Inoue, Fumiya Takahashi, Yoshiakira Kanai, Yasuyuki Ohkawa, Man Ho Choi, Ken-ichirou Morohashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b7fc0ba3de484d65be555e4d60d3bc8e
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spelling	oai:doaj.org-article:b7fc0ba3de484d65be555e4d60d3bc8e2021-12-02T14:01:20ZGene expression and functional abnormalities in XX/Sry Leydig cells10.1038/s41598-020-80741-z2045-2322https://doaj.org/article/b7fc0ba3de484d65be555e4d60d3bc8e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80741-zhttps://doaj.org/toc/2045-2322Abstract The SRY gene induces testis development even in XX individuals. However, XX/Sry testes fail to produce mature sperm, due to the absence of Y chromosome carrying genes essential for spermatogenesis. XX/Sry Sertoli cells show abnormalities in the production of lactate and cholesterol required for germ cell development. Leydig cells are essential for male functions through testosterone production. However, whether XX/Sry adult Leydig cells (XX/Sry ALCs) function normally remains unclear. In this study, the transcriptomes from XY and XX/Sry ALCs demonstrated that immediate early and cholesterogenic gene expressions differed between these cells. Interestingly, cholesterogenic genes were upregulated in XX/Sry ALCs, although downregulated in XX/Sry Sertoli cells. Among the steroidogenic enzymes, CYP17A1 mediates steroid 17α-hydroxylation and 17,20-lyase reaction, necessary for testosterone production. In XX/Sry ALCs, the latter reaction was selectively decreased. The defects in XX/Sry ALCs, together with those in the germ and Sertoli cells, might explain the infertility of XX/Sry testes.Shogo YanaiTakashi BabaKai InuiKanako MiyabayashiSoyun HanMiki InoueFumiya TakahashiYoshiakira KanaiYasuyuki OhkawaMan Ho ChoiKen-ichirou MorohashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shogo Yanai Takashi Baba Kai Inui Kanako Miyabayashi Soyun Han Miki Inoue Fumiya Takahashi Yoshiakira Kanai Yasuyuki Ohkawa Man Ho Choi Ken-ichirou Morohashi Gene expression and functional abnormalities in XX/Sry Leydig cells
description	Abstract The SRY gene induces testis development even in XX individuals. However, XX/Sry testes fail to produce mature sperm, due to the absence of Y chromosome carrying genes essential for spermatogenesis. XX/Sry Sertoli cells show abnormalities in the production of lactate and cholesterol required for germ cell development. Leydig cells are essential for male functions through testosterone production. However, whether XX/Sry adult Leydig cells (XX/Sry ALCs) function normally remains unclear. In this study, the transcriptomes from XY and XX/Sry ALCs demonstrated that immediate early and cholesterogenic gene expressions differed between these cells. Interestingly, cholesterogenic genes were upregulated in XX/Sry ALCs, although downregulated in XX/Sry Sertoli cells. Among the steroidogenic enzymes, CYP17A1 mediates steroid 17α-hydroxylation and 17,20-lyase reaction, necessary for testosterone production. In XX/Sry ALCs, the latter reaction was selectively decreased. The defects in XX/Sry ALCs, together with those in the germ and Sertoli cells, might explain the infertility of XX/Sry testes.
format	article
author	Shogo Yanai Takashi Baba Kai Inui Kanako Miyabayashi Soyun Han Miki Inoue Fumiya Takahashi Yoshiakira Kanai Yasuyuki Ohkawa Man Ho Choi Ken-ichirou Morohashi
author_facet	Shogo Yanai Takashi Baba Kai Inui Kanako Miyabayashi Soyun Han Miki Inoue Fumiya Takahashi Yoshiakira Kanai Yasuyuki Ohkawa Man Ho Choi Ken-ichirou Morohashi
author_sort	Shogo Yanai
title	Gene expression and functional abnormalities in XX/Sry Leydig cells
title_short	Gene expression and functional abnormalities in XX/Sry Leydig cells
title_full	Gene expression and functional abnormalities in XX/Sry Leydig cells
title_fullStr	Gene expression and functional abnormalities in XX/Sry Leydig cells
title_full_unstemmed	Gene expression and functional abnormalities in XX/Sry Leydig cells
title_sort	gene expression and functional abnormalities in xx/sry leydig cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b7fc0ba3de484d65be555e4d60d3bc8e
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Gene expression and functional abnormalities in XX/Sry Leydig cells

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